公开(公告)号：US07125550B2

公开(公告)日：2006-10-24

申请号：US10181611

申请日：2001-01-19

申请人： John C. Herr ,  Friederike Jayes ,  Arabinda Mandal ,  Jagathpala Shetty ,  Michael J. Wolkowicz

发明人： John C. Herr ,  Friederike Jayes ,  Arabinda Mandal ,  Jagathpala Shetty ,  Michael J. Wolkowicz

IPC分类号： A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C12N5/00 ,  C12N5/02

CPC分类号： C12N9/2462 ,  A61K39/0006 ,  C07K16/40 ,  C12Y302/01017 ,  G01N2500/00 ,  Y10S514/841

摘要： The present invention relates to two novel, testis-specific proteins (C19 and C23) that arc lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the design of contraceptive agents. The C19 and C23 proteins can also be modified to establish lysozyme activity and the modified proteins can then be used in all applications that currently exist for lysozymes.

公开(公告)号：US20060062799A1

公开(公告)日：2006-03-23

申请号：US11269323

申请日：2005-11-08

申请人： John Herr ,  Friederike Jayes ,  Arabinda Mandal ,  Jagathpala Shetty ,  Michael Wolkowicz

发明人： John Herr ,  Friederike Jayes ,  Arabinda Mandal ,  Jagathpala Shetty ,  Michael Wolkowicz

IPC分类号： A61K39/00 ,  C12N9/36 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12Y302/01017 ,  C12N9/2462

摘要： The present invention relates to two novel, testis-specific proteins (C19 and C23) that are lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the design of contraceptive agents. The C19 and C23 proteins can also be modified to establish lysozyme activity and the modified proteins can then be used in all applications that currently exist for lysozymes.

摘要翻译： 本发明涉及两种新型的睾丸特异性蛋白（C19和C23），它们是溶菌酶旁系同源物。 据信这些蛋白质在精子获能和卵子受精中起作用。 因此，这些化合物是设计避孕药物的理想目标。 也可以修饰C19和C23蛋白以建立溶菌酶活性，然后将修饰的蛋白质用于目前存在于溶菌酶的所有应用中。