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公开(公告)号:US6130203A
公开(公告)日:2000-10-10
申请号:US243539
申请日:1999-02-03
申请人: Johannes J. Voorberg
发明人: Johannes J. Voorberg
IPC分类号: G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , A01N37/18 , A61K35/14
CPC分类号: C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要: Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
摘要翻译: 影响血液凝固的杂交蛋白质包括来自供体抗凝血剂或抗血栓形成蛋白质的区域,所得杂交蛋白质具有改良的生物活性。 关于杂交蛋白质的信息涉及编码具有这些DNA序列的蛋白质和宿主(包括转基因动物)的DNA序列; 针对杂交蛋白的抗体; 改变蛋白质性质的方法; 和使用杂合蛋白的治疗方法。
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公开(公告)号:US6051418A
公开(公告)日:2000-04-18
申请号:US243532
申请日:1999-02-03
申请人: Johannes J. Voorberg
发明人: Johannes J. Voorberg
IPC分类号: G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , C12N1/20 , A61K35/14 , C07H21/04 , C12P21/04
CPC分类号: C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要: Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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公开(公告)号:US5869292A
公开(公告)日:1999-02-09
申请号:US882083
申请日:1997-06-25
申请人: Johannes J. Voorberg
发明人: Johannes J. Voorberg
IPC分类号: G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , C12P21/04 , A61K35/14 , C12P21/06
CPC分类号: C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要: Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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公开(公告)号:US6156888A
公开(公告)日:2000-12-05
申请号:US324934
申请日:1999-06-03
申请人: Johannes J. Voorberg
发明人: Johannes J. Voorberg
IPC分类号: G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , C07H21/02 , A01N43/04 , C07H21/04
CPC分类号: C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要: Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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公开(公告)号:US5910481A
公开(公告)日:1999-06-08
申请号:US558107
申请日:1995-11-13
申请人: Johannes J. Voorberg
发明人: Johannes J. Voorberg
IPC分类号: G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , A61K35/14 , C12P21/04 , C12P21/06
CPC分类号: C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要: Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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