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    CONTROLLED RELEASES OF ACTIVES IN SKIN
    2.
    发明申请
    CONTROLLED RELEASES OF ACTIVES IN SKIN 有权
    控制释放皮肤活动

    公开(公告)号：US20090317472A1

    公开(公告)日：2009-12-24

    申请号：US12525529

    申请日：2008-01-31

    申请人： Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    发明人： Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

    IPC分类号： A61K9/14 ,  A61P35/00 ,  A61P31/00

    CPC分类号： A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

    摘要： Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C —R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH═CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

    摘要翻译： 提供了局部组合物，其中通过角质层局部递送的活性化合物与具有A-B-A结构的三嵌段共聚物的纳米球络合，其中每个A端嵌段是水溶性的，亲水的和无毒的聚合物或低聚物; 并且疏水性中间B嵌段是具有相同或不同重复单元的疏水性聚合物或低聚物，其具有根据下式的结构：（I）其中X是-C-C-C或-C-; Z在2至约100之间（含）; R1为CH-CH或（CH2），其中n为0至18，包括端值; R2选自氢和含有至多18个碳原子的直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基; 并且R选自含有至多18个碳原子的键或直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基。

    Bioresorbable polymers synthesized from monomer analogs of natural metabolites
    4.
    发明授权
    Bioresorbable polymers synthesized from monomer analogs of natural metabolites 有权
    由天然代谢物的单体类似物合成的生物可吸收聚合物

    公开(公告)号：US08415449B2

    公开(公告)日：2013-04-09

    申请号：US13387798

    申请日：2010-07-31

    申请人： Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

    发明人： Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

    IPC分类号： C08G64/00 ,  C08G63/02

    CPC分类号： C08G79/02 ,  A61K47/59 ,  A61K47/60 ,  C08G79/025

    摘要： This invention discloses biocompatible polymers prepared from monomers (IV), and (IVa), or derivatives thereof, for which the variables are described in the claims and specification. These polymers may be bioresorbable and thus useful for manufacture of medical devices. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure.

    摘要翻译： 本发明公开了由权利要求和说明书中描述的变体描述的由单体（IV）和（IVa）或其衍生物制备的生物相容性聚合物。 这些聚合物可以是生物可再吸收的，因此可用于制造医疗器械。 因此，制备这些聚合物的方法和由其制备的医疗装置也包括在本公开中。

    Biphasic polymerization process
    9.
    发明授权
    Biphasic polymerization process 失效
    双相聚合工艺

    公开(公告)号：US06359102B1

    公开(公告)日：2002-03-19

    申请号：US09107753

    申请日：1998-06-29

    申请人： John E. Kemnitzer ,  George L. Brode ,  Joachim B. Kohn

    发明人： John E. Kemnitzer ,  George L. Brode ,  Joachim B. Kohn

    IPC分类号： C08G6424

    CPC分类号： C08G64/24 ,  C08G63/6856 ,  C08G63/79 ,  C08G63/87 ,  C08G64/12

    摘要： Improvements are disclosed for biphasic polymerization processes in which an aqueous solution of a first monomer that is hydrolytically unstable below a pH of about six or above a pH of about eight is admixed with a water-immiscible organic solvent and there is added to the admixture a catalyst selected from tertiary amine, quaternary amine and phosphonium catalysts, an acid-forming co-monomer for the first monomer, an acid scavenger, after which the resulting polymer is recovered, wherein the improvement includes providing the aqueous solution at a pH between about si and about eight, and adding to the admixture the acid-forming co-monomer and the acid scavenger at relative rates effective to maintain the pH of the admixture between about six and about eight. The catalyst may be added in a molar ratio to the first monomer effective to provide a predetermined weight-average or number-average molecular weight for the resulting polymer. Biphasic polymerization processes for monomers that are not pH sensitive are also disclosed.

    摘要翻译： 对于双相聚合方法公开了改进，其中将水解稳定性低于约6或大于约pH 8的水解不稳定的第一单体的水溶液与水不混溶的有机溶剂混合并加入到混合物a 选自叔胺，季胺和鏻催化剂的催化剂，用于第一单体的酸形成共聚单体，酸清除剂，之后回收所得聚合物，其中改进包括将水溶液提供在约si 和约8，并且以相对速率加入酸形成共聚单体和酸清除剂，以有效地将混合物的pH保持在约6至约8之间。 催化剂可以与第一单体的摩尔比加入，有效地为所得聚合物提供预定的重均分子量或数均分子量。 还公开了对不敏感的单体的双相聚合方法。