公开(公告)号：US06702781B1

公开(公告)日：2004-03-09

申请号：US08007756

申请日：1993-01-22

申请人： Nikolaus Reifart ,  Erik Andersen ,  John E. Abele ,  Sandra G. Tartaglino ,  Timothy W. Wheeler

发明人： Nikolaus Reifart ,  Erik Andersen ,  John E. Abele ,  Sandra G. Tartaglino ,  Timothy W. Wheeler

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/1079

摘要： A stiffenable balloon catheter assembly capable of being converted from an “over-the-wire” mode with respect to a guidewire extending therethrough to a “rapid-exchange” mode with respect to a guidewire extending therethrough, and vice versa. The catheter has a plurality of lumens, one lumen however, having a side opening with an obstructable galp, the orientation of which, determines the utilization “mode” of the catheter assembly. Stiffening stylets may be adjustably locked into the lumens, depending upon the “mode”, to control the stiffness of the catheter assembly during its utilization within a patient.

公开(公告)号：US06277084B1

公开(公告)日：2001-08-21

申请号：US08851163

申请日：1997-05-05

申请人： John E. Abele ,  Kevin R. Heath

发明人： John E. Abele ,  Kevin R. Heath

IPC分类号： A61B1722

CPC分类号： A61B17/22012 ,  A61B90/39 ,  A61F2002/3008 ,  A61F2002/30093 ,  A61F2210/0019 ,  A61F2240/001 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/088 ,  A61L31/18 ,  A61M25/0108 ,  A61M2025/09166 ,  Y10T29/53909

摘要： Wires are used for conducting ultrasound energy. These wires achieve optimum properties by creating a multiple material coaxial construction. For example, in a particular embodiment it is desirable to have an elastic core (nitinol) for conducting axial vibrations (sonic or ultrasonic) and a thin stiff cladding (stainless steel) in order to minimize traverse vibrations which result in loss of energy.

摘要翻译： 电线用于进行超声能量。 这些电线通过创建多材料同轴结构来实现最佳性能。 例如，在一个具体实施方案中，期望具有用于传导轴向振动（声波或超声波）和薄的硬包层（不锈钢）的弹性芯（镍钛诺），以便最小化导致能量损失的横动振动。

公开(公告)号：US6004269A

公开(公告)日：1999-12-21

申请号：US473137

申请日：1995-06-07

申请人： Robert J. Crowley ,  John E. Abele ,  Charles D. Lennox ,  Susan M. Ropiak

发明人： Robert J. Crowley ,  John E. Abele ,  Charles D. Lennox ,  Susan M. Ropiak

IPC分类号： A61B17/32 ,  A61B8/12 ,  A61B17/00 ,  A61B17/22 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61B8/00 ,  A61B5/04 ,  A61N1/06

CPC分类号： A61B8/12 ,  A61B17/2202 ,  A61B18/1492 ,  A61B8/445 ,  A61B8/4461 ,  A61B2017/00243 ,  A61B2017/00924 ,  A61B2017/22051 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00797 ,  A61B2018/00869 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/065 ,  A61B2090/378 ,  A61B2090/3782 ,  A61B8/06 ,  A61B8/543 ,  A61B90/39

摘要： An acoustic imaging system for use within a heart has a catheter (6), an ultrasound device (10) incorporated into the catheter (6), and an electrode (300, 304, 334, 394) mounted on the catheter (6). The ultrasound device (10) directs ultrasonic signals toward an internal structure in the heart to create an ultrasonic image, and the electrode (300, 304, 334, 394) is arranged for electrical contact with the internal structure. A chemical ablation device (55, 86, 314, 396) mounted on the catheter (6) ablates at least a portion of the internal structure by delivery of fluid to the internal structure. The ablation device (55) may include a material that vibrates in response to electrical excitation, the ablation being at least assisted by vibration of the material. The ablation device may alternatively be a transducer (414) incorporated into the catheter (6), arranged to convert electrical signals into radiation and to direct the radiation toward the internal structure. The electrode may be a sonolucent structure (304, 334) incorporated into the catheter (6).

摘要翻译： 在心脏内使用的声学成像系统具有导管（6），并入导管（6）中的超声装置（10）和安装在导管（6）上的电极（300,304,334,394）。 超声波装置（10）将超声信号引导到心脏内的内部结构以产生超声波图像，并且电极（300,304,334,394）被布置成与内部结构电接触。 安装在导管（6）上的化学消融装置（55,86,314,396）通过将流体输送到内部结构来消融内部结构的至少一部分。 消融装置（55）可以包括响应于电激发而振动的材料，该消融至少由材料的振动辅助。 消融装置可以替代地是结合到导管（6）中的换能器（414），其布置成将电信号转换成辐射并将辐射引向内部结构。 电极可以是结合到导管（6）中的声光结构（304,334）。

公开(公告)号：US5693014A

公开(公告)日：1997-12-02

申请号：US441603

申请日：1995-05-15

申请人： John E. Abele ,  Ronald A. Sahatjian

发明人： John E. Abele ,  Ronald A. Sahatjian

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M25/1038 ,  A61M2025/0047 ,  A61M2025/1031 ,  A61M2025/1086 ,  A61M25/0043 ,  A61M25/1029

摘要： An expansible balloon catheter has at least a first exterior surface with a given coefficient of friction and a second exterior surface with a greater coefficient of friction. In a compact form only the first exterior surface is exposed to produce a low coefficient of friction during transfer of the collapsed or uninflated balloon to and across a lesion. When inflated, the second surface dominates the first surface and produces an increased coefficient of friction overall thereby to stabilize the balloon in the lesion.

摘要翻译： 可膨胀球囊导管至少具有给定摩擦系数的第一外表面和具有更大摩擦系数的第二外表面。 在紧凑形式中，仅将第一外表面暴露以在将塌缩或未膨胀的气囊转移到病变处和穿过病变处产生低摩擦系数。 当膨胀时，第二表面支配第一表面并产生增加的摩擦系数，从而使气囊在病变中稳定。

公开(公告)号：US5151100A

公开(公告)日：1992-09-29

申请号：US547931

申请日：1990-07-03

申请人： John E. Abele ,  Charles E. Lennox ,  Paul C. Nardella ,  Sharad H. Joshi

发明人： John E. Abele ,  Charles E. Lennox ,  Paul C. Nardella ,  Sharad H. Joshi

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/04 ,  A61B18/08 ,  A61F2/958 ,  A61F7/12 ,  A61M25/00 ,  A61N5/02

CPC分类号： A61B18/08 ,  A61B18/082 ,  A61F7/123 ,  A61B17/22 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00132 ,  A61B2017/00274 ,  A61B2017/22062 ,  A61B2018/0022 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/044 ,  A61M2205/366 ,  A61M25/10

摘要： A catheter device and method for heating tissue, the device having a catheter shaft constructed for insertion into a patient's body, and at least one chamber mounted on the catheter shaft. The catheter shaft has at least one lumen for fluid flow through the shaft. The chambers are defined by walls that are at least in part expandable. Fluid flows, through the lumens, between the chambers and a fluid source outside the body. The chambers can be filled with the fluid after they have been placed within the body. A heating device heats liquid within at least one of the chambers, so that heat is transmitted from the liquid to surrounding tissue by thermal conduction through the wall of the chamber. Means are provided for selectively directing heat transmission toward a selected portion of surrounding tissue. The chambers are fillable with fluid separately from each other, so that the chambers can occupy any of a plurality of possible total volumes. By selecting the total volume of chambers, compression of the tissue can be controlled, and hence the effectiveness of transfer of heat to the tissue can be controlled. According to the method, the catheter device is used to heat tissue from within a duct in a patient's body. The chambers are inserted into the duct and filled with fluid. Liquid is heated within at least one of the chambers, and heat is selectively directed toward a selected portion of surrounding tissue.

摘要翻译： 一种用于加热组织的导管装置和方法，该装置具有构造成用于插入患者体内的导管轴以及安装在导管轴上的至少一个室。 导管轴具有至少一个流体，用于流过轴的流体。 这些室由至少部分可膨胀的壁限定。 流体在腔室之间流过腔室，在体外流过流体源。 在将腔体放置在体内之后，腔室可以填充流体。 加热装置加热至少一个室内的液体，使得热量通过室内壁的热传导从液体传递到周围组织。 提供了用于选择性地将热传递方向导向周围组织的选定部分的装置。 这些室可以彼此分开地填充流体，使得室可以占据多个可能的总体积中的任何一个。 通过选择室的总体积，可以控制组织的压缩，因此可以控制热传递到组织的有效性。 根据该方法，导管装置用于从患者体内的管道内加热组织。 这些室被插入管道并充满流体。 在至少一个室内加热液体，并且热量选择性地朝向周围组织的选定部分。

公开(公告)号：US4235244A

公开(公告)日：1980-11-25

申请号：US928702

申请日：1978-07-27

申请人： John E. Abele ,  Robert G. Brown

发明人： John E. Abele ,  Robert G. Brown

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B10/04

CPC分类号： A61B10/04 ,  A61B2010/0216

摘要： A microbiological sampling device has inner and outer catheter tubes with a specimen sampling brush within the inner catheter body. A plug of water soluble material closes a distal end of the outer catheter body to prevent contamination of the inner catheter body and the brush during introduction into an organism, as for example, when placed in the lungs. The plug can be ejected and the sampling brush extended within the lungs to enable the brush to collect uncontaminated bacteria samples which are brushed into the inner body whereupon the entire assembly can be withdrawn. The plug protects the specimen sampling brush during introduction and is readily dissolvable avoiding unwanted biological problems, yet sealing the assembly against contamination.

摘要翻译： 微生物采样装置具有内导管和外导管，在内导管体内具有标本取样刷。 水溶性物质的塞子封闭外部导管体的远端，以防止在引入生物体期间内部导管体和刷子的污染，例如当放置在肺部时。 插头可以弹出并且采样刷在肺内延伸以使得刷可以收集未被污染的细菌样品，这些细菌样品被刷到内部体内，从而可以抽出整个组件。 插头在引入期间保护样品采样刷，并且易于溶解，避免不必要的生物学问题，同时密封组件免受污染。

公开(公告)号：US06733473B1

公开(公告)日：2004-05-11

申请号：US08089655

申请日：1993-07-09

申请人： Nikolaus Reifart ,  Erik Andersen ,  John E. Abele ,  Sandra G. Tartaglino ,  Timothy W. Wheeler

发明人： Nikolaus Reifart ,  Erik Andersen ,  John E. Abele ,  Sandra G. Tartaglino ,  Timothy W. Wheeler

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/1079

摘要： A stiffenable balloon catheter assembly capable of being converted from an “over-the-wire” mode with respect to a guidewire extending therethrough to a “rapid-exchange” mode with respect to a guidewire extending therethrough, and vice versa. The catheter has a plurality of lumens, one lumen however, having a side opening with an obstructable galp, the orientation of which, determines the utilization “mode” of the catheter assembly. Stiffening stylets may be adjustably locked into the lumens, depending upon the “mode”, to control the stiffness of the catheter assembly during its utilization within a patient.

摘要翻译： 相对于延伸穿过其中的导丝线，相对于延伸穿过其的导丝线，可以从“线上”模式转换成“快速交换”模式的可加强气球导管组件，反之亦然。 导管具有多个管腔，但是，一个管腔具有一个具有阻塞性隆起的侧开口，其取向决定了导管组件的利用“模式”。 取决于“模式”，加强样式可以可调节地锁定到腔中，以在患者体内使用期间控制导管组件的刚度。

公开(公告)号：US06494881B1

公开(公告)日：2002-12-17

申请号：US08940665

申请日：1997-09-30

申请人： Thomas O. Bales ,  Michael W. Calhoun ,  Robert Sixto, Jr. ,  John E. Abele

发明人： Thomas O. Bales ,  Michael W. Calhoun ,  Robert Sixto, Jr. ,  John E. Abele

IPC分类号： A61B1818

CPC分类号： A61B18/149 ,  A61B18/042 ,  A61B2017/0088 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00136 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/1213 ,  A61B2018/126 ,  A61B2018/1417 ,  A61B2218/002 ,  A61B2218/007

摘要： An electro-surgical device for performing tissue resection and cauterization includes an elongated body, a pair of arms extending from a distal end of the elongated body, and an electrode in communication with the pair of arms. The elongated body is adapted to be coupled to a source of energy at a proximal end. The electrode has a first region coated with an insulative coating and a second region for focusing energy emission. The coating can be a diamond-like carbon coating or other coating exhibiting resistance to cracking at high temperatures and high voltages. The coating can be deposited on a base section of a loop electrode while the end sections remain free of the coating. Alternatively, the coating can be unevenly deposited on the electrode. In other embodiments, the electrode can comprise a rollerball and the insulative coating can be deposited on selected or random portions of the rollerball. The insulative coating prevents energy loss to fluid and tissue during the operation, thus allowing resection and cauterization to be efficiently performed.

摘要翻译： 用于进行组织切除和烧灼的电外科装置包括细长主体，从细长主体的远端延伸的一对臂以及与该对臂连通的电极。 细长体适于在近端耦合到能量源。 电极具有涂覆有绝缘涂层的第一区域和用于聚焦能量发射的第二区域。 涂层可以是类金刚石碳涂层或其它在高温和高电压下具有抗开裂性能的涂层。 涂层可以沉积在环形电极的基部上，而端部保持不受涂层的影响。 或者，涂层可能不均匀地沉积在电极上。 在其他实施例中，电极可以包括一个滚球，并且绝缘涂层可以沉积在滚球的选定的或随机的部分上。 绝缘涂层在操作期间防止对流体和组织的能量损失，从而允许有效地进行切除和烧灼。

公开(公告)号：US5746745A

公开(公告)日：1998-05-05

申请号：US609274

申请日：1996-03-01

申请人： John E. Abele ,  Ronald A. Sahatjian

发明人： John E. Abele ,  Ronald A. Sahatjian

IPC分类号： A61M25/00 ,  A61F2/06 ,  A61F2/84 ,  A61M25/10 ,  A61M29/02 ,  A61F11/00

CPC分类号： A61M25/104 ,  A61F2/958 ,  A61M25/1002 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/0047 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61M25/0043 ,  A61M25/1029

摘要： An expansible balloon catheter with a stent thereon has at least a first exterior surface with a given coefficient of friction and a second exterior surface with a different coefficient of friction. In a compact form only the first exterior surface is exposed to produce one coefficient of friction during transfer of the collapsed or uninflated balloon and stent to and across a lesion. When inflated, the second surface dominates the first surface and produces a second coefficient of friction.

摘要翻译： 具有支架的可膨胀球囊导管至少具有给定摩擦系数的第一外表面和具有不同摩擦系数的第二外表面。 在紧凑形式中，只有第一外表面暴露以在将塌缩或未膨胀的气囊和支架转移到病变处和穿过病变时产生一个摩擦系数。 当膨胀时，第二表面支配第一表面并产生第二摩擦系数。

公开(公告)号：US5704913A

公开(公告)日：1998-01-06

申请号：US246485

申请日：1994-05-19

申请人： John E. Abele ,  Peter M. Nicholas ,  James C. Wang

发明人： John E. Abele ,  Peter M. Nicholas ,  James C. Wang

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1075 ,  A61M2025/1086

摘要： A catheter for insertion into a bodily conduit, especially an artery. The catheter comprises a shaft (26) having at least one lumen (24) for delivery of a fluid inflation media and a double balloon (12) including an array (20) of a plurality of inflatable secondary chambers (22) radially disposed in a cylindrical array around an inflatable primary chamber (16). Each of the secondary chambers (22) shares a common wall (38) with adjacent secondary chambers (22) and a common wall (14) with the primary chamber (16). The secondary chambers (22) are inflated by an array of channels (32) which are separated from each other by webs (40). One or more of the secondary chambers (22) may be in communication with a pressure transducer for measurement of the resistance of, e.g., a stenosis to dilation by the balloon (12). Alternately, a triple balloon (60) has inner secondary chambers (22a) and outer secondary chambers (22b). Also alternately, one or more of the secondary chambers (22) may be adapted to dispense medication. A method for treating a constricted bodily conduit using the catheter is also disclosed.

摘要翻译： 用于插入身体导管，特别是动脉的导管。 导管包括具有用于输送流体膨胀介质的至少一个内腔（24）的轴（26）和包括放射状设置在多个可膨胀的第二腔室（22）中的多个可充气副腔室（22）的阵列（20）的双气囊（12） 围绕可充气主室（16）的圆柱形阵列。 每个次级室（22）与相邻的副室（22）和与主室（16）的公共壁（14）共用公共壁（38）。 二次室（22）由通过腹板（40）彼此分离的通道阵列（32）而膨胀。 二次腔室（22）中的一个或多个可以与压力换能器连通，用于测量例如由球囊（12）扩张的狭窄阻力。 或者，三重气囊（60）具有内部辅助室（22a）和外部二级室（22b）。 还可以选择地，一个或多个第二腔室（22）可适于分配药物。 还公开了一种使用导管治疗收缩的身体导管的方法。