-
公开(公告)号：US08206435B2
公开(公告)日：2012-06-26
申请号：US12390542
申请日：2009-02-23
申请人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译： 可扩张医疗装置具有连接在一起的细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。 支柱中的至少一个包括至少部分穿过支柱的厚度延伸的至少一个开口。 将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。 或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。 可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。
-
公开(公告)号：US07208010B2
公开(公告)日：2007-04-24
申请号：US09948989
申请日：2001-09-07
申请人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译： 可扩张医疗装置具有连接在一起的多个细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。 所述多个支柱中的至少一个支柱包括至少部分穿过支柱的厚度延伸的至少一个开口。 将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。 或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。 可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。
-
公开(公告)号：US20090163995A1
公开(公告)日：2009-06-25
申请号：US12390542
申请日：2009-02-23
申请人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译： 可扩张医疗装置具有连接在一起的多个细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。 所述多个支柱中的至少一个支柱包括至少部分穿过所述支柱的厚度延伸的至少一个开口。 将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。 或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。 可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。
-
公开(公告)号：US08187321B2
公开(公告)日：2012-05-29
申请号：US11222202
申请日：2005-09-07
申请人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译： 可扩张医疗装置具有连接在一起的多个细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。 所述多个支柱中的至少一个支柱包括至少部分穿过所述支柱的厚度延伸的至少一个开口。 将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。 或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。 可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。
-
公开(公告)号：US08202313B2
公开(公告)日：2012-06-19
申请号：US10849324
申请日：2004-05-19
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2250/0004 , A61F2250/0068
摘要： An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.
摘要翻译： 一种具有多个细长支柱的可扩张医疗装置，所述多个细长支柱通过延性铰链连接在一起以形成可从具有第一直径的圆柱体膨胀至具有第二直径的圆柱体的基本上圆柱形的装置。 多个支柱和延性铰链被布置成改善支柱的空间分布，这在用支柱输送有益试剂时是特别重要的。 改进的支柱布置扩展到基本上平行四边形的形状，以改善对周围组织的有益剂分布。 有益剂可以装载到支柱内的开口中或涂覆到支柱上以输送到组织。
-
公开(公告)号：US07842083B2
公开(公告)日：2010-11-30
申请号：US11363123
申请日：2006-02-27
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2250/0004 , A61F2250/0068
摘要： An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.
摘要翻译： 一种具有多个细长支柱的可扩张医疗装置，所述多个细长支柱通过延性铰链连接在一起以形成可从具有第一直径的圆柱体膨胀至具有第二直径的圆柱体的基本上圆柱形的装置。 多个支柱和延性铰链被布置成改善支柱的空间分布，这在用支柱输送有益试剂时是特别重要的。 改进的支柱布置扩展到基本上平行四边形的形状，以改善对周围组织的有益剂分布。 有益剂可以装载到支柱内的开口中或涂覆到支柱上以输送到组织。
-
公开(公告)号：US06764507B2
公开(公告)日：2004-07-20
申请号：US09948987
申请日：2001-09-07
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2250/0004 , A61F2250/0068
摘要： An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.
摘要翻译： 一种具有多个细长支柱的可扩张医疗装置，所述多个细长支柱通过延性铰链连接在一起以形成可从具有第一直径的圆柱体膨胀至具有第二直径的圆柱体的基本上圆柱形的装置。 多个支柱和延性铰链被布置成改善支柱的空间分布，这在用支柱输送有益试剂时是特别重要的。 改进的支柱布置扩展到基本上平行四边形的形状，以改善对周围组织的有益剂分布。 有益剂可以装载到支柱内的开口中或涂覆到支柱上以输送到组织。
-
公开(公告)号：US08252339B2
公开(公告)日：2012-08-28
申请号：US11732909
申请日：2007-04-05
申请人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino , Sujata K. Bhatia , Elazer R. Edelman , Tarek Michael Shazly , Michael Jordan Feldstein
发明人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino , Sujata K. Bhatia , Elazer R. Edelman , Tarek Michael Shazly , Michael Jordan Feldstein
CPC分类号： A61K9/16 , A61K9/1635 , A61K9/1652 , A61K9/1682 , A61K31/785 , A61L15/24 , A61L15/44
摘要： A method for medical treatment was developed in which microspheres with novel properties are administered in a mammal. The microspheres are made using a novel process that results in microspheres with new combined properties of high density, low fracture, high swell capacity, rapid swell, and deformability following swell. These microspheres may be administered for void filling, tissue bulking, non-vasculature occlusion, body fluid absorption, and delivery of medications.
摘要翻译： 开发了一种治疗方法，其中在哺乳动物中施用具有新特性的微球。 使用新颖的方法制备微球，其导致具有高密度，低断裂，高溶胀能力，膨胀膨胀和膨胀后的变形性的新组合性质的微球。 这些微球可以用于空隙填充，组织膨胀，非脉管闭塞，体液吸收和药物的递送。
-
公开(公告)号：US07066905B2
公开(公告)日：2006-06-27
申请号：US10293002
申请日：2002-11-13
CPC分类号： A61M25/1011 , A61M25/01 , A61M2025/1086
摘要： Embodiments of the present invention are directed to a method and apparatus for accurate positioning of a dual balloon catheter. In one embodiment of the present invention, a first balloon provides an anchoring point. In one embodiment, the first balloon has protrusions to help secure its position. In one embodiment, once the first balloon is inflated, it provides a fixed position relative to which a second balloon is accurately positioned in the treatment region. In another embodiment, a second balloon imparts a radial force. In another embodiment, a second balloon imparts an axial force, using the first balloon as an anchor against which the force is applied. The force may be applied in a forward or a backward direction. In yet another embodiment, a second balloon imparts a rotational force, using the first balloon as an anchor against which the force is applied.
摘要翻译： 本发明的实施例涉及一种用于双球囊导管的精确定位的方法和装置。 在本发明的一个实施例中，第一球囊提供锚定点。 在一个实施例中，第一气囊具有突起以帮助确保其位置。 在一个实施例中，一旦第一球囊被充气，其提供固定位置，相对于该固定位置，第二球囊被准确地定位在治疗区域中。 在另一个实施例中，第二球囊赋予径向力。 在另一个实施例中，第二球囊使用第一气球作为施加力的锚杆施加轴向力。 该力可以向前或向后施加。 在另一个实施例中，第二球囊使用第一气球作为施加力的锚杆施加旋转力。
-
公开(公告)号：US10022222B2
公开(公告)日：2018-07-17
申请号：US12899231
申请日：2010-10-06
申请人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer R. Edelman
发明人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer R. Edelman
IPC分类号： A61F2/24
摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.
-
-
-
-
-
-
-
-
-
搜索结果
46 条记录 (耗时 0.036 秒)
