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公开(公告)号：US08106197B2
公开(公告)日：2012-01-31
申请号：US11598765
申请日：2006-11-14
申请人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： C07D241/02
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译： 提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。 优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂。
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公开(公告)号：US07230098B2
公开(公告)日：2007-06-12
申请号：US10786610
申请日：2004-02-26
申请人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： C07D417/00 , C07D413/00 , C07D401/00 , C07D211/68 , C07D211/72
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET
摘要翻译： 提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。 优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂
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公开(公告)号：US20050009840A1
公开(公告)日：2005-01-13
申请号：US10786610
申请日：2004-02-26
申请人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： A61K20060101 , A61K31/44 , A61K31/496 , A61K31/4965 , A61K31/497 , C07D20060101 , C07D211/72 , C07D213/73 , C07D401/00 , C07D401/12 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D413/12 , C07D417/00 , C07D419/00 , C07
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译： 提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。 优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂。
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公开(公告)号：US20070072874A1
公开(公告)日：2007-03-29
申请号：US11598765
申请日：2006-11-14
申请人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： A61K31/4965 , A61K31/497 , A61K31/4439 , A61K31/4412 , C07D403/02
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译： 提供式（
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5.发明申请公开(公告)号：US20120263706A1
公开(公告)日：2012-10-18
申请号：US13537759
申请日：2012-06-29
申请人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/4418 , C07D403/10 , C07D401/10 , C07D213/73 , C07D401/14 , C07D401/04 , C07D403/04 , C07D521/00 , A61K31/4965 , A61K31/497 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61K39/395 , A61P35/00 , A61P35/02 , C07D241/20
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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6.发明授权Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 有权对映异构纯氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US07858643B2
公开(公告)日：2010-12-28
申请号：US11212331
申请日：2005-08-26
申请人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： C07D213/65 , C07D401/14 , A61K31/4412 , C07D401/04 , A61K31/496 , A61K31/4465
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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7.发明授权Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 有权对映异构纯氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US08785632B2
公开(公告)日：2014-07-22
申请号：US13537759
申请日：2012-06-29
申请人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： C07D401/10 , C07D401/04 , C07D401/14 , C07D213/73 , A61P35/00
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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8.发明申请公开(公告)号：US20100324061A1
公开(公告)日：2010-12-23
申请号：US12874073
申请日：2010-09-01
申请人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Jean Cui , Lee Andrew Funk , Lei Jia , Pei-Pei Kung , Jerry Jialun Meng , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/497 , C07D241/20 , C07D403/10 , C07D401/10 , C07D401/14 , C07D213/73 , C07D401/04 , C07D403/04 , A61K31/4965 , A61K31/4412 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61P35/00
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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9.发明申请Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 有权对映异构纯氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US20060046991A1
公开(公告)日：2006-03-02
申请号：US11212331
申请日：2005-08-26
申请人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/4965 , C07D213/72 , C07D241/20
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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公开(公告)号：US20060178374A1
公开(公告)日：2006-08-10
申请号：US11213038
申请日：2005-08-26
申请人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D213/76 , C07D241/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08
摘要： Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了氨基杂芳基化合物，以及它们的合成和使用方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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