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1.发明申请Materials and methods for the generation of fully 2'-modified nucleic acid transcripts 有权用于产生完全2'-修饰的核酸转录物的材料和方法公开(公告)号：US20070117112A1
公开(公告)日：2007-05-24
申请号：US11480188
申请日：2006-06-30
申请人： John Diener , Anthony Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
发明人： John Diener , Anthony Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2330/30 , C12Q1/6846 , C12Q1/6865 , G01N2333/9125 , C12Q2525/117 , C12Q2521/119 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
摘要翻译： 提供材料和方法用于产生具有并入其序列的完全修饰的三磷酸核苷酸的适体治疗剂。
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2.发明授权Materials and methods for the generation of fully 2′-modified nucleic acid transcripts 有权用于产生完全2'-修饰的核酸转录物的材料和方法公开(公告)号：US08105813B2
公开(公告)日：2012-01-31
申请号：US11480188
申请日：2006-06-30
IPC分类号： C12N9/12
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2330/30 , C12Q1/6846 , C12Q1/6865 , G01N2333/9125 , C12Q2525/117 , C12Q2521/119 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
摘要翻译： 提供材料和方法用于产生具有并入其序列的完全修饰的三磷酸核苷酸的适体治疗剂。
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公开(公告)号：US20090142855A1
公开(公告)日：2009-06-04
申请号：US11988079
申请日：2006-06-30
申请人： Wei Tang , Yuxun Wang , Shuhao Zhu
发明人： Wei Tang , Yuxun Wang , Shuhao Zhu
CPC分类号： C07K14/5434
摘要： The present invention relates to the primate family of cytokines. Provided herein are polynucleotides encoding such polypeptides, and reagents useful for producing the encoded polypeptides in a host source, and for identifying compounds which bind and modulate the activity of the encoded polypeptides. Also provided are reagents useful for the diagnosis or treatment of inflammatory and/or autoimmune related diseases in primates.
摘要翻译： 本发明涉及灵长类动物细胞因子家族。 本文提供了编码此类多肽的多核苷酸，以及可用于在宿主来源中产生编码多肽的试剂，以及用于鉴定结合和调节编码多肽的活性的化合物。 还提供了可用于诊断或治疗灵长类动物中炎性和/或自身免疫相关疾病的试剂。
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4.发明申请Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics 审中-公开稳定的PSMA适应症及其作为前列腺癌治疗用途公开(公告)号：US20090105172A1
公开(公告)日：2009-04-23
申请号：US11885908
申请日：2006-03-07
申请人： John L. Diener , Paul Hatala , Jason R. Killough , Jess Wagner-Whyte , Charles Wilson , Shuhao Zhu
发明人： John L. Diener , Paul Hatala , Jason R. Killough , Jess Wagner-Whyte , Charles Wilson , Shuhao Zhu
IPC分类号： A61K31/7088 , C07H21/00 , C12Q1/68 , A61P43/00
CPC分类号： C12N15/115 , A61K47/549 , A61K51/0491 , C12N15/111 , C12N2310/16 , C12N2310/351 , C12N2320/13 , C12N2320/31 , G01N33/57434 , G01N33/57492
摘要： The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
摘要翻译： 本发明为PSMA提供稳定的高亲和力核酸配体。 本文描述了使用具有2'-O-甲基取代的核酸的SELEX TM方法和细胞表面SELEX TM来鉴定和制备新的，稳定的，高亲和力的PSMA配体的方法。 还包括使用所述核酸配体治疗和诊断以PSMA表达为特征的疾病的方法和组合物。
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5.发明授权公开(公告)号：US06329378B1
公开(公告)日：2001-12-11
申请号：US09501758
申请日：2000-02-10
申请人： Xiaodan Mei , Peng Wang , Andrei Caracoti , Pamela Mingo , Vincent Boyd , Robert Murray , Nicholas J. Sisti , Yi Bin Xiang , Shuhao Zhu , C. Richard Wobbe , Daniel Moore
发明人： Xiaodan Mei , Peng Wang , Andrei Caracoti , Pamela Mingo , Vincent Boyd , Robert Murray , Nicholas J. Sisti , Yi Bin Xiang , Shuhao Zhu , C. Richard Wobbe , Daniel Moore
IPC分类号： C07D24112
CPC分类号： C07D213/53 , C07C251/86 , C07C337/08 , C07D241/20 , C07D401/12
摘要： Disclosed are pharmaceutical compositions comprising aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, and methods for using the compositions as antifungal agents. The invention also relates to novel aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, their preparation, to pharmaceutical compositions containing them, and to methods of using them to alleviate fungal infections.
摘要翻译： 公开了包含式I和II的芳基和杂芳基腙，肼和缩氨基硫脲酮衍生物的药物组合物，以及使用该组合物作为抗真菌剂的方法。 本发明还涉及式I和II的新型芳基和杂芳基腙，肼和缩氨基硫脲酮衍生物，其制备方法，含有它们的药物组合物，以及使用它们减轻真菌感染的方法。
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