公开(公告)号：US5788951A

公开(公告)日：1998-08-04

申请号：US826846

申请日：1997-04-08

申请人： John C. Blake-Haskins ,  Mary L. Colligan ,  Michael A. Collins ,  Benjamin Y. Mandanas ,  Abdul Gaffar

发明人： John C. Blake-Haskins ,  Mary L. Colligan ,  Michael A. Collins ,  Benjamin Y. Mandanas ,  Abdul Gaffar

IPC分类号： A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/25 ,  A61K2800/88

摘要： A composition and method is disclosed for fluoridating teeth using a two component dentifrice system in which the first component is stable, semi-solid, extrudable dentifrice composition containing a fluoride ion releasable hydrolyzable complex fluoride compound such as sodium fluorosilicate, in an aqueous vehicle in which a carrageenan gum having major kappa and lambda forms as the primary thickening agent and the abrasive is a silica providing an acid pH when slurried with water, and the second component is a semi-solid, extrudable dentifrice composition containing a calcium ion releasable compound and the abrasive and carrageenan gum in an aqueous vehicle. The first and second dentifrice compounds are maintained separate from the other until mixed for application to teeth.

摘要翻译： 公开了一种组合物和方法，其用于使用双组分洁牙剂体系氟化牙齿，其中第一组分是稳定的半固体可挤出洁齿剂组合物，其在水性载体中含有氟离子可释放的可水解复合氟化物如氟硅酸钠，其中 具有主要κ和λ形式作为主要增稠剂的角叉菜胶，磨料是当与水浆化时提供酸性pH的二氧化硅，第二组分是含有钙离子可释放化合物的半固体可挤出洁牙剂组合物， 研磨剂和角叉菜胶在水性载体中。 第一和第二洁牙剂化合物与另一种洁牙剂化合物保持分开，直到混合以施用于牙齿。

公开(公告)号：US5496540A

公开(公告)日：1996-03-05

申请号：US179272

申请日：1994-01-10

申请人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

发明人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

IPC分类号： A61K8/04 ,  A61K8/24 ,  A61K8/34 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC分类号： A61K8/046 ,  A61K8/24 ,  A61K8/347 ,  A61Q11/00 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902

摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.

摘要翻译： 包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少 牙齿被包装在分配容器中，该分配容器包括与抗菌剂相容的固体聚合物材料，例如聚氟乙烯，从而避免了这种药剂在储存时过度的抗斑块活性损失。 或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用由稳定剂如萜烯的存在来抵消，例如， 柠檬烯，口服组合物配方。 口服组合物优选含有聚乙烯基醚 - 马来酸酐共聚物的氟化物离子源，多磷酸盐的抗牙垢比例，多磷酸盐的稳定化比例（与氟化物源结合）的牙齿硬化比例， 和用于口服制剂的正常佐剂。 抑制牙齿斑块发展的方法也在本发明的范围内，含有有效量的本发明洁牙剂的清洁用品也是如此。

公开(公告)号：US5167951A

公开(公告)日：1992-12-01

申请号：US505628

申请日：1990-04-06

申请人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

发明人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

IPC分类号： A61K8/34 ,  A61K8/81 ,  A61Q11/00

CPC分类号： A61K8/347 ,  A61K8/81 ,  A61K8/8164 ,  A61Q11/00 ,  A61K2800/87 ,  Y10S514/90 ,  Y10S514/901

摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.

摘要翻译： 包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少 牙齿被包装在分配容器中，该分配容器包括与抗菌剂相容的固体聚合物材料，例如聚氟乙烯，从而避免了这种药剂在储存时过度的抗斑块活性损失。 或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用由稳定剂如萜烯的存在来抵消，例如， 柠檬烯，口服组合物配方。 口服组合物优选含有聚乙烯基醚 - 马来酸酐共聚物的氟化物离子源，多磷酸盐的抗牙垢比例，多磷酸盐的稳定化比例（与氟化物源结合）的牙齿硬化比例， 和用于口服制剂的正常佐剂。 抑制牙齿斑块发展的方法也在本发明的范围内，含有有效量的本发明洁牙剂的清洁用品也是如此。

公开(公告)号：US5135738A

公开(公告)日：1992-08-04

申请号：US427660

申请日：1989-10-26

申请人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

发明人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

IPC分类号： A61K8/34 ,  A61K8/81 ,  A61Q11/00

CPC分类号： A61Q11/00 ,  A61K8/347 ,  A61K8/8164 ,  A61K2800/87 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902

摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque acitivity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.

摘要翻译： 包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少 牙齿被包装在分配容器或瓶子中，该分配容器或瓶子包括与抗菌剂相容的固体聚合材料，例如聚氟乙烯，从而避免了这种药剂在储存时过量的抗斑块活性丧失。 或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用通过稳定剂如萜烯的存在来抵消，例如苎烯 ，在口服组合物配方中。 还描述了抑制牙齿斑块发展的方法。

公开(公告)号：US5279813A

公开(公告)日：1994-01-18

申请号：US931622

申请日：1992-08-18

申请人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

发明人： Abdul Gaffar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

IPC分类号： A61K8/04 ,  A61K8/24 ,  A61K8/34 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61K8/046 ,  A61K8/24 ,  A61K8/347 ,  A61Q11/00 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902

摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.

摘要翻译： 包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少 牙齿被包装在分配容器中，该分配容器包括与抗菌剂相容的固体聚合物材料，例如聚氟乙烯，从而避免了这种药剂在储存时过度的抗斑块活性损失。 或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用通过稳定剂如萜烯的存在来抵消，例如苎烯 ，在口服组合物配方中。 口服组合物优选含有聚乙烯基醚 - 马来酸酐共聚物的氟化物离子源，多磷酸盐的抗牙垢比例，多磷酸盐的稳定化比例（与氟化物源结合）的牙齿硬化比例， 和用于口服制剂的正常佐剂。 抑制牙齿斑块发展的方法也在本发明的范围内，含有有效量的本发明洁牙剂的清洁用品也是如此。

公开(公告)号：US5690913A

公开(公告)日：1997-11-25

申请号：US688322

申请日：1996-07-30

申请人： Donald P. Hsu ,  Rajnish Kohli ,  Richard J. Crawford ,  Nagarj S. Dixit ,  Michael A. Collins ,  David B. Viscio

发明人： Donald P. Hsu ,  Rajnish Kohli ,  Richard J. Crawford ,  Nagarj S. Dixit ,  Michael A. Collins ,  David B. Viscio

IPC分类号： A61K20060101 ,  A61K8/19 ,  A61K8/22 ,  A61K33/40 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC分类号： A61K8/22 ,  A61K8/0237 ,  A61K8/19 ,  A61Q11/00 ,  A61K2800/88

摘要： An extrudable composite multilayer dentifrice composition for cleaning teeth containing reactive bicarbonate and peroxide ingredients which do not interact during storage or when extruded together from a container onto a toothbrush but react in the oral cavity when mixed during tooth brushing, the composition comprising two separate dentifrice components, one component containing a peroxide ingredient and the other component containing a colorant reactive with the peroxide ingredient, the components having substantially equivalent viscosity which are maintained in stable discrete layered phases in interfacial contact with each other prior to extrusion without interaction of the peroxide and the colorant and which are extrudable together in interfacial contact without interaction of the ingredients.

摘要翻译： 一种可挤出复合多层洁牙剂组合物，用于清洁含有反应性碳酸氢盐和过氧化物成分的牙齿，所述牙齿含有反应性碳酸氢盐和过氧化物成分，其在储存过程中不相互作用，或者当从牙齿容器挤出到牙刷上而在牙刷期间混合时在口腔中反应， ，含有过氧化物成分的一种组分和含有与过氧化物成分反应的着色剂的其它组分，该组分具有基本上相等的粘度，其保持在稳定的离散层状相之间，在挤出之前彼此界面接触而不与过氧化物和 着色剂，并且它们可以一起挤出在界面接触中，而不与成分相互作用。

公开(公告)号：US5730959A

公开(公告)日：1998-03-24

申请号：US790348

申请日：1997-01-24

申请人： Michael Prencipe ,  Michael A. Collins

发明人： Michael Prencipe ,  Michael A. Collins

IPC分类号： A61K8/24 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/20

CPC分类号： A61K8/24 ,  A61Q11/00

摘要： A storage stable aqueous oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein from about 10% to up to about 15% by weight water, an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of relatively high amounts of water affect the stability of the composition.

摘要翻译： 一种储存稳定的含水口服组合物，其对于结石是有效的，其含有约10％至至多约15％重量的水掺入其中的口服可接受的载体，约0.5至约2％重量的水的有效抗结石组合 可溶性焦磷酸盐和约0.5至约3重量％的水溶性多磷酸盐。 在组合物中存在相当大量的水会影响组合物的稳定性。

公开(公告)号：US5913656A

公开(公告)日：1999-06-22

申请号：US970300

申请日：1997-11-14

申请人： Michael A. Collins

发明人： Michael A. Collins

IPC分类号： B65H29/00 ,  B65H29/16 ,  B65H29/34 ,  B65H29/66 ,  B65H39/04 ,  B65H39/06 ,  B65G59/00 ,  B65H5/26

CPC分类号： B65H29/6681 ,  B65H29/001 ,  B65H29/16 ,  B65H29/34 ,  B65H39/04 ,  B65H39/06 ,  Y10S414/115

摘要： Two shingled streams of signatures are stacked independently of each other in separate stacking bins that are aligned vertically one above the other and also vertically aligned with the collection bin of a re-feeder. The collection bin is replenished periodically by stopping the shingled streams and unloading the contents of the lower and upper stacking bins to form a combined stack of signatures in the re-feeder collection bin. Signatures in the re-feeder collection bin are delivered by an out-feed conveyor belt in a single reshingled stream of signatures to an in-line processing station. In an alternative embodiment, the stacking bins are laterally separated with respect to each other for separately stacking signatures from two incoming shingled streams that are being output from separate web presses or other independent sources. The incoming signatures are separately stacked and the stacks are periodically unloaded onto separate stacking tables on laterally opposite sides of a common re-feeder. The signature stacks are separately delivered at different times into the re-feeder collection bin, thereby forming a combined stack of signatures that are subsequently reshingled into a single running stream.

摘要翻译： 两个带状的签名流在独立的堆叠箱中彼此独立地堆叠，这些堆叠箱垂直地一个在另一个之上并且还与再供给器的收集箱垂直对准。 收集箱通过停止带状流和卸载下层和上层堆叠箱的内容物来定期补充，以在再供料器收集箱中形成组合的签名堆叠。 再送料收集箱中的签名由输送输送带在单个重新排列的签名流中传送到在线处理站。 在替代实施例中，堆叠箱相对于彼此横向分离，以从两个从分离的卷筒纸压榨机或其他独立的源输出的两个进入的带状混合流中分开堆叠签名。 进入的签名被分开堆叠，并且堆叠被周期地卸载到共同的再馈送器的横向相对侧上的分开的堆叠表上。 签名堆栈在不同的时间被分开地传送到再馈送器收集箱中，从而形成一组组合的签名，随后将它们重新映射到单个运行流中。

公开(公告)号：US5849267A

公开(公告)日：1998-12-15

申请号：US859506

申请日：1997-05-20

申请人： Michael A. Collins ,  Richard J. Crawford ,  Donald W. Clipper

发明人： Michael A. Collins ,  Richard J. Crawford ,  Donald W. Clipper

IPC分类号： A61K8/19 ,  A61K8/24 ,  A61K8/55 ,  A61K8/73 ,  A61K8/81 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC分类号： A61K8/24 ,  A61K8/19 ,  A61K8/55 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8164 ,  A61Q11/00 ,  A61K2800/5424 ,  A61K2800/594

摘要： A desensitizing anti-tartar dentifrice of low stringiness upon extrusion from a tube or other container onto a toothbrush is provided which also retains desirable cream or gel consistency without becoming thick and difficult to extrude and retains phase integrity without substantial separation, which contains polyphosphate or phosphono compound anti-tartar agent and potassium salt tooth pain inhibitor and in which the gelling agent is a mixture of alkali metal carboxymethyl cellulose, (CMC) and xanthan, wherein the CMC contains about 1.0 to 1.5 carboxymethyl groups per anhydroglycose unit.

摘要翻译： 提供从管或其他容器挤出到牙刷上时具有低拉丝性的脱敏抗牙垢洁牙剂，其还保留所需的乳膏或凝胶稠度，而不变厚并且难以挤出并保持相位完整性而没有基本分离，其含有多磷酸盐或膦酰基 复合抗牙垢剂和钾盐牙齿疼痛抑制剂，其中胶凝剂是碱金属羧甲基纤维素（CMC）和黄原胶的混合物，其中CMC含有每个脱水糖苷单元约1.0-1.5个羧甲基。

公开(公告)号：US5273741A

公开(公告)日：1993-12-28

申请号：US922252

申请日：1992-07-30

申请人： Abdul Gaftar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

发明人： Abdul Gaftar ,  Richard S. Robinson ,  Jeffrey Miller ,  Chimpiramma Potini ,  Michael A. Collins ,  Theresa G. Shackil

IPC分类号： A61K8/34 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/26

CPC分类号： A61Q11/00 ,  A61K8/347 ,  A61K2800/87 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902

摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.

摘要翻译： 包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少 牙齿包装在分配容器或瓶子中，该分配容器或瓶子包括与抗菌剂相容的诸如聚氟乙烯的固体聚合物材料，从而避免了这种药剂在储存时过度的抗斑块活性损失。 或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用通过稳定剂如萜烯的存在来抵消，例如苎烯 ，在口服组合物配方中。 还描述了抑制牙齿斑块发展的方法。