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    Methods for non-invasive analyte measurement from the conjunctiva
    1.
    发明申请
    Methods for non-invasive analyte measurement from the conjunctiva 失效
    从结膜进行非侵入性分析物测量的方法

    公开(公告)号：US20050085701A1

    公开(公告)日：2005-04-21

    申请号：US10824214

    申请日：2004-04-14

    申请人： John Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

    发明人： John Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

    摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

    摘要翻译： 本发明涉及通过测量来自受试者结膜的电磁辐射特征来检测受试者组织中分析物浓度水平的非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面，仪器用中红外范围内的电磁辐射泛滥受试者的结膜，并根据反射回仪器的中红外辐射测量分析物浓度。

    Methods and device for non-invasive analyte measurement
    3.
    发明授权
    Methods and device for non-invasive analyte measurement 失效
    用于非侵入性分析物测量的方法和装置

    公开(公告)号：US06968222B2

    公开(公告)日：2005-11-22

    申请号：US10428410

    申请日：2003-05-02

    申请人： John F. Burd ,  Jacob Fraden ,  Charles E. Kramer ,  Gary Krantz ,  William Sell

    发明人： John F. Burd ,  Jacob Fraden ,  Charles E. Kramer ,  Gary Krantz ,  William Sell

    IPC分类号： A61B3/117 ,  A61B5/00

    CPC分类号： A61B5/14532 ,  A61B3/10 ,  A61B5/14546 ,  A61B5/1455

    摘要： The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

    摘要翻译： 本发明涉及用于检测受试者组织中分析物浓度水平的光学非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面中，仪器用对象眼睛的中心红外范围的辐射使物体的身体表面泛滥，并且基于反射回仪器的中红外辐射来测量分析物浓度。

    Method and instruments for non-invasive analyte measurement
    4.
    发明授权
    Method and instruments for non-invasive analyte measurement 失效
    用于非侵入性分析物测量的方法和仪器

    公开(公告)号：US06958039B2

    公开(公告)日：2005-10-25

    申请号：US10824254

    申请日：2004-04-14

    申请人： John F. Burd ,  Gary Krantz ,  William Sell

    发明人： John F. Burd ,  Gary Krantz ,  William Sell

    IPC分类号： A61B3/117 ,  A61B5/00

    CPC分类号： A61B5/1455 ,  A61B3/10 ,  A61B3/117 ,  A61B5/14532 ,  A61B5/14546

    摘要： The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument measures the level of mid-infrared radiation from the subject's body surface, such as the eye, and determines a specific analyte's concentration based on said analyte's distinctive mid-infrared radiation signature.

    摘要翻译： 本发明涉及用于检测受试者组织中分析物浓度水平的光学非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面中，仪器测量来自对象的身体表面（例如眼睛）的中红外辐射的水平，并且基于所述分析物的特征性中红外辐射特征确定特定分析物的浓度。

    Test strip including integral specimen flow retarding structure
    5.
    发明授权
    Test strip including integral specimen flow retarding structure 失效
    测试条包括整体样品流延结构

    公开(公告)号：US5755231A

    公开(公告)日：1998-05-26

    申请号：US442672

    申请日：1995-05-17

    申请人： Gary Krantz ,  Shuenn-Tzong Chen ,  Adam Zipp ,  Joanne Zeng

    发明人： Gary Krantz ,  Shuenn-Tzong Chen ,  Adam Zipp ,  Joanne Zeng

    IPC分类号： G01N33/52 ,  A61B5/00

    CPC分类号： G01N33/525

    摘要： A test strip includes a first layer and an overlying differential flow-retarding layer that reduces the fraction of a component of a liquid specimen percolated therethrough. An inert backing, preferably having an aperture therethrough, overlies the flow-retarding layer. For the testing of a blood specimen, the flow-retarding layer is formed of glass fibers that reduce the fraction of red blood cells in the percolate, leaving primarily, but not entirely, plasma in the percolate. The first layer includes chemicals that react with a component of the plasma such as glucose in a measurable reaction, preferably a visually measurable reaction. In using this test strip, the blood specimen is placed into the aperture of the backing and permitted to percolate through the flow-retarding layer such that a fraction of the red blood cells is removed from the percolate. The chemicals in the first layer react with the glucose in the plasma to produce a change that is visually measurable from the bottom side of the active layer with reduced visual interference from the red color of whole blood on the bottom side of the reaction layer.

    摘要翻译： 测试条包括第一层和上覆的差分阻流层，其减少通过其渗透的液体样品的组分的分数。 优选具有穿过其中的孔的惰性背衬覆盖在阻流层上。 为了测试血液样本，阻滞层由玻璃纤维形成，玻璃纤维减少了渗滤液中红细胞的分数，主要而不是完全留在渗滤液中的血浆。 第一层包括在可测量的反应中，优选视觉上可测量的反应与等离子体组分如葡萄糖反应的化学物质。 在使用该测试条时，将血液样本放入背衬的孔中并允许渗透通过阻滞层，使得从渗滤液中除去一部分红细胞。 第一层中的化学物质与等离子体中的葡萄糖反应，产生从活性层底部可视化测量的变化，减少了反应层底部全血红色的视觉干扰。