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公开(公告)号：US08840882B2
公开(公告)日：2014-09-23
申请号：US11823334
申请日：2007-06-25
摘要： The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
摘要翻译： 本发明一般涉及人核糖核酸酶和水溶性聚合物的缀合物，包含缀合物的组合物及其使用方法。 特别地，本发明提供人核糖核酸酶和一种或多种水溶性聚合物组合物的缀合物（例如，以增加血清半衰期和药代动力学特征，体内生物活性，稳定性和/或降低对 体内的蛋白质）以及在治疗，治疗和/或预防疾病（例如癌症）中使用缀合物的方法。
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2.发明授权Compositions and processes using siRNA, amphipathic compounds and polycations 有权使用siRNA，两亲性化合物和聚阳离子的组合物和方法公开(公告)号：US07601367B2
公开(公告)日：2009-10-13
申请号：US10845968
申请日：2004-05-14
申请人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
发明人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
CPC分类号： C12N15/111 , A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/0025 , A61K48/0041 , C07H21/04 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
摘要翻译： 描述了具有低毒性的可递送组合物，其包含两亲性化合物，聚阳离子和siRNA。 组合物可以用于将siRNA递送到动物细胞或更特别是哺乳动物细胞的过程中。
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公开(公告)号：US20090124777A1
公开(公告)日：2009-05-14
申请号：US12352828
申请日：2009-01-13
IPC分类号： C08F126/00 , C08G73/06
CPC分类号： A61K48/0041 , C12N15/87
摘要： Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo.
摘要翻译： 描述了含有环脒的化合物及其制备方法。 含有这些化合物的组合物有助于将体内和体内的生物活性聚合物递送至细胞。
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4.发明授权公开(公告)号：US07482160B2
公开(公告)日：2009-01-27
申请号：US11322419
申请日：2005-12-30
申请人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
发明人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
IPC分类号： C12N15/88
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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公开(公告)号：US20060039860A1
公开(公告)日：2006-02-23
申请号：US11154494
申请日：2005-06-16
申请人： Sean Monahan , Vladimir Trubetskoy
发明人： Sean Monahan , Vladimir Trubetskoy
CPC分类号： A61K48/0041 , C12N15/87
摘要： Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo.
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公开(公告)号：US20070219363A1
公开(公告)日：2007-09-20
申请号：US11738146
申请日：2007-04-20
申请人： Vladimir Budker , Jon Wolff , Sean Monahan , Paul Slattum , James Hagstrom , Vladimir Trubetskoy , Tatyana Budker
发明人： Vladimir Budker , Jon Wolff , Sean Monahan , Paul Slattum , James Hagstrom , Vladimir Trubetskoy , Tatyana Budker
IPC分类号： C07D323/00 , C07C211/00 , C07H21/00
CPC分类号： C07D207/16
摘要： Chelator containing compounds are utilized in the delivery of molecules and polymers to animal cells. At least one chelator such as crown ether is attached to a polymer and then associated with another polymer. An ion is then added to the mixture thereby forming condensed polymer. In condensed form and in complex with the chelator, polymer can be delivered to a cell.
摘要翻译： 含螯合剂的化合物用于向动物细胞递送分子和聚合物。 至少一种螯合剂如冠醚连接到聚合物上，然后与另一种聚合物缔合。 然后将离子加入到混合物中，从而形成冷凝聚合物。 在浓缩形式和与螯合剂复合的情况下，聚合物可被递送至电池。
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公开(公告)号：US20070036865A1
公开(公告)日：2007-02-15
申请号：US11533115
申请日：2006-09-19
申请人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
发明人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
摘要： We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
摘要翻译： 我们描述了pH敏感的内分泌溶解聚合物，包含pH敏感的内分解溶解聚合物的递送颗粒。 所述的颗粒能够将多核苷酸递送至来自外周循环的细胞，随后从内体释放。 内细胞分解的聚合物在细胞外是无活性的，但在暴露于酸化的内体室时破坏膜。
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公开(公告)号：US20070021364A1
公开(公告)日：2007-01-25
申请号：US11437933
申请日：2006-05-19
申请人： Hans Herweijer , Jon Wolff , Mary Bates , Aaron Loomis , Vladimir Trubetskoy
发明人： Hans Herweijer , Jon Wolff , Mary Bates , Aaron Loomis , Vladimir Trubetskoy
CPC分类号： A61K39/0005 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/6093 , C07K16/00 , C12N2730/10134
摘要： The present invention relates to methods for delivering a genetic immunogen, comprising a nucleic acid capable of expressing an antigen, optionally complexed with a polymer. The nucleic acid is delivered to the host via hydrodynamic intravascular injection resulting in expression of an encoded antigen in extravascular cells and induction of an antigen-specific immune response.
摘要翻译： 本发明涉及递送遗传免疫原的方法，其包含能够表达抗原的核酸，任选与聚合物配合。 通过流体动力学血管内注射将核酸递送至宿主，导致编码的抗原在血管外细胞中的表达和诱导抗原特异性免疫应答。
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公开(公告)号：US07045356B2
公开(公告)日：2006-05-16
申请号：US10795679
申请日：2004-03-08
申请人： Vladimir Trubetskoy , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , So Chun Wong , Jason Klein
发明人： Vladimir Trubetskoy , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , So Chun Wong , Jason Klein
IPC分类号： C12N15/88
CPC分类号： A61K48/0008
摘要： We describe a process for generating multilayer particles comprising condensing a polymer with an oppositely charged polymer to form a particle and sequentially adding oppositely charged polymers to the particle forming at least three layers of polymers. The process is used to form a composition for delivering a biologically active compound to a cell.
摘要翻译： 我们描述了一种产生多层颗粒的方法，包括将聚合物与带相反电荷的聚合物缩合形成颗粒，并依次向形成至少三层聚合物的颗粒中加入带相反电荷的聚合物。 该方法用于形成用于将生物活性化合物递送至细胞的组合物。
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公开(公告)号：US07022525B2
公开(公告)日：2006-04-04
申请号：US10755785
申请日：2004-01-12
申请人： Vladimir Trubetskoy , Jon A. Wolff , Paul M. Slattum , Lisa Hanson , Vladimir G. Budker , James E. Hagstrom
发明人： Vladimir Trubetskoy , Jon A. Wolff , Paul M. Slattum , Lisa Hanson , Vladimir G. Budker , James E. Hagstrom
IPC分类号： C12N15/09 , C12N15/00 , C12N15/11 , A61K48/00 , A61K39/395
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
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