-
公开(公告)号：US08840882B2
公开(公告)日：2014-09-23
申请号：US11823334
申请日：2007-06-25
摘要： The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
摘要翻译： 本发明一般涉及人核糖核酸酶和水溶性聚合物的缀合物，包含缀合物的组合物及其使用方法。 特别地，本发明提供人核糖核酸酶和一种或多种水溶性聚合物组合物的缀合物（例如，以增加血清半衰期和药代动力学特征，体内生物活性，稳定性和/或降低对 体内的蛋白质）以及在治疗，治疗和/或预防疾病（例如癌症）中使用缀合物的方法。
-
公开(公告)号：US20130078229A1
公开(公告)日：2013-03-28
申请号：US13661937
申请日：2012-10-26
申请人： John A Kink , Laura E. Strong , Mark N. Shahan
发明人： John A Kink , Laura E. Strong , Mark N. Shahan
CPC分类号： A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要： The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
-
公开(公告)号：US06538072B2
公开(公告)日：2003-03-25
申请号：US09888098
申请日：2001-06-22
IPC分类号： C08F830
CPC分类号： B01J31/2404 , B01J19/0046 , B01J31/2265 , B01J2219/00497 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00637 , B01J2219/00722 , B01J2219/00738 , B01J2231/14 , B01J2531/821 , C07B2200/11 , C07F15/002 , C07F15/0046 , C08F10/00 , C40B40/14 , C08F2/38 , C08F4/80
摘要： A method of preparing a multivalent array that includes: polymerizing at least one monomer comprising at least one polymerizable group and at least one latent reactive group in the presence of a metal carbene catalyst to form a polymer template comprising at least one latent reactive group; and combining the polymer template with at least one functionalizing reagent comprising at least one reactive group under conditions effective to react the latent reactive group of the polymer template with the reactive group of the functionalizing reagent to form a multivalent array.
-
公开(公告)号：US06271315B1
公开(公告)日：2001-08-07
申请号：US09335430
申请日：1999-06-17
IPC分类号： C08F830
CPC分类号： B01J31/2404 , B01J19/0046 , B01J31/2265 , B01J2219/00497 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00637 , B01J2219/00722 , B01J2219/00738 , B01J2231/14 , B01J2531/821 , C07B2200/11 , C07F15/002 , C07F15/0046 , C08F10/00 , C40B40/14 , C08F2/38 , C08F4/80
摘要： A method of preparing a multivalent array that includes: polymerizing at least one monomer comprising at least one polymerizable group and at least one latent reactive group in the presence of a metal carbene catalyst to form a polymer template comprising at least one latent reactive group; and combining the polymer template with at least one functionalizing reagent comprising at least one reactive group under conditions effective to react the latent reactive group of the polymer template with the reactive group of the functionalizing reagent to form a multivalent array.
摘要翻译： 一种制备多价阵列的方法，其包括：在金属卡宾催化剂的存在下聚合至少一种包含至少一个可聚合基团和至少一个潜在反应性基团的单体以形成包含至少一个潜在反应性基团的聚合物模板; 以及在有效使聚合物模板的潜在反应性基团与官能化试剂的反应性基团反应形成多价阵列的条件下，将聚合物模板与至少一种包含至少一个反应性基团的官能化试剂组合。
-
公开(公告)号：US08697062B2
公开(公告)日：2014-04-15
申请号：US12247438
申请日：2008-10-08
CPC分类号： C12N9/22 , A61K38/00 , C12Y301/27005
摘要： The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
摘要翻译： 本发明一般涉及人核糖核酸酶和水溶性聚合物的缀合物，包含缀合物的组合物及其使用方法。 特别地，本发明提供人核糖核酸酶和一种或多种水溶性聚合物组合物的缀合物（例如，以增加血清半衰期和药代动力学特征，体内生物活性，稳定性和/或降低对 体内的蛋白质）以及在治疗，治疗和/或预防疾病（例如癌症）中使用缀合物的方法。
-
公开(公告)号：US08470315B2
公开(公告)日：2013-06-25
申请号：US11105041
申请日：2005-04-13
申请人： Laura E. Strong , Peter A. Leland , Thomas Burke
发明人： Laura E. Strong , Peter A. Leland , Thomas Burke
CPC分类号： A61K38/465 , A61K47/6815 , A61K47/6851 , A61K47/6867 , C07K16/18 , C07K16/2803 , C07K16/3061 , C12N9/12 , C12N9/22 , C12N9/96 , C12Y301/27005
摘要： The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.
摘要翻译： 本发明涉及将毒性蛋白质递送至致病细胞，特别是癌细胞。 在优选的实施方案中，毒性蛋白质是已经被修饰以使其对靶细胞有毒并且可以与靶细胞特异性递送载体（例如抗体）缀合用于递送至致病细胞的核糖核酸酶。
-
公开(公告)号：US20090098101A1
公开(公告)日：2009-04-16
申请号：US12247438
申请日：2008-10-08
CPC分类号： C12N9/22 , A61K38/00 , C12Y301/27005
摘要： The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
摘要翻译： 本发明一般涉及人核糖核酸酶和水溶性聚合物的缀合物，包含缀合物的组合物及其使用方法。 特别地，本发明提供人核糖核酸酶和一种或多种水溶性聚合物组合物的缀合物（例如，以增加血清半衰期和药代动力学特征，体内生物活性，稳定性和/或降低对 体内的蛋白质）以及在治疗，治疗和/或预防疾病（例如癌症）中使用缀合物的方法。
-
公开(公告)号：US09192656B2
公开(公告)日：2015-11-24
申请号：US13661937
申请日：2012-10-26
申请人： John A Kink , Laura E. Strong , Mark N. Shahan
发明人： John A Kink , Laura E. Strong , Mark N. Shahan
CPC分类号： A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要： The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
摘要翻译： 本发明涉及向致病细胞，特别是癌细胞递送毒性试剂。 在一些实施方案中，毒性剂是对细胞有毒性的人核糖核酸酶或类似的试剂。
-
公开(公告)号：US08298801B2
公开(公告)日：2012-10-30
申请号：US11879279
申请日：2007-07-17
申请人： John A. Kink , Laura E. Strong , Mark N. Shahan
发明人： John A. Kink , Laura E. Strong , Mark N. Shahan
CPC分类号： A61K38/465 , A61K38/00 , A61K45/06 , A61K47/10 , A61N5/10 , C12N9/22 , C12Y301/27005
摘要： The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
摘要翻译： 本发明涉及向致病细胞，特别是癌细胞递送毒性试剂。 在一些实施方案中，毒性剂是对细胞有毒性的人核糖核酸酶或类似的试剂。
-
10.发明授权Methods and reagents for capping ruthenium or osmium carbene-catalyzed ROMP products 有权用于封盖钌或锇卡因催化的ROMP产品的方法和试剂公开(公告)号：US06291616B1
公开(公告)日：2001-09-18
申请号：US09336121
申请日：1999-06-17
IPC分类号： C08F426
CPC分类号： C08F10/00 , B01J19/0046 , B01J31/1805 , B01J31/2208 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2219/00497 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00637 , B01J2219/00722 , B01J2219/00738 , B01J2231/14 , B01J2531/821 , B01J2531/825 , C07B2200/11 , C07F15/002 , C07F15/0046 , C40B40/14 , C08F4/80 , C08F2/38
摘要： Methods of preparing a telechelic polymer (mono- or bi-telechelic) that use a ruthenium or osmium carbene catalyst and a capping agent, at least one of which is functionalized.
摘要翻译： 制备使用钌或锇卡因催化剂和封端剂的遥爪聚合物（单 - 或双遥爪）的方法，其中至少一种被官能化。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.022 秒)