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    Systems and methods for treating lumenal valves
    1.
    发明授权
    Systems and methods for treating lumenal valves 有权

    公开(公告)号：US10022222B2

    公开(公告)日：2018-07-17

    申请号：US12899231

    申请日：2010-10-06

    Applicant: Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

    Inventor： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

    IPC: A61F2/24

    Abstract: The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

    Mechanical testing system and method
    2.
    发明授权
    Mechanical testing system and method 有权
    机械试验系统及方法

    公开(公告)号：US09091617B2

    公开(公告)日：2015-07-28

    申请号：US13695343

    申请日：2011-05-31

    Applicant: Elazer R. Edelman ,  Kay Dee Furman ,  Gerard J. Desany

    Inventor： Elazer R. Edelman ,  Kay Dee Furman ,  Gerard J. Desany

    IPC: G01N3/08

    CPC classification number: G01N3/08 ,  G01N3/04 ,  G01N3/32 ,  G01N2203/0005 ,  G01N2203/0023 ,  G01N2203/0026 ,  G01N2203/0028 ,  G01N2203/0073 ,  G01N2203/0089 ,  G01N2203/0242 ,  G01N2203/0246 ,  G01N2203/0266 ,  G01N2203/0274 ,  G01N2203/0435

    Abstract: A fixture facilitates using a linear force of a uni-axial test machine to subject a test sample to bending forces. The test machine includes a frame and a crosshead. To generate the linear force, the crosshead translates with reference to the frame in a plane of motion. The fixture includes an upper connecting link, a lower connecting link, and two transverse arms. The upper connecting link is configured to attach to the crosshead for receiving the linear force, and the lower connecting link is configured to attach to the frame. The two transverse arms are pivotably carried between the upper and lower links. Each transverse arm has an inner end configured to attach to the test sample, the test sample being suspended between the arms. The transverse arms pivot in opposite directions in response to the linear force applied to the upper connecting link, exposing the sample to bending forces.

    Abstract translation: 固定装置有助于使用单轴测试机的线性力来使测试样品承受弯曲力。 试验机包括框架和十字头。 为了产生线性力，十字头在运动平面中相对于框架平移。 固定装置包括上连接连杆，下连接连杆和两横向臂。 上连接链接被配置为附接到十字头以接收线性力，并且下连接链路被配置为附接到框架。 两个横向臂可枢转地承载在上部和下部连杆之间。 每个横臂具有构造成附接到测试样品的内端，测试样品悬挂在臂之间。 横向臂响应于施加到上连接连杆的线性力而以相反的方向枢转，将样品暴露于弯曲力。

    Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair
    4.
    发明申请
    Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair 有权
    组织工程内皮和上皮植入物差异性和协同调节组织修复

    公开(公告)号：US20140099289A1

    公开(公告)日：2014-04-10

    申请号：US14098902

    申请日：2013-12-06

    Applicant: Elazer R. Edelman ,  Brett Zani

    Inventor： Elazer R. Edelman ,  Brett Zani

    IPC: A61K35/36

    CPC classification number: A61K35/36 ,  A61K35/12 ,  A61K35/42 ,  A61L27/3808 ,  C12N5/0688 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/25 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2501/81 ,  C12N2502/28 ,  C12N2533/00 ,  C12N2533/54

    Abstract: Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.

    Abstract translation: 内皮植入物在损伤后恢复血管稳态，而不会重建血管结构。 内皮细胞对血管上皮细胞和下面的vasa血管排除细胞对照之间的区别。 与血管不同，气道上皮与血管内皮细胞高度分化，区别于支气管血管，允许调查差异对照组织工程细胞可能在气道和血管中提供。 通过气道损伤和细胞培养模型，发现支气管上皮和内皮的组织工程植入物通过气道微环境的生物化学调节促进气道的协同修复。 虽然上皮细胞调节局部组织组成和反应，内皮细胞保留上皮细胞; 一起，他们的相对影响被增强，表明两种细胞类型协同作用用于气道修复。

    Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair
    6.
    发明申请
    Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair 审中-公开
    组织工程内皮和上皮植入物差异性和协同调节组织修复

    公开(公告)号：US20100239671A1

    公开(公告)日：2010-09-23

    申请号：US12738956

    申请日：2008-05-06

    Applicant: Elazer R. Edelman ,  Brett Zani

    Inventor： Elazer R. Edelman ,  Brett Zani

    IPC: A61K9/14 ,  A61K35/12 ,  A61P11/00

    CPC classification number: A61K35/36 ,  A61K35/12 ,  A61K35/42 ,  A61L27/3808 ,  C12N5/0688 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/25 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2501/81 ,  C12N2502/28 ,  C12N2533/00 ,  C12N2533/54

    Abstract: Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.

    Abstract translation: 内皮植入物在损伤后恢复血管稳态，而不会重建血管结构。 内皮细胞对血管上皮细胞和下面的vasa血管排除细胞对照之间的区别。 与血管不同，气道上皮与血管内皮细胞高度分化，区别于支气管血管，允许调查差异对照组织工程细胞可能在气道和血管中提供。 通过气道损伤和细胞培养模型，发现支气管上皮和内皮的组织工程植入物通过气道微环境的生物化学调节促进气道的协同修复。 虽然上皮细胞调节局部组织组成和反应，内皮细胞保留上皮细胞; 一起，他们的相对影响被增强，表明两种细胞类型协同作用用于气道修复。

    Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases
    7.
    发明申请
    Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases 审中-公开
    治疗和治疗血管生成介导的疾病的材料和方法

    公开(公告)号：US20100092532A1

    公开(公告)日：2010-04-15

    申请号：US12513564

    申请日：2007-11-07

    Applicant: Helen Marie Nugent ,  Elazer R. Edelman ,  Robert M. Tjin Tham Sjin ,  Yin Shan Ng

    Inventor： Helen Marie Nugent ,  Elazer R. Edelman ,  Robert M. Tjin Tham Sjin ,  Yin Shan Ng

    IPC: A61K9/00 ,  A61K35/12 ,  A61P9/00

    CPC classification number: A61K35/36 ,  A61K35/44 ,  A61L31/005

    Abstract: Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy.

    Abstract translation: 本文公开了适用于治疗病理性血管生成和异常新血管形成的部位的材料和方法。 病理性血管生成或异常新血管形成的部位可以通过将病理性血管发生或异常新生血管形成区域附近的表面与可植入材料接触来处理。 可植入材料包括生物相容性基质和细胞，并且具有有效治疗受影响部位的量。 组合物可以是柔性平面材料或可流动组合物。 用本发明治疗的疾病包括例如黄斑变性，类风湿性关节炎，牛皮癣，银屑病关节炎，全身性炎症性疾病，以及通过手术切除，放射治疗或化疗治疗肿瘤。

    Stent expansion and apposition sensing
    8.
    发明授权
    Stent expansion and apposition sensing 失效
    支架扩张和并置感应

    公开(公告)号：US06179858B2

    公开(公告)日：2001-01-30

    申请号：US09227555

    申请日：1999-01-08

    Applicant: James C. Squire ,  Campell Rogers ,  Elazer R. Edelman

    Inventor： James C. Squire ,  Campell Rogers ,  Elazer R. Edelman

    IPC: A61B1700

    CPC classification number: A61F2/958 ,  A61M2025/0002

    Abstract: An apposition sensing system including a stent; a catheter assembly to which the stent is coupled for deployment into a lumen; and a sensor positioned on the catheter assembly adjacent to an end of the stent. The sensor is adapted to provide an electrical parameter which is indicative of apposition of the end of the stent to the inner wall of the lumen. In one aspect of the invention, the sensor includes first and second pressure sensors positioned at proximal and distal portions of the catheter assembly adjacent to proximal and distal ends of the stent. A monitoring unit monitors pressure changes sensed by the sensors. In accordance with an alternative embodiment of the invention, there is provided an expansion sensing system including a stent having an electrically conductive region; an expandable insulating sleeve; a catheter assembly to which the stent is coupled for deployment into a lumen; and at least one electrode associated with the catheter assembly. The sleeve is positioned between the electrode and the conductive region, the electrode and conductive region being adapted to provide an electrical parameter which varies in correspondence with expansion of the stent. In one aspect of the invention, the sleeve positioned between the electrode and the conductive region define a variable capacitor. A monitoring unit monitors variations in capacitance between the electrode and conductive region which is directly proportional to the change in stent diameter.

    Abstract translation: 包括支架的安置感测系统; 导管组件，所述支架联接到所述导管组件以展开到内腔中; 以及位于导管组件上邻近支架端部的传感器。 传感器适于提供电参数，其指示支架的端部与内腔的内壁的并置。 在本发明的一个方面，传感器包括位于导管组件的邻近支架的近端和远端的近端部分和远端部分的第一和第二压力传感器。 监控单元监视传感器感测到的压力变化。 根据本发明的替代实施例，提供了一种包括具有导电区域的支架的膨胀感测系统; 可膨胀绝缘套管; 导管组件，所述支架联接到所述导管组件以展开到内腔中; 以及与导管组件相关联的至少一个电极。 套筒位于电极和导电区域之间，电极和导电区域适于提供根据支架膨胀而变化的电参数。 在本发明的一个方面，位于电极和导电区域之间的套筒限定可变电容器。 监测单元监测电极和导电区域之间的电容变化，其与支架直径的变化成正比。

    Stent slip sensing system and method
    9.
    发明授权
    Stent slip sensing system and method 失效
    支架滑移检测系统及方法

    公开(公告)号：US6091980A

    公开(公告)日：2000-07-18

    申请号：US225282

    申请日：1999-01-05

    Applicant: James C. Squire ,  Campbell Rogers ,  Elazer R. Edelman

    Inventor： James C. Squire ,  Campbell Rogers ,  Elazer R. Edelman

    IPC: A61F2/06 ,  A61F2/84 ,  A61M25/12 ,  A61F11/00

    CPC classification number: A61F2/958

    Abstract: An endoluminal device slippage sensor system including an electrically conductive endoluminal device and a catheter assembly to which the device is coupled for deployment into a lumen. First, second and third electrodes are associated with the catheter assembly, each respectively in direct electrical contact with a proximal, a middle and a distal portion of the device. A potential source generates a potential between the first and second electrodes and between the second and third electrodes. The potential between the electrodes is varied in accordance with a change of position of the device along the axis of the catheter assembly during deployment in which the proximal or distal portion of the device is disconnected from the first or third electrode, respectively. In accordance with another embodiment of the invention there is provided an endoluminal device slippage sensor system including an electrically conductive endoluminal device and a catheter assembly to which the device is coupled for deployment into a lumen. At least two electrodes are mounted longitudinally along the length of the catheter assembly, each of the electrodes being in direct electrical contact with the device. A potential source generates a potential between the electrodes, the potential between the electrodes being varied in accordance with a change of position of the device along the axis of the catheter assembly.

    Abstract translation: 包括导电腔内装置和导管组件的腔内装置滑动传感器系统，所述装置与所述导管组件联接以将其部署到管腔中。 首先，第二和第三电极与导管组件相关联，每个分别与装置的近端，中间和远端部分直接电接触。 电位源在第一和第二电极之间以及第二和第三电极之间产生电位。 电极之间的电势根据装置沿着导管组件的轴线在展开期间的位置的变化而变化，其中装置的近侧或远端部分别与第一或第三电极分离。 根据本发明的另一个实施例，提供了一种腔内装置滑动传感器系统，其包括导电腔内装置和导管组件，该装置连接到导管组件以部署到内腔中。 至少两个电极沿导管组件的长度纵向安装，每个电极与装置直接电接触。 电位源在电极之间产生电位，电极之间的电位根据器件沿着导管组件的轴线的位置变化而变化。

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