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公开(公告)号：US09409023B2
公开(公告)日：2016-08-09
申请号：US14007262
申请日：2012-03-26
申请人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangshen Chen
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangshen Chen
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Described are devices including stimulation assemblies connectable to a plurality of electrodes. The plurality of electrodes can be configured to connect to a spinal cord at a location below a lesion of the spinal cord. The stimulation assembly can be configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes when located below the lesion of the spinal cord. Methods of using the devices are also described.
摘要翻译： 描述了包括可连接到多个电极的刺激组件的装置。 多个电极可以被配置为在脊髓损伤下方的位置处连接到脊髓。 刺激组件可以被配置为当刺激组件连接到多个电极时位于脊髓的损伤下方时将刺激递送到多个电极中的选定的电极。 还描述了使用装置的方法。
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公开(公告)号：US20140180361A1
公开(公告)日：2014-06-26
申请号：US14007262
申请日：2012-03-26
申请人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Johnathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchruch , Douglas J. Jackson , Nicholas A. Terrafranca, JR.
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Johnathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchruch , Douglas J. Jackson , Nicholas A. Terrafranca, JR.
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.
摘要翻译： 一种用于与组（例如多于四组）电极组合的神经刺激器装置。 神经刺激器可以包括被配置为向每个组递送不同刺激的刺激组件。 神经刺激器还可以包括至少一个处理器，该处理器被配置为引导刺激组件将刺激传递给组。 输送到至少一个组的刺激可以包括除了正方形或矩形波形之外的一个或多个波形。 处理器可以从一个或多个传感器接收数据，并使用该数据来修改递送的刺激。 神经刺激器可以被配置为与外部计算设备进行通信。 神经刺激器可以向计算设备发送数据和/或从计算设备接收数据和/或指令。 计算设备可以使用由一个或多个传感器收集的信息来至少部分地确定刺激参数以与神经刺激器通信。
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3.发明申请公开(公告)号：US20140163640A1
公开(公告)日：2014-06-12
申请号：US13978035
申请日：2012-01-03
申请人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
发明人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
CPC分类号： A61N1/36103 , A61H1/0237 , A61H1/0274 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36003 , A61N1/36153 , A63B21/00181 , A63B22/0235 , A63B69/0064 , A63B2213/004 , A63B2220/805 , A63B2230/60 , F04C2270/0421
摘要： Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
摘要翻译： 在具有脊髓损伤，脑损伤或神经性神经运动疾病的人类受试者中实现运动控制，姿势控制，身体运动的自愿控制（例如，在非负重条件下）和/或自主神经功能的方法。 在某些实施方案中，所述方法包括使用硬膜外放置的电极阵列刺激受试者的脊髓，使受试者进行体育训练，从而产生本体感受和/或脊椎前信号，以及任选地向受试者施用药理学试剂。 刺激，身体训练和任选的药理学组合的组合在受试者的脊髓回路的实时电生理学特性中调节，以便它们被激发来自于有助于运动活动的受试者的区域的脊柱前信息和/或本体感受信息 。
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4.发明申请公开(公告)号：US20160030748A1
公开(公告)日：2016-02-04
申请号：US14790729
申请日：2015-07-02
申请人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
发明人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
CPC分类号： A61N1/36103 , A61H1/0237 , A61H1/0274 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36003 , A61N1/36153 , A63B21/00181 , A63B22/0235 , A63B69/0064 , A63B2213/004 , A63B2220/805 , A63B2230/60 , F04C2270/0421
摘要： Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.
摘要翻译： 描述了具有运动控制，姿势控制，身体运动的自愿控制（例如，在非负重条件下）和/或具有脊髓损伤，脑损伤或神经性神经运动疾病的人类受试者的自主功能的方法。
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5.发明授权High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury 有权高密度硬膜外刺激促进运动，姿势，自愿运动以及神经损伤后自主神经，性，血管舒缩和认知功能恢复公开(公告)号：US09101769B2
公开(公告)日：2015-08-11
申请号：US13978035
申请日：2012-01-03
申请人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
发明人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
CPC分类号： A61N1/36103 , A61H1/0237 , A61H1/0274 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36003 , A61N1/36153 , A63B21/00181 , A63B22/0235 , A63B69/0064 , A63B2213/004 , A63B2220/805 , A63B2230/60 , F04C2270/0421
摘要： Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
摘要翻译： 在具有脊髓损伤，脑损伤或神经性神经运动疾病的人类受试者中实现运动控制，姿势控制，身体运动的自愿控制（例如，在非负重条件下）和/或自主神经功能的方法。 在某些实施方案中，所述方法包括使用硬膜外放置的电极阵列刺激受试者的脊髓，对受试者进行身体训练，从而产生本体感受和/或脊椎前信号，以及任选地向受试者施用药理学试剂。 刺激，身体训练和任选的药理学组合的组合在受试者的脊髓回路的实时电生理学特性中调节，以便它们被激发来自于有助于运动活动的受试者的区域的脊柱前信息和/或本体感受信息 。
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