公开(公告)号：US20070179406A1

公开(公告)日：2007-08-02

申请号：US11704186

申请日：2007-02-09

申请人： John DeNuzzio ,  Steven Keith ,  Lawrence Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd Chelak ,  Robert West ,  William Allen ,  Frederick Karl ,  Lee Griswold

发明人： John DeNuzzio ,  Steven Keith ,  Lawrence Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd Chelak ,  Robert West ,  William Allen ,  Frederick Karl ,  Lee Griswold

IPC分类号： A61B5/00 ,  G01N33/487

CPC分类号： A61B5/1486 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150725 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T29/49002 ,  Y10T29/49826

摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

公开(公告)号：US08808321B2

公开(公告)日：2014-08-19

申请号：US12929261

申请日：2011-01-11

申请人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

发明人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

IPC分类号： A61B17/14 ,  A61B17/32 ,  A61B5/00 ,  B65D81/00

CPC分类号： A61B5/1486 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150725 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T29/49002 ,  Y10T29/49826

摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

摘要翻译： 提供了与传感带集成的穿刺装置及其制造和使用方法。 喷枪和分析物感测带组合在单个，优选一次性的装置中。 在优选实施例中，在支撑构件中设置狭槽，使得喷枪可以由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。 传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

公开(公告)号：US20120011705A1

公开(公告)日：2012-01-19

申请号：US12929261

申请日：2011-01-11

申请人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

发明人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

IPC分类号： H05K13/00 ,  B23P11/00

CPC分类号： A61B5/1486 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150725 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T29/49002 ,  Y10T29/49826

摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

摘要翻译： 提供了与传感带集成的穿刺装置及其制造和使用方法。 喷枪和分析物感测带组合在单个，优选一次性的装置中。 在优选实施例中，在支撑构件中设置狭槽，使得喷枪可以由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。 传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

公开(公告)号：US07192405B2

公开(公告)日：2007-03-20

申请号：US10259798

申请日：2002-09-30

申请人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

发明人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150725 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T29/49002 ,  Y10T29/49826

摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

摘要翻译： 提供了与传感带集成的穿刺装置及其制造和使用方法。 喷枪和分析物感测带组合在单个，优选一次性的装置中。 在优选实施例中，在支撑构件中设置狭槽，使得喷枪能够由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。 传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

公开(公告)号：US07959583B2

公开(公告)日：2011-06-14

申请号：US11704186

申请日：2007-02-09

申请人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

发明人： John D. DeNuzzio ,  Steven Keith ,  Lawrence A. Monahan ,  Phyllis Palmer ,  Bill Stewart ,  Todd M. Chelak ,  Robert E. West ,  William Allen ,  Frederick Karl ,  Lee Griswold

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150725 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T29/49002 ,  Y10T29/49826

摘要： A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

摘要翻译： 提供了与传感带集成的穿刺装置及其制造和使用方法。 喷枪和分析物感测带组合在单个，优选一次性的装置中。 在优选实施例中，在支撑构件中设置狭槽，使得喷枪可以由喷枪驱动器接合并被驱动到皮肤中，从伤口产生体液样品。 传感带的传感区域与伤口位置相邻，可减少对患者的灵活性要求。

公开(公告)号：US20050148003A1

公开(公告)日：2005-07-07

申请号：US11002157

申请日：2004-12-02

申请人： Steven Keith ,  Phyllis Palmer

发明人： Steven Keith ,  Phyllis Palmer

IPC分类号： G01N21/77 ,  G01N33/542 ,  G01N33/543 ,  C12Q1/68 ,  G01K11/00 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G06F19/00

CPC分类号： G01N21/7703 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B2560/0252 ,  G01N21/274 ,  G01N21/6428 ,  G01N33/542 ,  G01N33/54373 ,  G01N2021/7786 ,  G01N2201/1211

摘要： The invention is directed to methods of correcting a luminescence value, and methods of determining a corrected analyte concentration, by use of a device capable of providing a signal when a binding protein binds to at least one analyte, and a thermometer. The invention is also directed to systems which include such a device, and a processor for correcting measured luminescence of a reporter group based on a measured temperature. The invention is further directed to apparatuses that include a memory for storing luminescence information and temperature information, and a processor for correcting luminescence information. The invention is further directed to computer programs for executing the methods of the invention, and machine-readable storage medium on which programs are recorded.

摘要翻译： 本发明涉及通过使用能够在结合蛋白结合至少一种分析物时提供信号的装置和温度计来校正发光值的方法和确定校正的分析物浓度的方法。 本发明还涉及包括这种装置的系统，以及用于基于测量的温度来校正报告基团的测量的发光的处理器。 本发明还涉及包括用于存储发光信息和温度信息的存储器以及用于校正发光信息的处理器的装置。 本发明进一步涉及用于执行本发明的方法的计算机程序和其上记录有程序的机器可读存储介质。

公开(公告)号：US20110275061A1

公开(公告)日：2011-11-10

申请号：US12531508

申请日：2008-03-20

申请人： Kristin Weidemaier ,  Christian Sandmann ,  W. Shannon Dillmore ,  James L. Schram ,  W. William Stewart ,  Robert E. Pearson ,  Helen Hsieh ,  Steven Keith ,  Rajendra R. Bhat ,  Andrea Liebmann-Vinson ,  Adam Craig Curry ,  Alexander G. Lastovich

发明人： Kristin Weidemaier ,  Christian Sandmann ,  W. Shannon Dillmore ,  James L. Schram ,  W. William Stewart ,  Robert E. Pearson ,  Helen Hsieh ,  Steven Keith ,  Rajendra R. Bhat ,  Andrea Liebmann-Vinson ,  Adam Craig Curry ,  Alexander G. Lastovich

IPC分类号： G01N21/65 ,  C12Q1/68 ,  C12Q1/02 ,  G01N21/75 ,  C07F19/00 ,  C07K17/00 ,  C07F1/12 ,  G01N30/00 ,  B29C35/08 ,  C12Q1/00 ,  G01N33/53 ,  B82Y15/00

CPC分类号： G01N33/587 ,  G01N21/658 ,  G01N33/54333

摘要： Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

摘要翻译： 本文公开了使用表面增强拉曼光谱（SERS）活性颗粒的诊断测定，包括基于液体的测定; 磁捕获测定; 在测定中用于信号放大的微粒 - 纳米颗粒卫星结构; 用于增强靶标检测的复合SERS活性粒子; 和样品管及其使用方法。

公开(公告)号：US07060059B2

公开(公告)日：2006-06-13

申请号：US10683466

申请日：2003-10-14

申请人： Steven Keith ,  Robert S. Parker ,  Noel G. Harvey ,  Ronald J. Pettis ,  John D. DeNuzzio ,  Glenn Vonk

发明人： Steven Keith ,  Robert S. Parker ,  Noel G. Harvey ,  Ronald J. Pettis ,  John D. DeNuzzio ,  Glenn Vonk

IPC分类号： A61M31/00

CPC分类号： A61K38/28 ,  A61M5/172 ,  A61M31/002 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

摘要： A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.

摘要翻译： 一种闭环治疗系统，用于控制使用者身体中物质的浓度，例如血糖浓度。 该系统和方法采用测量体内葡萄糖水平的传感器系统，使用测量的葡萄糖水平产生输出的控制器，该输出可用于自动或手动地控制皮内胰岛素输注系统以设定恒定或时间 - 使用者的目标血糖浓度变化，然后将适量的胰岛素注入使用者的身体，以达到和维持血糖浓度的目标值。

公开(公告)号：US09823253B2

公开(公告)日：2017-11-21

申请号：US12531508

申请日：2008-03-20

申请人： Kristin Weidemaier ,  Christian Sandmann ,  W. Shannon Dillmore ,  James L. Schram ,  W. William Stewart ,  Robert E. Pearson ,  Helen Hsieh ,  Steven Keith ,  Rajendra R. Bhat ,  Andrea Liebmann-Vinson ,  Adam Craig Curry ,  Alexander G. Lastovich

发明人： Kristin Weidemaier ,  Christian Sandmann ,  W. Shannon Dillmore ,  James L. Schram ,  W. William Stewart ,  Robert E. Pearson ,  Helen Hsieh ,  Steven Keith ,  Rajendra R. Bhat ,  Andrea Liebmann-Vinson ,  Adam Craig Curry ,  Alexander G. Lastovich

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/58 ,  G01N21/65 ,  G01N33/543

CPC分类号： G01N33/587 ,  G01N21/658 ,  G01N33/54333

摘要： Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

公开(公告)号：US07787923B2

公开(公告)日：2010-08-31

申请号：US10967220

申请日：2004-10-19

申请人： Javier Alarcon ,  Kristin Weidemaier ,  Terry J. Amis ,  John D. DeNuzzio ,  Christopher C. Herdman ,  Ross W. Jacobson ,  J. Bruce Pitner ,  Douglas B. Sherman ,  Steven Keith

发明人： Javier Alarcon ,  Kristin Weidemaier ,  Terry J. Amis ,  John D. DeNuzzio ,  Christopher C. Herdman ,  Ross W. Jacobson ,  J. Bruce Pitner ,  Douglas B. Sherman ,  Steven Keith

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6848 ,  A61B2560/0223 ,  G01N21/274 ,  G01N21/7703 ,  G01N33/542 ,  G01N33/54373 ,  G01N2021/7786 ,  G01N2201/1211

摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

摘要翻译： 公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。 感测元件连接到光学导管的远端，并且包含适于与至少一种靶分析物结合的至少一种结合蛋白。 感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。 可选地，光学导管和感测元件可以容纳在插管斜面内。