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1.发明授权System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device 有权用于使用耦合到单针或多针皮内（ID）递送装置的反馈或基于模型的控制器来启动和维持对患者物质浓度的连续长期控制的系统和方法公开(公告)号：US07060059B2
公开(公告)日：2006-06-13
申请号：US10683466
申请日：2003-10-14
申请人： Steven Keith , Robert S. Parker , Noel G. Harvey , Ronald J. Pettis , John D. DeNuzzio , Glenn Vonk
发明人： Steven Keith , Robert S. Parker , Noel G. Harvey , Ronald J. Pettis , John D. DeNuzzio , Glenn Vonk
IPC分类号： A61M31/00
CPC分类号： A61K38/28 , A61M5/172 , A61M31/002 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63
摘要： A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.
摘要翻译： 一种闭环治疗系统，用于控制使用者身体中物质的浓度，例如血糖浓度。 该系统和方法采用测量体内葡萄糖水平的传感器系统，使用测量的葡萄糖水平产生输出的控制器，该输出可用于自动或手动地控制皮内胰岛素输注系统以设定恒定或时间 - 使用者的目标血糖浓度变化，然后将适量的胰岛素注入使用者的身体，以达到和维持血糖浓度的目标值。
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公开(公告)号：US08465468B1
公开(公告)日：2013-06-18
申请号：US09606909
申请日：2000-06-29
申请人： Ronald J. Pettis , James A. Down , Noel G. Harvey
发明人： Ronald J. Pettis , James A. Down , Noel G. Harvey
IPC分类号： A61M31/00
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.
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3.发明申请公开(公告)号：US20110190725A1
公开(公告)日：2011-08-04
申请号：US13072824
申请日：2011-03-28
申请人： Ronald J. Pettis , Noel G. Harvey , James A. Down
发明人： Ronald J. Pettis , Noel G. Harvey , James A. Down
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.
摘要翻译： 一种用于直接递送的方法，其中物质被引入到哺乳动物皮肤内的真皮内空间，其涉及通过至少一个具有暴露高度在0和1mm之间的出口的小规模中空针管来施用该物质。 将出口插入到皮肤中至0.3mm至2mm之间的深度，使得物质的输送发生在0.3mm和2mm之间的深度。
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4.发明授权Device for withdrawing or administering a substance and method of manufacturing a device 有权用于取出或管理物质的装置和制造装置的方法公开(公告)号：US06607513B1
公开(公告)日：2003-08-19
申请号：US09590062
申请日：2000-06-08
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译： 一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。 该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。 多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。 联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。 皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。
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5.发明授权Method for altering drug pharmacokinetics based on medical delivery platform 有权基于医疗交付平台改变药物药代动力学的方法公开(公告)号：US08708994B2
公开(公告)日：2014-04-29
申请号：US13072824
申请日：2011-03-28
申请人： Ronald J. Pettis , Noel G. Harvey , James A. Down
发明人： Ronald J. Pettis , Noel G. Harvey , James A. Down
IPC分类号： A61M31/00
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.
摘要翻译： 一种用于直接递送的方法，其中物质被引入到哺乳动物皮肤内的真皮内空间，其涉及通过至少一个具有暴露高度在0和1mm之间的出口的小规模中空针管来施用该物质。 将出口插入到皮肤中至0.3mm至2mm之间的深度，使得物质的输送发生在0.3mm和2mm之间的深度。
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公开(公告)号：US20160207253A9
公开(公告)日：2016-07-21
申请号：US13442933
申请日：2012-04-10
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
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7.发明授权公开(公告)号：US08172815B2
公开(公告)日：2012-05-08
申请号：US10443822
申请日：2003-05-23
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译： 一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。 该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。 多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。 联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。 皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。
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8.发明申请公开(公告)号：US20080147042A1
公开(公告)日：2008-06-19
申请号：US11932303
申请日：2007-10-31
申请人： Ronald J. Pettis , Noel G. Harvey , James A. Down
发明人： Ronald J. Pettis , Noel G. Harvey , James A. Down
IPC分类号： A61M5/178
CPC分类号： A61M37/0015 , A61K38/193 , A61K38/21 , A61K38/28 , A61M5/158 , A61M5/282 , A61M5/3202 , A61M5/3278 , A61M5/46 , A61M2202/0445
摘要： Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.
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9.发明申请公开(公告)号：US20080118507A1
公开(公告)日：2008-05-22
申请号：US11932272
申请日：2007-10-31
申请人： Ronald J. Pettis , Noel G. Harvey , James A. Down
发明人： Ronald J. Pettis , Noel G. Harvey , James A. Down
IPC分类号： A61K39/395
CPC分类号： A61M37/0015 , A61K38/193 , A61K38/21 , A61K38/28 , A61M5/158 , A61M5/282 , A61M5/3202 , A61M5/3278 , A61M5/46 , A61M2202/0445
摘要： Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.
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10.发明授权公开(公告)号：US09717451B2
公开(公告)日：2017-08-01
申请号：US13442933
申请日：2012-04-10
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
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