公开(公告)号：US20120277882A1

公开(公告)日：2012-11-01

申请号：US13457610

申请日：2012-04-27

申请人： Jo-Wei HUANG ,  Po-Yang Chen ,  Ken-Yuan Chang

发明人： Jo-Wei HUANG ,  Po-Yang Chen ,  Ken-Yuan Chang

IPC分类号： A61F2/28 ,  C08L89/00 ,  C08L5/00 ,  C08L67/04

CPC分类号： A61L27/46 ,  A61L2430/02 ,  C08K7/18 ,  C08L2205/16 ,  C08L89/06 ,  C08L5/08 ,  C08L5/04 ,  C08L1/02

摘要： A biocompatible implant composite particle and the method of making the same are provided. The implant composite particle includes a bone filler particle and a plurality of fibers, in which each fiber is partially embedded in the bone filler particle, and has a free portion extending from a surface of the bone filler particle. Both bone filler particle and fibers are biocompatible. The biocompatible implant composite can be used in a bone filler material for bone defects.

摘要翻译： 提供生物相容性植入物复合颗粒及其制备方法。 植入物复合颗粒包括骨填料颗粒和多个纤维，其中每个纤维部分地嵌入骨填料颗粒中，并且具有从骨填料颗粒的表面延伸的自由部分。 骨填料颗粒和纤维都是生物相容的。 生物相容性植入物复合材料可用于骨缺损的骨填充材料。

公开(公告)号：US20110160322A1

公开(公告)日：2011-06-30

申请号：US12980053

申请日：2010-12-28

申请人： Jo-Wei HUANG ,  Po-Yang Chen

发明人： Jo-Wei HUANG ,  Po-Yang Chen

IPC分类号： C08K3/32 ,  C08L89/00 ,  C08L5/00

CPC分类号： A61L27/12 ,  A61L24/0036 ,  A61L24/02 ,  A61L27/025 ,  A61L27/56 ,  A61L2430/02

摘要： The present invention provides a porous bone cement containing a powder mixture and an aqueous solution, in which the aqueous solution is water or an inorganic salt solution and the powder mixture contains: (a) two or more bone substitution materials having different average particle sizes and independently selected from the group consisting of calcium phosphate salts, polymers and metals or salts thereof, provided that at least one of the bone substitution materials is calcium phosphate salts; (b) calcium sulfate; and (c) a bioresorbable molecule which is soluble in the aqueous solution and has higher biological resorption or degradation rate than calcium sulfate. The porous bone cement of the present invention is applicable in treating dental and bone defects and in plastic surgery. By mixing two or more bone substitution materials having different average particle sizes and two biomaterials having different biological resorption or degradation rates, the present invention provides a bone cement with suitable mechanical strength and porosity after hardened.

摘要翻译： 本发明提供一种含有粉末混合物和水溶液的多孔骨水泥，其中水溶液是水或无机盐溶液，粉末混合物含有：（a）两种或更多种具有不同平均粒度的骨取代材料， 独立地选自磷酸钙盐，聚合物和金属或其盐，条件是至少一种骨取代材料是磷酸钙盐; （b）硫酸钙; 和（c）可溶于水溶液并具有比硫酸钙更高的生物吸收或降解速率的生物可吸收分子。 本发明的多孔骨水泥适用于治疗牙齿和骨缺损以及整形手术。 通过混合具有不同平均粒度的两种或更多种骨取代材料和具有不同生物吸收或降解速率的两种生物材料，本发明提供一种在硬化后具有合适的机械强度和孔隙度的骨粘固剂。