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公开(公告)号：US20070117807A1
公开(公告)日：2007-05-24
申请号：US11558132
申请日：2006-11-09
IPC分类号： A61K31/501 , A61K31/4965 , A61K31/497 , C07D403/02
CPC分类号： C07D207/335 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D213/40 , C07D213/64 , C07D215/12 , C07D231/12 , C07D231/16 , C07D233/56 , C07D233/64 , C07D235/14 , C07D249/08 , C07D277/28 , C07D307/14 , C07D307/52 , C07D405/12
摘要： The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).
摘要翻译： 本发明涉及制备式I的邻氨基苯甲酰胺的方法，其中R（1）至R（7）具有本文所指的含义，其制备方法，其作为药物的用途以及含有它们的药物制剂。 化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流器的钾电流。 因此，该化合物适合用作新的抗心律不齐剂，用于治疗和预防心律失常（例如心房颤动（AF）或心房扑动））。
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公开(公告)号：US07235690B2
公开(公告)日：2007-06-26
申请号：US10132163
申请日：2002-04-26
IPC分类号： C07C311/04 , A61K31/18
CPC分类号： C07D207/335 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D213/40 , C07D213/64 , C07D215/12 , C07D231/12 , C07D231/16 , C07D233/56 , C07D233/64 , C07D235/14 , C07D249/08 , C07D277/28 , C07D307/14 , C07D307/52 , C07D405/12
摘要： The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).
摘要翻译： 本发明涉及式I的邻氨基苯甲酰胺，其中R（1）至R（7）具有本文所述的含义，其制备方法，用作药物，以及含有它们的药物制剂。 化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流器的钾电流。 因此，该化合物适合用作新的抗心律不齐剂，用于治疗和预防心律失常（例如心房颤动（AF）或心房扑动））。
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公开(公告)号：US07332608B2
公开(公告)日：2008-02-19
申请号：US11558132
申请日：2006-11-09
IPC分类号： C07D213/02 , C07C311/04
CPC分类号： C07D207/335 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D213/40 , C07D213/64 , C07D215/12 , C07D231/12 , C07D231/16 , C07D233/56 , C07D233/64 , C07D235/14 , C07D249/08 , C07D277/28 , C07D307/14 , C07D307/52 , C07D405/12
摘要： The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).
摘要翻译： 本发明涉及制备式I的邻氨基苯甲酰胺的方法，其中R（1）至R（7）具有本文所指的含义，其制备方法，用作药物和含有它们的药物制剂。 化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流器的钾电流。 因此，该化合物适合用作新的抗心律不齐剂，用于治疗和预防心律失常（例如心房颤动（AF）或心房扑动））。
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4.发明授权Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效甲酰化呋喃和噻吩甲酰胺，它们的制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06982279B2
公开(公告)日：2006-01-03
申请号：US10012338
申请日：2001-12-12
IPC分类号： A61K31/38 , A61K31/34 , C07D333/38 , C07D307/02
CPC分类号： C07D333/38 , A61K31/34 , A61K31/38 , C07D307/68 , A61K2300/00
摘要： Compounds of the formulae IA and Ib. in which X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel antiarrhythmic active compounds, in particular for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters.
摘要翻译： 式IA和Ib的化合物。 其中X，R（1），R（2），R（3），R（4），R（5），R（6），R（7），R（30）和R 权利要求中指出的含义特别适合作为新的抗心律失常活性化合物，特别是用于治疗和预防心房心律失常，例如 心房颤动（AF）或心房扑动。
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5.发明授权Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them 失效邻位取代的含氮双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06794377B2
公开(公告)日：2004-09-21
申请号：US10002326
申请日：2001-12-05
IPC分类号： A61K3133
CPC分类号： C07D213/81 , C07D213/56 , C07D213/82 , C07D241/24 , C07D401/12 , C07D413/12
摘要： Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I
摘要翻译： 邻位取代的含氮双芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。 本发明的化合物包括式I的化合物
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6.发明授权Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效即，间位取代的双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06924392B2
公开(公告)日：2005-08-02
申请号：US10453646
申请日：2003-06-04
IPC分类号： A61K31/166 , A61K31/27 , A61K31/4418 , A61K31/444 , A61P9/06 , A61P43/00 , C07C233/66 , C07C235/34 , C07C237/42 , C07C271/22 , C07D213/79 , C07D213/81 , C07D213/82 , C07F5/02 , C07C233/05 , A61K31/16 , C07C233/65
CPC分类号： C07D213/79 , C07C235/34 , C07C271/22 , C07D213/81 , C07D213/82
摘要： Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I
摘要翻译： 正交的，间位取代的二芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如。 心房颤动（AF）或心房扑动。 本发明的化合物包括式I的化合物
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7.发明授权Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效即，间位取代的双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06605625B2
公开(公告)日：2003-08-12
申请号：US09995771
申请日：2001-11-29
IPC分类号： C07D21381
CPC分类号： C07D213/79 , C07C235/34 , C07C271/22 , C07D213/81 , C07D213/82
摘要： Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I in which: A1, A2, A3, A4, A5, A6, A7 and A8 independently of one another are chosen from nitrogen, CH and CR(5), at least four of these groups being CH, and wherein all other variables are as defined here.
摘要翻译： 正交的，间位取代的二芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如。 心房颤动（AF）或心房扑动。 本发明的化合物包括式Iin的化合物，其中：A1，A2，A3，A4，A5，A6，A7和A8彼此独立地选自氮，CH和CR（5），这些基团中的至少四个为 CH，并且其中所有其他变量如这里所定义。
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8.发明授权Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权具有杂芳基磺酰侧链的邻氨基苯甲酰胺，制备方法和用途公开(公告)号：US07235664B2
公开(公告)日：2007-06-26
申请号：US11052959
申请日：2005-02-08
IPC分类号： C07D215/36 , A61K31/47
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明包括具有杂芳基磺酰侧链的邻氨基苯甲酰胺，其制备方法，它们作为药物或诊断助剂的用途，以及含有它们的药物制剂。 其中R 1至R 7具有权利要求中所述含义的式I化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流剂的钾电流 。 因此，它们适合作为新的抗心律失常成分，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。
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公开(公告)号：US20050137200A1
公开(公告)日：2005-06-23
申请号：US11052959
申请日：2005-02-08
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K31/497 , A61K45/06 , A61P9/06 , C07D213/70 , C07D215/36 , C07D217/02 , C07D261/10 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K31/495 , A61K31/4965 , A61K31/50
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.
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10.发明授权Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权具有杂芳基磺酰侧链的邻氨基苯甲酰胺，制备方法和用途公开(公告)号：US06903216B2
公开(公告)日：2005-06-07
申请号：US10166595
申请日：2002-06-12
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K31/497 , A61K45/06 , A61P9/06 , C07D213/70 , C07D215/36 , C07D217/02 , C07D261/10 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明包括具有杂芳基磺酰侧链的邻氨基苯甲酰胺，其制备方法，它们作为药物或诊断助剂的用途，以及含有它们的药物制剂。 其中R 1至R 7具有权利要求中所述含义的式I化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流剂的钾电流 。 因此，它们适合作为新的抗心律失常成分，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。
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