摘要:
The use of calcium channel blocker compounds as antitumor and antimetastatic agents in mammals in vivo and in standard laboratory experimets with tumor cells in vitro is described. In particular the use of nimodipine (Bay e 9736) or nifedipine (Bay a 1040) and structurally related compounds as described.
摘要翻译:描述了钙通道阻滞剂化合物在体内在哺乳动物中的抗肿瘤和抗转移剂以及体外肿瘤细胞的标准实验室实验中的用途。 特别是使用如所述的尼莫地平(Bay e 9736)或硝苯地平(Bay a 1040)和结构相关的化合物。
摘要:
Novel nitrone substituted 4-aryl dihydropyridines of the formula: ##STR1## are described along with a process for their preparation. The compounds exhibit calcium channel blocker and antimetastatic acitivity.
摘要:
Compositions and a method for inhibiting tumor cell induced platelet aggregation are described. Platelet aggregation by tumor cells is part of the metastatic cascade which is interrupted according to the present invention. The compounds include a mixture of at least two members of the group including a calcium channel blocker, a prostacyclin, a thromboxane synthase inhibitor and a phosphodiesterase inhibitor. All of the compounds utilized have an affect on calcium ion which controls platelet aggregation.
摘要:
A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two separate dosages of each compound so as to produce regression of the tumor in vitro and in vivo and inhibition of metastasis of the tumor in vivo.
摘要:
A system and method for allocating inventory to satisfy online demand and demand at physical locations includes allocating a first portion of media rental inventory for online fulfillment and a second portion for fulfillment at physical rental locations. The method further includes making a determination of in-store rental activity for the second portion of inventory, and reallocating the first and second portions of inventory based on that determination.
摘要:
The invention is directed to a night vision system that has an illuminator that transmits light towards a target using light outside the visible spectrum. A receive optics focuses an image on a charge coupled device. This system with an ultraviolet illuminator allows the night vision system to view images beyond 2500 meters, while present systems are limited to around 800 meters. The illuminator is generally a high peak power pulsed light source. A processor uses frame addition techniques to increase the captured light and may use binning techniques to increase the signal to noise ratio. The system may use multiple illuminators and capture images at a number of different wavelengths.
摘要:
A firearm projectile includes a precision-machined outer component having a generally cylindrical body, a tip at the forward end of the body, a base at the rear end of the body, and a precision-machined cavity machined into the outer component. A precision-machined inner component is pressed into the cavity. The outer component includes a homogenous material that is softer than firearm barrel steel. The inner component includes a material having a higher density than the outer component and a higher density than an armor plate, such as solid tungsten, tungsten carbide and potential some Nanotechnology materials such as NanoSteel™. A cap may be attached to the outer component to seal the inner component inside the cavity. The cavity can be machined from the front or rear end of the outer component. The cap fits into the rear of the projectile or may be a bullet tip. The cavity and the inner component may be cylindrical or tapered.
摘要:
An elongated plunger is slidably connected at one end with one end of a sleeve for telescoping movement into the sleeve. The other end portion of the sleeve releasably supports a cannula to be inserted at one end through the skin and stomach wall of a bloated animal. Flexible wing members on the pointed end portion of the cannula normally maintains the inserted end portion of the cannula within the animal's stomach. A stop, slidably surrounding the other end portion of the cannula, maintains one end portion of the cannula projecting outwardly of the animal's skin.
摘要:
A system and method for fulfilling a media request includes receiving a media request associated with a subscriber account. One inventory location is selected from a plurality of inventory locations to fulfill the media request, and at least one of the inventory locations accommodates in-store media rental requests.