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1.发明申请Inducing cellular immune responses to p53 using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对p53的细胞免疫应答公开(公告)号：US20050196403A1
公开(公告)日：2005-09-08
申请号：US11051411
申请日：2005-02-07
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , C07K14/4746
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare p53 epitopes, and to develop epitope-based vaccines directed towards p53-bearing tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备p53表位的机制的知识，并开发针对p53携带肿瘤的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗癌症。
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2.发明申请Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导前列腺癌抗原的细胞免疫应答公开(公告)号：US20070020327A1
公开(公告)日：2007-01-25
申请号：US11418504
申请日：2006-05-05
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
IPC分类号： A61K39/395 , A61K35/14 , A61K9/127
CPC分类号： C12Y304/17021 , A61K38/00 , A61K38/4813 , C07K14/4748
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare prostate cancer-associated antigen epitopes, and to develop epitope-based vaccines directed towards prostate tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备前列腺癌相关抗原表位的机制的知识，并开发针对前列腺肿瘤的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗癌症。
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3.发明申请HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20070098776A1
公开(公告)日：2007-05-03
申请号：US11482832
申请日：2006-07-10
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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4.发明申请Hla-a1,-a2,-a3,-a24,-b7, and-b44 tumor associated antigen peptides and compositions 审中-公开Hla-a1，-a2，-a3，-a24，-b7和-b44肿瘤相关抗原肽和组合物公开(公告)号：US20060094649A1
公开(公告)日：2006-05-04
申请号：US10538066
申请日：2003-12-10
申请人： Elissa Keogh , Scott Southwood , John Fikes , Alessandro Sette
发明人： Elissa Keogh , Scott Southwood , John Fikes , Alessandro Sette
CPC分类号： C07K14/4746 , A61K38/00 , C07K14/4748 , C07K14/70503 , C07K14/71
摘要： A peptide or composition comprising at least one epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译： 包含至少一种来自CEA，HER2 / neu，MAGE2，MAGE3或p53的表位或类似物的肽或组合物。
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公开(公告)号：US20060018915A1
公开(公告)日：2006-01-26
申请号：US10510101
申请日：2003-04-07
申请人： Glenn Ishioka , John Fikes , Shabnam Tangri , Alessandro Sette
发明人： Glenn Ishioka , John Fikes , Shabnam Tangri , Alessandro Sette
CPC分类号： C07K14/70539 , C07K14/4748 , C07K14/70503
摘要： Heteroclitic analogs of class I epitopes are prepared by providing conservative, semi-conservative, or non-conservative amino acid substitutions at positions 3 and/or 4 and/or 5 and/or 6 and/or 7 and/or 8 and/or 9 and/or 10 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wild-type epitopes.
摘要翻译： 通过在位置3和/或4和/或5和/或6和/或7和/或8和/或9上提供保守的，半保守的或非保守的氨基酸取代来制备I类表位的异位类似物 和/或这些表位中的10个。 类似物可用于相对于相应的野生型表位引起免疫应答。
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