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公开(公告)号:US08840882B2
公开(公告)日:2014-09-23
申请号:US11823334
申请日:2007-06-25
摘要: The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
摘要翻译: 本发明一般涉及人核糖核酸酶和水溶性聚合物的缀合物,包含缀合物的组合物及其使用方法。 特别地,本发明提供人核糖核酸酶和一种或多种水溶性聚合物组合物的缀合物(例如,以增加血清半衰期和药代动力学特征,体内生物活性,稳定性和/或降低对 体内的蛋白质)以及在治疗,治疗和/或预防疾病(例如癌症)中使用缀合物的方法。
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公开(公告)号:US08298801B2
公开(公告)日:2012-10-30
申请号:US11879279
申请日:2007-07-17
申请人: John A. Kink , Laura E. Strong , Mark N. Shahan
发明人: John A. Kink , Laura E. Strong , Mark N. Shahan
CPC分类号: A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要: The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
摘要翻译: 本发明涉及向致病细胞,特别是癌细胞递送毒性试剂。 在一些实施方案中,毒性剂是对细胞有毒性的人核糖核酸酶或类似的试剂。
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公开(公告)号:US20130078229A1
公开(公告)日:2013-03-28
申请号:US13661937
申请日:2012-10-26
申请人: John A Kink , Laura E. Strong , Mark N. Shahan
发明人: John A Kink , Laura E. Strong , Mark N. Shahan
CPC分类号: A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要: The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
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公开(公告)号:US09192656B2
公开(公告)日:2015-11-24
申请号:US13661937
申请日:2012-10-26
申请人: John A Kink , Laura E. Strong , Mark N. Shahan
发明人: John A Kink , Laura E. Strong , Mark N. Shahan
CPC分类号: A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要: The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
摘要翻译: 本发明涉及向致病细胞,特别是癌细胞递送毒性试剂。 在一些实施方案中,毒性剂是对细胞有毒性的人核糖核酸酶或类似的试剂。
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