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1.发明申请Inducing cellular immune responses to p53 using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对p53的细胞免疫应答公开(公告)号：US20050196403A1
公开(公告)日：2005-09-08
申请号：US11051411
申请日：2005-02-07
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , C07K14/4746
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare p53 epitopes, and to develop epitope-based vaccines directed towards p53-bearing tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备p53表位的机制的知识，并开发针对p53携带肿瘤的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗癌症。
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2.发明申请Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导前列腺癌抗原的细胞免疫应答公开(公告)号：US20070020327A1
公开(公告)日：2007-01-25
申请号：US11418504
申请日：2006-05-05
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
IPC分类号： A61K39/395 , A61K35/14 , A61K9/127
CPC分类号： C12Y304/17021 , A61K38/00 , A61K38/4813 , C07K14/4748
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare prostate cancer-associated antigen epitopes, and to develop epitope-based vaccines directed towards prostate tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备前列腺癌相关抗原表位的机制的知识，并开发针对前列腺肿瘤的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗癌症。
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3.发明申请HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20070098776A1
公开(公告)日：2007-05-03
申请号：US11482832
申请日：2006-07-10
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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4.发明申请Hla-a1,-a2,-a3,-a24,-b7, and-b44 tumor associated antigen peptides and compositions 审中-公开Hla-a1，-a2，-a3，-a24，-b7和-b44肿瘤相关抗原肽和组合物公开(公告)号：US20060094649A1
公开(公告)日：2006-05-04
申请号：US10538066
申请日：2003-12-10
申请人： Elissa Keogh , Scott Southwood , John Fikes , Alessandro Sette
发明人： Elissa Keogh , Scott Southwood , John Fikes , Alessandro Sette
CPC分类号： C07K14/4746 , A61K38/00 , C07K14/4748 , C07K14/70503 , C07K14/71
摘要： A peptide or composition comprising at least one epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译： 包含至少一种来自CEA，HER2 / neu，MAGE2，MAGE3或p53的表位或类似物的肽或组合物。
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5.发明授权Antibodies against human respiratory syncytial virus (RSV) and methods of use 有权针对人呼吸道合胞病毒（RSV）的抗体及其使用方法公开(公告)号：US08568719B2
公开(公告)日：2013-10-29
申请号：US12806498
申请日：2010-08-13
IPC分类号： A61K39/395
CPC分类号： C07K16/1027 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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6.发明授权Anti-human respiratory syncytial virus (RSV) antibodies and methods of use 有权抗人呼吸道合胞病毒（RSV）抗体及其使用方法公开(公告)号：US09139642B2
公开(公告)日：2015-09-22
申请号：US13809397
申请日：2011-07-08
IPC分类号： A61K39/12 , A61K39/155 , C12N7/00 , C07K16/10 , A61K31/7056 , A61K39/42 , C07K16/46 , G01N33/569 , A61K39/00
CPC分类号： C07K16/1027 , A61K31/7056 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/10 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2760/18534 , C12N2760/18571 , G01N33/56983 , G01N2333/135
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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7.发明申请公开(公告)号：US20130177573A1
公开(公告)日：2013-07-11
申请号：US13809397
申请日：2011-07-08
IPC分类号： C07K16/10
CPC分类号： C07K16/1027 , A61K31/7056 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/10 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2760/18534 , C12N2760/18571 , G01N33/56983 , G01N2333/135
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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