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公开(公告)号：US5704913A
公开(公告)日：1998-01-06
申请号：US246485
申请日：1994-05-19
申请人： John E. Abele , Peter M. Nicholas , James C. Wang
发明人： John E. Abele , Peter M. Nicholas , James C. Wang
CPC分类号： A61M25/104 , A61M25/1011 , A61M2025/1072 , A61M2025/1075 , A61M2025/1086
摘要： A catheter for insertion into a bodily conduit, especially an artery. The catheter comprises a shaft (26) having at least one lumen (24) for delivery of a fluid inflation media and a double balloon (12) including an array (20) of a plurality of inflatable secondary chambers (22) radially disposed in a cylindrical array around an inflatable primary chamber (16). Each of the secondary chambers (22) shares a common wall (38) with adjacent secondary chambers (22) and a common wall (14) with the primary chamber (16). The secondary chambers (22) are inflated by an array of channels (32) which are separated from each other by webs (40). One or more of the secondary chambers (22) may be in communication with a pressure transducer for measurement of the resistance of, e.g., a stenosis to dilation by the balloon (12). Alternately, a triple balloon (60) has inner secondary chambers (22a) and outer secondary chambers (22b). Also alternately, one or more of the secondary chambers (22) may be adapted to dispense medication. A method for treating a constricted bodily conduit using the catheter is also disclosed.
摘要翻译： 用于插入身体导管，特别是动脉的导管。 导管包括具有用于输送流体膨胀介质的至少一个内腔（24）的轴（26）和包括放射状设置在多个可膨胀的第二腔室（22）中的多个可充气副腔室（22）的阵列（20）的双气囊（12） 围绕可充气主室（16）的圆柱形阵列。 每个次级室（22）与相邻的副室（22）和与主室（16）的公共壁（14）共用公共壁（38）。 二次室（22）由通过腹板（40）彼此分离的通道阵列（32）而膨胀。 二次腔室（22）中的一个或多个可以与压力换能器连通，用于测量例如由球囊（12）扩张的狭窄阻力。 或者，三重气囊（60）具有内部辅助室（22a）和外部二级室（22b）。 还可以选择地，一个或多个第二腔室（22）可适于分配药物。 还公开了一种使用导管治疗收缩的身体导管的方法。
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公开(公告)号：US5478349A
公开(公告)日：1995-12-26
申请号：US234473
申请日：1994-04-28
申请人： Peter M. Nicholas
发明人： Peter M. Nicholas
CPC分类号： A61F2/958
摘要： A method and device for implanting an endoprosthesis within the lumen of a body passageway. A tubular, elongated endoprosthesis having a small outer diameter for intraluminal delivery of the selected body passageway, is capable of being progressively permanently deformed to an expanded diameter by application of outwardly acting force. The endoprosthesis is provided on a catheter having an inflatable, radially expandable balloon, the axial dimension of which is shorter than the axial dimension of the endoprosthesis. The elongated prothesis is inserted in unexpanded state into a desired location within the body passageway and with the catheter positioned so that its expandable portion registers inside a first portion of the endoprosthesis, the inflatable portion of the catheter is inflated to cause deformation of the first portion of the endoprosthesis to an expanded diameter. The inflatable portion of the catheter is then deflated and shifted axially until it registers with an unexpanded portion of the endoprosthesis and the inflation of the inflatable portion of the catheter is repeated until the elongated endoprosthesis is expanded the desired length, and the endoprosthesis is permanently placed within the lumen. With the endoprosthesis comprised at least partically of knitted wire, the long endoprosthesis is especially capable of conforming to tortuosities of the body passage.
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公开(公告)号：US06602279B1
公开(公告)日：2003-08-05
申请号：US08967240
申请日：1997-11-05
申请人： Peter M. Nicholas
发明人： Peter M. Nicholas
IPC分类号： A61F206
CPC分类号： A61F2/958
摘要： A method and device for implanting an endoprosthesis within the lumen of a body passageway. A tubular, elongated endoprosthesis having a small outer diameter for intraluminal delivery of the selected body passageway, is capable of being progressively permanently deformed to an expanded diameter by application of outwardly acting force. The endoprosthesis is provided on a catheter having an inflatable, radially expandable balloon, the axial dimension of which is shorter than the axial dimension of the endoprosthesis. The elongated prothesis is inserted in unexpanded state into a desired location within the body passageway and with the catheter positioned so that its expandable portion registers inside a first portion of the endoprosthesis, the inflatable portion of the catheter is inflated to cause deformation of the first portion of the endoprosthesis to an expanded diameter. The inflatable portion of the catheter is then deflated and shifted axially until it registers with an unexpanded portion of the endoprosthesis and the inflation of the inflatable portion of the catheter is repeated until the elongated endoprosthesis is expanded the desired length, and the endoprosthesis is permanently placed within the lumen. With the endoprosthesis comprised at least partically of knitted wire, the long endoprosthesis is especially capable of conforming to tortuosities of the body passage.
摘要翻译： 一种用于将内假体植入人体通道的内腔内的方法和装置。 具有小外径的用于腔内递送所选择的身体通道的管状细长内假体能够通过施加向外作用的力而逐渐地永久地变形到扩张的直径。 内置假体设置在具有可膨胀的可径向扩张的气囊的导管上，该气囊的轴向尺寸比内置假体的轴向尺寸短。 细长的假体以未膨胀状态插入体通道内的期望位置，并且导管被定位成使得其可扩张部分配置在内假体的第一部分内，导管的可充气部分被膨胀以引起第一部分的变形 的假体扩张直径。 然后将导管的可充气部分放气并轴向移动，直到其与内置假体的未膨胀部分配准，并重复导管的可充气部分的充气，直到细长的内用假体膨胀所需长度，并且将内假体永久放置 在管腔内。 在内部假体至少部分地由针织线组成的情况下，长内假体特别能够符合身体通道的曲折。
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公开(公告)号：US5755722A
公开(公告)日：1998-05-26
申请号：US361963
申请日：1994-12-22
CPC分类号： A61F2/958 , A61M25/0023 , A61M25/1018 , A61M25/1029 , A61F2250/0067 , A61M2025/0036 , A61M2025/004 , A61M2025/105 , A61M2025/1086 , A61M25/10 , A61M25/1027
摘要： An inflatable medical device and method for the placement of a stent in a body passageway by means of a two stage expansion of the stent and for the delivery of medications to precise location in the passageway. The device includes a catheter shaft (14) having a plurality of lumens (13, 22, 28) disposed therein. The catheter shaft has a distal end adapted to be disposed within a vascular passageway. An inflatable balloon is defined by a generally cylindrical wall and is adapted to receive inflation fluids. The balloon is disposed on the distal end of the shaft. An array of circumferentially arranged inflation conduits (40) is disposed in the wall. The conduits (40) are spaced from each other within the wall of the balloon whereby to form a annular array. An array of medication delivering conduits (25) can be disposed within the wall of the balloon. These conduits are adapted to deliver medications to predetermined locations within the body passageway being treated. A stent (30) is removably disposed around the exterior of the wall of the balloon and is expandable radially outwardly from a narrow insertion diameter to a larger second diameter by the expansion of the balloon (16) and then to a still larger third diameter by inflation of the inflation conduits (40) whereby to expand the body passageway and seat the stent.
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公开(公告)号：US5454373A
公开(公告)日：1995-10-03
申请号：US278079
申请日：1994-07-20
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： An ultrasound imaging device has a stationary, elongated flexible tubular body, a rotatable drive shaft extending through the body, and a nose member located distally of the tubular body. The nose member is mounted on the distal end of the drive shaft to rotate therewith, and an acoustic imaging instrument is incorporated in the nose member for producing acoustic images of adjacent tissue as the drive shaft turns. The nose member is covered with a bio-compatible, acoustically transparent, lubricous coating of hydrophilic material sufficient to shield and space the nose member from the adjacent tissue. The lubricous coating of hydrophilic material covers an area of the surface of the ultrasound imaging device through which the acoustic imaging instrument causes acoustic signals to pass. The coating has sufficient thickness to avoid puncturing of a wall of a blood vessel by the nose member while the nose member rotates within the blood vessel sufficiently close to the wall for puncturing otherwise to occur.
摘要翻译： 超声成像装置具有静止的细长柔性管状体，延伸穿过主体的可旋转驱动轴和位于管状体远端的鼻部构件。 鼻部构件安装在驱动轴的远端上以与其一起旋转，并且声学成像仪器结合在鼻部构件中，以在驱动轴转动时产生相邻组织的声像。 鼻部构件覆盖有亲水材料的生物相容的，透声的，润滑的涂层，其足以屏蔽鼻部构件和相邻组织的空间。 亲水材料的润滑涂层覆盖超声成像装置的表面的区域，声学成像仪器通过该区域使声信号通过。 该涂层具有足够的厚度以避免鼻部构件在鼻部构件在血管内旋转到足够靠近壁的位置时刺穿血管壁，否则发生刺穿。
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公开(公告)号：US06945995B2
公开(公告)日：2005-09-20
申请号：US10231374
申请日：2002-08-29
申请人： Peter M. Nicholas
发明人： Peter M. Nicholas
CPC分类号： A61F2/856 , A61B90/39 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/826 , A61F2002/828 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2002/91591 , A61F2210/0076 , A61F2210/009 , A61F2250/0032 , A61F2250/0048 , A61F2250/0063
摘要： A medical device and method of providing same, comprises a first stent body and a second stent body wherein the medical device is formed when the at least one first marker portion and the at least one second marker portion of the stent bodies are positioned in a predetermined alignment wherein the first stent body and the second stent body are aligned along substantially the same longitudinal axis and at least a portion of the first end region and at least a portion of the second end region of the respective stent bodies are overlappingly arranged to provide the medical device with a longitudinal length that is less than the sum of the first stent body length and the second stent body length.
摘要翻译： 一种医疗装置及其方法，包括第一支架主体和第二支架主体，其中，当支架主体的至少一个第一标记部分和至少一个第二标记部分位于预定的位置时，形成医疗装置 对准，其中第一支架主体和第二支架主体沿着基本相同的纵向轴线对准，并且相应支架体的第一端区域和第二端区域的至少一部分的至少一部分被重叠布置以提供 医疗装置的纵向长度小于第一支架主体长度和第二支架主体长度的总和。
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公开(公告)号：US5928247A
公开(公告)日：1999-07-27
申请号：US999175
申请日：1997-12-29
CPC分类号： A61F2/958 , A61M25/0023 , A61M25/1018 , A61M25/1029 , A61F2250/0067 , A61M2025/0036 , A61M2025/004 , A61M2025/105 , A61M2025/1086 , A61M25/10 , A61M25/1027
摘要： An inflatable medical device and method for the placement of a stent in a body passageway by means of a two stage expansion of the stent and for the delivery of medications to precise location in the passageway. The device includes a catheter shaft (14) having a plurality of lumens (13, 22, 28) disposed therein. The catheter shaft has a distal end adapted to be disposed within a vascular passageway. An inflatable balloon is defined by a generally cylindrical wall and is adapted to receive inflation fluids. The balloon is disposed on the distal end of the shaft. An array of circumferentially arranged inflation conduits (40) is disposed in the wall. The conduits (40) are spaced from each other within the wall of the balloon whereby to form a annular array. An array of medication delivering conduits (25) can be disposed within the wall of the balloon. These conduits are adapted to deliver medications to predetermined locations within the body passageway being treated. A stent (30) is removably disposed around the exterior of the wall of the balloon and is expandable radially outwardly from a narrow insertion diameter to a larger second diameter by the expansion of the balloon (16) and then to a still larger third diameter by inflation of the inflation conduits (40) whereby to expand the body passageway and seat the stent.
摘要翻译： 一种可膨胀的医疗装置和方法，用于通过支架的两级膨胀以及将药物输送到通道中的精确位置来将支架放置在身体通道中。 该装置包括具有设置在其中的多个管腔（13,22,28）的导管轴（14）。 导管轴具有适于设置在血管通路内的远端。 可充气气囊由大致圆柱形的壁限定，适于接收充气流体。 气球设置在轴的远端。 周向布置的充气管道（40）的阵列设置在壁中。 导管（40）在球囊的壁内彼此间隔开，从而形成环形阵列。 一组药物输送管道（25）可以设置在气囊的壁内。 这些导管适于将药物递送至正在治疗的身体通路内的预定位置。 支架（30）可移除地设置在球囊的壁的外部周围，并且通过球囊（16）的膨胀而从狭窄的插入直径径向向外扩张到更大的第二直径，然后通过 膨胀管道（40）的膨胀，从而扩张身体通道并对支架进行安置。
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公开(公告)号：US5588962A
公开(公告)日：1996-12-31
申请号：US219108
申请日：1994-03-29
CPC分类号： A61M25/104 , A61M37/00 , A61M2025/105 , A61M2025/109
摘要： A diseased site, such as vascular dilatation site, is treated by first locally delivering to the site an agent that is effective to localize a desired drug and then systematically administering the drug.
摘要翻译： 首先将病变部位如血管扩张部位局部输送到有效定位所需药物然后系统施用该药物的药剂。
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公开(公告)号：US5464016A
公开(公告)日：1995-11-07
申请号：US355435
申请日：1994-12-13
IPC分类号： A61B8/12
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445
摘要： An ultrasound imaging device and method employing it featuring a stationary, elongated flexible tubular body, a rotatable drive shaft extending through the body, and a nose member located distally of the tubular body, the nose member mounted on the distal end of the drive shaft to rotate therewith, the nose member being of rounded atraumatic form, sized at its proximal end to substantially match the diameter of the body and an acoustic imaging transducer incorporated in the nose member for producing acoustic images of adjacent tissue as the drive shaft turns, there being an axial passage within the body for fluid flow from a proximal entry port to at least one fluid delivery port located distally of the entry port.
摘要翻译： 一种超声波成像装置和方法，其特征在于具有静止的，细长的柔性管状体，延伸穿过本体的可旋转驱动轴和位于管状体远端的鼻部构件，鼻部构件安装在驱动轴的远端上 鼻部构件为圆形无创伤形式，其大小在其近端处大体上与身体的直径相匹配;以及声学成像传感器，其结合在鼻部构件中，用于当驱动轴转动时产生相邻组织的声像， 主体内的轴向通道用于流体从近端进入口流到位于入口端口远端的至少一个流体输送口。
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