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公开(公告)号：US20100092542A1
公开(公告)日：2010-04-15
申请号：US12508367
申请日：2009-07-23
申请人： John Burnier , Thomas Gadek , Wang Shen , Johan D. Oslob , Kenneth Barr
发明人： John Burnier , Thomas Gadek , Wang Shen , Johan D. Oslob , Kenneth Barr
IPC分类号： A61K9/00 , A61K9/127 , A61K9/12 , A61K31/4725 , C07D401/14 , A61P27/02
CPC分类号： A61K31/4725 , A61B3/101 , A61B3/145 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0053 , A61K31/197 , A61K31/198 , A61K31/275 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4162 , A61K31/4184 , A61K31/4192 , A61K31/44 , A61K31/4709 , A61K31/472 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K33/00 , A61K33/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K38/1703 , A61K45/06 , C07C279/28 , C07C317/50 , C07D207/06 , C07D217/00 , C07D217/02 , C07D217/06 , C07D217/20 , C07D217/26 , C07D307/52 , C07D333/38 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , G01N33/5011 , G01N33/5032 , G01N33/5047 , G01N33/566 , G01N33/6872 , G01N2333/705 , G01N2333/70525 , G01N2333/70546 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/16 , Y10S514/912 , Y10S514/914
摘要： The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
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公开(公告)号：US20120232019A1
公开(公告)日：2012-09-13
申请号：US13398542
申请日：2012-02-16
申请人： Thomas Gadek , John Burnier , Johan Oslob , Wang Shen , Kenneth Barr , Min Zhong
发明人： Thomas Gadek , John Burnier , Johan Oslob , Wang Shen , Kenneth Barr , Min Zhong
IPC分类号： A61K31/473 , A61K31/437 , A61K31/197 , A61K31/343 , C07D409/14 , A61K31/341 , C07D405/14 , C07D471/04 , C07D409/12 , A61K38/02 , A61K31/4015
CPC分类号： A61K31/4725 , A61B3/101 , A61B3/145 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0053 , A61K31/197 , A61K31/198 , A61K31/275 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4162 , A61K31/4184 , A61K31/4192 , A61K31/44 , A61K31/4709 , A61K31/472 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K33/00 , A61K33/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K38/1703 , A61K45/06 , C07C279/28 , C07C317/50 , C07D207/06 , C07D217/00 , C07D217/02 , C07D217/06 , C07D217/20 , C07D217/26 , C07D307/52 , C07D333/38 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , G01N33/5011 , G01N33/5032 , G01N33/5047 , G01N33/566 , G01N33/6872 , G01N2333/705 , G01N2333/70525 , G01N2333/70546 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/16 , Y10S514/912 , Y10S514/914
摘要： The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
摘要翻译： 本发明提供了用于治疗LFA-1介导的疾病的化合物和方法。 特别地，本文描述了LFA-1拮抗剂，并且这些拮抗剂用于治疗LFA-1介导的疾病。 在患者被诊断患有LFA-1介导的疾病之后，本发明的一个方面提供LFA-1介导的疾病的诊断和LFA-1拮抗剂的施用。 在一些实施方案中，治疗的LFA-1介导的疾病是干眼症。 本文还提供了用于鉴定LFA-1拮抗剂的化合物的方法。
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公开(公告)号：US07989626B2
公开(公告)日：2011-08-02
申请号：US13021013
申请日：2011-02-04
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： C07D217/04
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供了具有式（I）的化合物及其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和类别和亚类所述，另外 提供其药物组合物及其用于治疗CD11 / CD18家族细胞粘附分子（例如LFA-1）介导的病症的方法。
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公开(公告)号：US07928122B2
公开(公告)日：2011-04-19
申请号：US12537147
申请日：2009-08-06
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： A61K31/4709 , A61K31/4725 , C07D217/04 , C07D215/06
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I); and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供具有式（I）的化合物; 和其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和本领域和亚类所述，并另外提供其药物组合物及其使用方法 用于治疗由细胞粘附分子（例如，LFA-1）的CD11 / CD18家族介导的病症。
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公开(公告)号：US20100093693A1
公开(公告)日：2010-04-15
申请号：US12537147
申请日：2009-08-06
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： A61K31/4725 , C07D217/00 , C07D401/02 , C07D401/14
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I); and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供具有式（I）的化合物; 和其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和本领域和亚类所述，并另外提供其药物组合物及其使用方法 用于治疗由细胞粘附分子（例如，LFA-1）的CD11 / CD18家族介导的病症。
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公开(公告)号：US20110124625A1
公开(公告)日：2011-05-26
申请号：US13021013
申请日：2011-02-04
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： A61K31/4709 , C07D409/14 , C07D401/12 , C07D217/18 , C07D405/14 , C07D409/12 , C07D401/14 , A61K31/506 , A61P37/00 , A61P29/00
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
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公开(公告)号：US20080176896A1
公开(公告)日：2008-07-24
申请号：US11978388
申请日：2007-10-29
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： A61K31/47 , A61P37/00 , C07D217/00
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
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公开(公告)号：US07314938B2
公开(公告)日：2008-01-01
申请号：US10982463
申请日：2004-11-05
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： C07D217/14 , A61K31/166
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供具有式（I）的化合物及其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E， L和AR 1如本文所述的一般类型和亚类所述，并且另外提供其药物组合物及其用于治疗由CD11 / CD18家族介导的细胞粘附的疾病的方法 分子（如LFA-1）。
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公开(公告)号：US07745460B2
公开(公告)日：2010-06-29
申请号：US11978388
申请日：2007-10-29
申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
IPC分类号： A61K31/166 , C07D217/14
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供了具有式（I）的化合物及其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和类别和亚类所述，另外 提供其药物组合物及其用于治疗CD11 / CD18家族细胞粘附分子（例如LFA-1）介导的病症的方法。
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公开(公告)号：US08084047B2
公开(公告)日：2011-12-27
申请号：US12508367
申请日：2009-07-23
申请人： Wang Shen , Johan D. Oslob , Kenneth Barr , Min Zhong
发明人： Wang Shen , Johan D. Oslob , Kenneth Barr , Min Zhong
CPC分类号： A61K31/4725 , A61B3/101 , A61B3/145 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0053 , A61K31/197 , A61K31/198 , A61K31/275 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4162 , A61K31/4184 , A61K31/4192 , A61K31/44 , A61K31/4709 , A61K31/472 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K33/00 , A61K33/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K38/1703 , A61K45/06 , C07C279/28 , C07C317/50 , C07D207/06 , C07D217/00 , C07D217/02 , C07D217/06 , C07D217/20 , C07D217/26 , C07D307/52 , C07D333/38 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , G01N33/5011 , G01N33/5032 , G01N33/5047 , G01N33/566 , G01N33/6872 , G01N2333/705 , G01N2333/70525 , G01N2333/70546 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/16 , Y10S514/912 , Y10S514/914
摘要： The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
摘要翻译： 本发明提供了用于治疗LFA-1介导的疾病的化合物和方法。 特别地，本文描述了LFA-1拮抗剂，并且这些拮抗剂用于治疗LFA-1介导的疾病。 在患者被诊断患有LFA-1介导的疾病之后，本发明的一个方面提供LFA-1介导的疾病的诊断和LFA-1拮抗剂的施用。 在一些实施方案中，治疗的LFA-1介导的疾病是干眼症。 本文还提供了用于鉴定LFA-1拮抗剂的化合物的方法。
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