公开(公告)号：US20050272963A1

公开(公告)日：2005-12-08

申请号：US10523925

申请日：2003-07-23

申请人： Jochem Henkelmann ,  Alois Kindler ,  Jan-Dirk Arndt ,  Katrin Klass

发明人： Jochem Henkelmann ,  Alois Kindler ,  Jan-Dirk Arndt ,  Katrin Klass

IPC分类号： C07B61/00 ,  C07C29/42 ,  C07C33/042 ,  C07C33/048 ,  C07C33/14 ,  C07C33/48 ,  C07C403/00 ,  C07C33/04 ,  C07F1/02

CPC分类号： C07C29/42 ,  C07C403/08 ,  C07C2601/16 ,  C07C33/042 ,  C07C33/048 ,  C07C33/14 ,  C07C33/48

摘要： The present invention relates to a process for preparing acetylene alcohols of the general formula I where R1 and R2 may be the same or different and are each independently hydrogen, a saturated or a mono- or polyunsaturated C1-C30-alkyl, aryl, cycloalkylalkyl or cycloalkyl radical, each of which may optionally be substituted, or a group of the general formula (II) where R3 and R4 may be the same or different and are each independently hydrogen or a saturated or a mono- or polyunsaturated C1-C30-alkyl, aryl, cycloalky alkyl or cycloalkyl radical, each of which may optionally be substituted, and the dashed line may represent an additional double bond, by monoethynylating a ketone of the general formula R1—CO—R2 by (a) reacting lithium with a C1-C10-alkyl halide (b) feeding in acetylene gas (c) adding the ketone.

摘要翻译： 本发明涉及一种制备通式I的乙炔醇的方法，其中R 1和R 2可以相同或不同，各自独立地为氢，饱和的 或单或多不饱和C 1 -C 30 - 烷基，芳基，环烷基烷基或环烷基，其各自可以任选被取代，或一个通式 （II）其中R 3和R 4可以相同或不同，各自独立地为氢或饱和或单不饱和或不饱和的C 1〜 其中每一个可以被任选地被取代，并且虚线可以代表另外的双键，通过使通式（I）的酮单乙炔基化， 通过（a）使锂与C 1 -C 10 - 烷基 - 取代的C 1 -C 10 - 烷基 卤化物（b）在乙炔气中进料（c）加入酮。

公开(公告)号：US06432861B1

公开(公告)日：2002-08-13

申请号：US09349082

申请日：1999-07-08

申请人： Boris Breitscheidel ,  Uwe Diehlmann ,  Alois Kindler ,  Jochem Henkelmann ,  Arnd Böttcher

发明人： Boris Breitscheidel ,  Uwe Diehlmann ,  Alois Kindler ,  Jochem Henkelmann ,  Arnd Böttcher

IPC分类号： C08F804

CPC分类号： C08F8/04 ,  B01J21/02

摘要： In a process for reacting an organic compound in the presence of a catalyst comprising, as active metal, at least one metal of transition group VIII of the Periodic Table, either alone or together with at least one metal of transition group I or VII of the Periodic Table, in an amount of from 0.01 to 30% by weight, based on the total weight of the catalyst, applied to a support containing macropores, the support comprises, as a support component, boron(III) oxide in an amount of from 10 to 100% by weight, based on the total weight of the support.

摘要翻译： 在一种催化剂存在下使有机化合物反应的方法，该催化剂包含作为活性金属的至少一种元素周期表第VIII族金属，单独或与至少一种第 周期表，以基于催化剂总重量的0.01至30重量％的量施用于含有大孔的载体，载体包含作为载体组分的氧化硼（III），其量为 10至100重量％，基于载体的总重量。

公开(公告)号：US06369282B1

公开(公告)日：2002-04-09

申请号：US09577127

申请日：2000-05-24

申请人： Alois Kindler ,  Thomas Preiss ,  Jochem Henkelmann

发明人： Alois Kindler ,  Thomas Preiss ,  Jochem Henkelmann

IPC分类号： C07C3118

CPC分类号： C07C29/42 ,  C07C33/044 ,  C07C33/046

摘要： The process for preparing alkynediols of the formula (I) R1R2C(OH)—C≡C—C(OH)R1R2  (I) where R1, R2 are each independently H, or a C1-20-hydrocarbon radical which may be substituted by one or more C1-6-alkyls and/or be interrupted by nonadjacent heteroatoms and/or contain C—C double or triple bonds, by reacting compounds of the formula (II) R1—C(═O)—R2  (II) with acetylene in a polar aprotic solvent is carried out in the presence of basic alkali metal salts as catalysts.

摘要翻译： 制备式（I）的炔二醇的方法，其中R 1，R 2各自独立地为H，或可被一个或多个C 1-6 - 烷基取代和/或被不相邻的杂原子中断的C 1-20烃基和/ 或含有CC双键或三键，通过使式（II）化合物与极性非质子溶剂中的乙炔反应，在碱性碱金属盐作为催化剂的存在下进行。

公开(公告)号：US06297407B1

公开(公告)日：2001-10-02

申请号：US09744437

申请日：2001-01-24

申请人： Alois Kindler ,  Melanie Brunner ,  Christian Tragut ,  Jochem Henkelmann

发明人： Alois Kindler ,  Melanie Brunner ,  Christian Tragut ,  Jochem Henkelmann

IPC分类号： C07C3118

CPC分类号： C07C29/42 ,  C07C33/042 ,  C07C33/044

摘要： The invention relates to a method for producing alkyne diols by reacting ketones with acetylenic hydrocarbons in an organic solvent in the presence of a base which contains potassium alcoholates of primary and/or secondary alcohols. The alkyne diols are produced while forming adducts which precipitate out of the reaction mixture and which are comprised of alkyne monoalcohols and/or alkyne diols and a base. The stoichiometries of the reaction partners are selected such that gelatinous adducts are formed which comprise a spherical surface, whereby the reaction mixture remains agitable during the entire reaction.

摘要翻译： 本发明涉及一种在含有伯醇和/或仲醇的醇钾的碱存在下，通过酮与炔烃在有机溶剂中反应制备炔烃的方法。 产生炔二醇，同时形成从反应混合物中沉淀的加合物，其由炔一醇和/或炔二醇和碱组成。 选择反应伴侣的化学计量，使得形成包含球形表面的凝胶状加合物，由此在整个反应期间反应混合物保持敏感。

公开(公告)号：US06956141B1

公开(公告)日：2005-10-18

申请号：US09913979

申请日：2000-02-22

申请人： Melanie Maas-Brunner ,  Jochem Henkelmann ,  Gerd Kaibel ,  Alois Kindler ,  Christian Knoll ,  Harald Rust ,  Christian Tragut ,  Manfred Stroezel ,  Udo Rheude ,  Rudolf Erich Lorenz ,  Juan Aiscar

发明人： Melanie Maas-Brunner ,  Jochem Henkelmann ,  Gerd Kaibel ,  Alois Kindler ,  Christian Knoll ,  Harald Rust ,  Christian Tragut ,  Manfred Stroezel ,  Udo Rheude ,  Rudolf Erich Lorenz ,  Juan Aiscar

IPC分类号： C07C29/17 ,  C07C29/42 ,  C07C33/042 ,  C07C33/04 ,  C07C33/044 ,  C07C33/046

CPC分类号： C07C29/42 ,  C07C29/172 ,  Y02P20/582 ,  C07C33/044 ,  C07C33/042 ,  C07C31/20

摘要： A process for preparing at least one unsaturated alcohol (B) comprises the steps (I) to (III) below: (I) reaction of at least one alkali metal hydroxide or alkaline earth metal hydroxide with at least one alcohol (A) in at least one organic solvent (L) to give a mixture (G-I) comprising at least the alcohol (A), the solvent (L) and an alkoxide (AL); (II) reaction of at least one carbonyl compound of the formula R—CO—R′ with at least one alkyne of the formula R″—C≡C—H and the mixture (G-I) obtained in step (I) to give a mixture (G-II) comprising at least the alcohol (A), the solvent (L) and an unsaturated alcohol (B); (III) distillation of the mixture (G-II) obtained in step (II) to give the alcohol or alcohols (B) and a mixture (G-III) comprising the solvent (L) and the alcohol (A), wherein the solvent (L) obtained in step (III) and the alcohol (A) obtained in step (III) are recycled as a mixture to step (I).

摘要翻译： 一种制备至少一种不饱和醇（B）的方法包括下列步骤（I）至（III）：（I）至少一种碱金属氢氧化物或碱土金属氢氧化物与至少一种醇（A）在 至少一种有机溶剂（L），得到至少包含醇（A），溶剂（L）和醇盐（AL）的混合物（GI） （II）至少一种式R-CO-R'的羰基化合物与至少一种式R'-C≡CH的炔和步骤（I）中获得的混合物（GI）的反应，得到混合物 至少包含醇（A），溶剂（L）和不饱和醇（B）的化合物（G-II）; （II）中获得的混合物（G-II）的蒸馏（III），得到醇或醇（B）和包含溶剂（L）和醇（A）的混合物（G-III），其中 将步骤（III）中获得的溶剂（L）和步骤（III）中获得的醇（A）作为步骤（I）的混合物再循环。

公开(公告)号：US06900332B2

公开(公告)日：2005-05-31

申请号：US10348961

申请日：2003-01-23

申请人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Michael Becker

发明人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Michael Becker

IPC分类号： C07D213/67 ,  C07D263/42 ,  C07D263/30

CPC分类号： B01D3/141 ,  C07D213/67 ,  C07D263/42

摘要： The present invention relates to a process for preparing 5-alkoxy-substituted oxazoles, in particular for preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

摘要翻译： 本发明涉及一种制备5-烷氧基取代的恶唑的方法，特别是制备4-甲基-5-烷氧基取代的恶唑，以及制备吡哆醇衍生物的方法。

公开(公告)号：US06828468B2

公开(公告)日：2004-12-07

申请号：US10138338

申请日：2002-05-06

申请人： Andreas Ansmann ,  Jochem Henkelmann ,  Alois Kindler ,  Heinz Etzrodt ,  Carsten Oost ,  Susanne Stutz ,  Christian Tragut ,  Bernhard Bockstiegel ,  Klaus Reimer ,  Manfred Stroezel ,  Walter Dobler

发明人： Andreas Ansmann ,  Jochem Henkelmann ,  Alois Kindler ,  Heinz Etzrodt ,  Carsten Oost ,  Susanne Stutz ,  Christian Tragut ,  Bernhard Bockstiegel ,  Klaus Reimer ,  Manfred Stroezel ,  Walter Dobler

IPC分类号： C07C3304

CPC分类号： C07C49/203 ,  B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0225 ,  C07C29/17 ,  C07C29/42 ,  C07C45/62 ,  C07C45/676 ,  C07C33/02 ,  C07C33/048 ,  C07C49/04

摘要： Higher &agr;,&bgr;-unsaturated alcohols are prepared by monoethynylation of a ketone by the NH3/KOH method, if desired hydrogenation of the acetylene alcohol in the presence of hydrogen over a Pd-containing thin layer catalyst, purifying distillation of the hydrogenation product, preferably in a dividing wall column with recirculation of the unreacted ketone to the ethynylation step, and, if desired, preparation of higher alcohols having in each case 5 more carbon atoms in the chain by reacting the alcohols prepared by monoethynylation and, if desired, partial hydrogenation with alkyl acetoacetates diketene in a Carroll reaction to form ketones and using these as starting materials for the steps ethynylation, optional hydrogenation and fractional distillation.

摘要翻译： 如果需要在氢气存在下在含Pd的薄层催化剂上氢化乙炔醇，纯化氢化产物的蒸馏，优选的是通过NH 3 / KOH方法将酮单异构化制备较高级的α，β-不饱和醇 在具有未反应酮再循环至乙炔化步骤的分隔壁塔中，并且如果需要，通过使通过单异丁烯基化制备的醇和如果需要的话进行部分氢化制备在各种情况下在链中多出5个碳原子的高级醇 在Carroll反应中使用烷基乙酰乙酸酯双烯酮形成酮，并将其用作步骤乙炔化，任选的氢化和分馏的起始原料。

公开(公告)号：US06713630B2

公开(公告)日：2004-03-30

申请号：US10300629

申请日：2002-11-21

申请人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

发明人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

IPC分类号： C07D26330

CPC分类号： B01D3/141 ,  C07D263/42

摘要： The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

公开(公告)号：US07038058B2

公开(公告)日：2006-05-02

申请号：US10726183

申请日：2003-12-03

申请人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

发明人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

IPC分类号： C07D263/30

CPC分类号： B01D3/141 ,  C07D263/42

摘要： The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

公开(公告)号：US20060157336A1

公开(公告)日：2006-07-20

申请号：US11384370

申请日：2006-03-21

申请人： Gerd Kaibel ,  Christian Miller ,  Katrin Klass ,  Alois Kindler ,  Werner Aquila ,  Walter Dobler ,  Klaus Breuer ,  Achim Pommer ,  Thomas Dirnsteiner

发明人： Gerd Kaibel ,  Christian Miller ,  Katrin Klass ,  Alois Kindler ,  Werner Aquila ,  Walter Dobler ,  Klaus Breuer ,  Achim Pommer ,  Thomas Dirnsteiner

IPC分类号： B01D3/00

CPC分类号： B01D3/141 ,  B01D3/14 ,  Y10S203/11 ,  Y10S203/20

摘要： A dividing-wall column having a dividing wall which is essentially disposed along the long direction of the column is proposed, which divides the column interior into a feed part, a take off part, an upper shared column part and a lower shared column part, with feed in whole or in part in the vaporous state of a mixture to be separated between the upper region of the feed part and the lower region of the feed part and/or side stream take off in whole or in part in the vaporous state between the upper region of the take off part and the lower region of the take off part, where if feed is in whole or in part in the vaporous state the cross-sectional area of the upper region of the feed part is increased by plane-parallel displacement of the dividing wall toward the upper region of the take off part, and/or if the side stream take off is in whole or in part in the vaporous state, the cross-sectional area of the lower region of the take off part is increased by displacement of the dividing wall toward the lower region of the feed part, in such a manner that the F factor is substantially the same in all column regions.