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1.发明申请Methods and Systems for Treatment of Neurological Diseases of the Central Nervous System 审中-公开中枢神经系统神经疾病治疗方法与系统公开(公告)号：US20110213328A1
公开(公告)日：2011-09-01
申请号：US13104938
申请日：2011-05-10
IPC分类号： A61M25/00
CPC分类号： A61K38/1709
摘要： The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.
摘要翻译： 本发明涉及用于治疗在中枢神经系统的细胞内引起活性酶或蛋白质缺乏的先天遗传错误或其他缺陷的方法和系统。 这样的方法和系统通常包括可植入导管系统，其被设计用于将特殊配制的蛋白质慢性递送至中枢神经系统的鞘内，脑室内和/或实质内区域。 本发明适用于广泛类型的溶酶体贮积病的神经病学方面。 这些基于遗传的疾病是由于酶活性不足而导致特定物质分解代谢的结果，从而在细胞溶酶体中积累。
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公开(公告)号：US5716532A
公开(公告)日：1998-02-10
申请号：US661387
申请日：1996-06-11
CPC分类号： H01G4/012 , H01G13/06 , H01G4/30 , Y10T29/417
摘要： A method of improving the breakdown strength of polymer multi-layer (PML) capacitors is provided. The method comprises removing metal, specifically, aluminum, from the cut edge. This is done by either etching back the metal electrode layers in either basic or acidic solution or by anodizing the metal to cover that portion of the metal at the edge with an oxide. Removing the metal from the cut edge increases the breakdown strength of the PML capacitors by a factor of two or more.
摘要翻译： 提供了一种提高聚合物多层（PML）电容器的击穿强度的方法。 该方法包括从切割边缘去除金属，特别是铝。 这是通过在碱性或酸性溶液中蚀刻金属电极层或通过阳极氧化金属来覆盖边缘处的金属部分以用氧化物来完成的。 从切割边缘去除金属会使PML电容器的击穿强度提高2倍以上。
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3.发明授权Apparatus for delivering single and multiple cardioversion and defibrillation pulses 失效用于输送单个和多个心脏复律和除颤脉冲的装置
公开(公告)号：US5163427A
公开(公告)日：1992-11-17
申请号：US612758
申请日：1990-11-14
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3622
摘要： An implantable cardioverter having circuitry for generating high energy cardioversion and defibrillation pulses. The output circuitry is so configured that it may provide simultaneous pulse, multiple electrode; sequential pulse, multiple electrode; or single pulse, two electrode defibrillation and/or cardioversion pulse regimens. The output circuitry is configured to allow delivery of energy sequentially from two capacitor banks during sequential pulse regimens and to deliver the energy stored in both capacitor banks simultaneously during simultaneous pulse, multiple electrode and single pulse, two electrode defibrillation pulse regimens.
摘要翻译： 具有用于产生高能量心脏复律和除颤脉冲的电路的可植入式心律转复器。 输出电路被配置成可以提供同时的脉冲，多个电极; 顺序脉冲，多电极; 或单脉冲，两电极除颤和/或心脏复律脉冲方案。 输出电路被配置为允许在顺序脉冲方案期间从两个电容器组顺序地递送能量，并且在同时脉冲，多个电极和单个脉冲，两个电极除颤脉冲方案期间同时传送存储在两个电容器组中的能量。
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公开(公告)号：US08500720B2
公开(公告)日：2013-08-06
申请号：US11124984
申请日：2005-05-09
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61K38/47 , A61K31/713 , A61K38/00 , A61M5/14276 , A61M5/172 , A61M39/0208 , A61M39/04 , A61M2210/125
摘要： The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
摘要翻译： 本发明涉及用于递送心脏病症治疗的系统和方法，其中所述系统包含用于提供含有另外缺乏患有心脏病症的患者的心脏细胞的蛋白质的蛋白质制剂的来源，以及具有 近端和远端，用于将蛋白质制剂递送到人心脏的心包囊区域。
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公开(公告)号：US20090240194A1
公开(公告)日：2009-09-24
申请号：US12476893
申请日：2009-06-02
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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公开(公告)号：US07558629B2
公开(公告)日：2009-07-07
申请号：US11414500
申请日：2006-04-28
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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公开(公告)号：US06666821B2
公开(公告)日：2003-12-23
申请号：US10040827
申请日：2002-01-08
申请人： John G. Keimel
发明人： John G. Keimel
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0031 , A61M5/14276 , A61M2205/3523 , A61M2230/201
摘要： An improved implantable sensor system is disclosed that includes an array of sensors. Each of the sensors is associated with a protective member that prevents the sensor from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor to begin sensing signals within a living body. In one embodiment, the protective member is formed of a conductive material that can oxidize, is biocompatible, bio-absorbable, and that may be dissolved in solution such as blood upon application of an electric potential. In another embodiment, the protective member is formed of a dissolvable member that dissolves within the body over a predetermined time period.
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公开(公告)号：US6091986A
公开(公告)日：2000-07-18
申请号：US67159
申请日：1998-04-27
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61N1/3702 , A61N1/365
摘要： An alternative mechanism in an implantable device for meeting the physician's need for a stored electrogram and/or other stored physiologic signal associated with a detected arrhythmic or other physiological event without the undesirable current drain associated with continuous operation of a sense amplifier and a looping memory. The device regularly but intermittently activates a sense amplifier or other sensor and associated memory circuitry, independent of detection of arrhythmias. The device may temporarily store only a single record, replacing it with new records as they are stored, or may store multiple records, replacing the oldest stored record with the newest stored record. On detection of an arrhythmia or other defined physiological event, the device may simply transfer the one or more temporarily stored electrogram strips to permanent storage, for later use by the physician in diagnosing the condition of the patient prior to detection of the event.
摘要翻译： 可植入装置中的替代机制，用于满足医生对与检测到的心律不齐或其他生理事件相关联的存储的电描记图和/或其他存储的生理信号的需要，而不需要与感测放大器和循环存储器的连续操作相关联的不期望的电流消耗。 器件定期但间断地激活读出放大器或其他传感器和相关联的存储器电路，与心律失常的检测无关。 设备可以临时存储单个记录，在存储新记录时将其替换，或者可以存储多个记录，将最旧存储的记录替换为最新存储的记录。 在检测到心律失常或其他定义的生理事件时，该装置可以简单地将一个或多个临时存储的电描记图带传送到永久性存储器，以供医生在检测到事件之前诊断患者的状况。
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公开(公告)号：US5188105A
公开(公告)日：1993-02-23
申请号：US612761
申请日：1990-11-14
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61N1/3621 , A61N1/3962 , A61N1/3987
摘要： An implantable cardioverter/defibrillator capable of detecting fibrillation and other tachyarrhythmias and of generating high energy cardioversion and defibrillation pulses. The device delivers cardioversion pulses and defibrillation pulses synchronized to heart rhythm, wherever possible. Delivery of cardioversion pulses requires verification of the continuing presence of a tachyarrhythmia, following charge up of the output capacitor in the pulse generator. In the event that cardioversion therapy is aborted, the charge on the capacitor is retained until subsequent detection of termination of the tachyarrthythmia. Defibrillation pulses are delivered synchronized to heart rhythm, wherever possible, but are delivered asynchronously if synchronization is not possible. Following delivery of a cardioversion or defibrillation pulse, the charge remaining on the capacitor is retained until detection of tachyarrhythmia or fibrillation termination, respectively.
摘要翻译： 一种能够检测原纤维性颤动和其他快速性心律失常并产生高能量心脏复律和除颤脉冲的植入式心律转复除颤器。 该设备尽可能地提供与心脏节律同步的心脏复律脉冲和除颤脉冲。 在脉冲发生器中输出电容器充电之后，输出心脏复律脉冲需要验证是否存在快速性心律失常。 在心脏复律治疗中止的情况下，电容器上的电荷被保留直到随后检测到快速性心律失常的终止。 除颤脉冲在可能的情况下与心律同步传送，但如果不能同步，则异步传送。 在输送复律或除颤脉冲之后，保留在电容器上的电荷分别保持直到检测到快速性心律失常或颤动终止。
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公开(公告)号：US4515160A
公开(公告)日：1985-05-07
申请号：US371335
申请日：1982-04-23
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61N1/37252 , A61N1/37211
摘要： The programming of pulse intervals and the inhibition of the output of an implanted cardiac pacemaker are disclosed. The occurence of either an output pulse from the implanted unit or of cardiac activity allows for synchronization of the programming unit with the implanted device so the external programmer can control the pulse timing sequence of the implanted unit. The implanted unit can be programmed after each pulse, or as required, to obtain a pulse sequence which may be used to provoke, or terminate, tachyarrhythmics thus enabling non-invasive electrophysiologic studies, or therapeutic stimulation.
摘要翻译： 公开了脉冲间隔的编程和植入的心脏起搏器输出的抑制。 来自植入单元的输出脉冲或心脏活动的发生允许编程单元与植入装置的同步，使得外部编程器可以控制植入单元的脉冲定时序列。 可以在每个脉冲之后或根据需要对植入的单元进行编程，以获得脉冲序列，其可用于引发或终止快速心律，从而实现非侵入性电生理学研究或治疗性刺激。
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