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公开(公告)号：US09937344B2
公开(公告)日：2018-04-10
申请号：US12887149
申请日：2010-09-21
申请人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
发明人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In one example, the disclosure relates to a method including delivering a series of pulses with alternating pulse polarities to a gastrointestinal tract of a patient. The series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, and a third pulse of the first polarity, where the first, second and third pulses are delivered in direct succession and in that order. The first and second pulses are separated by a first time delay and the second and third pulses are separated by a second time delay. In some examples, each of the first and second time delays depend on the frequency that the series of pulses are delivered.
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公开(公告)号：US08301265B2
公开(公告)日：2012-10-30
申请号：US11852766
申请日：2007-09-10
申请人： Warren L. Starkebaum
发明人： Warren L. Starkebaum
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0502 , A61N1/0509 , A61N1/0558 , A61N1/36007 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： The invention is directed toward stimulation of a selected tissue layer. A device is attached to a target tissue by applying vacuum pressure to a vacuum cavity of the device and advancing a needle into tissue within the vacuum cavity. The depth on the vacuum cavity is selected to permit deployment at the selected tissue layer. In one embodiment, the invention is directed toward an implantable medical device comprising a device housing defining a vacuum cavity, and a vacuum port for application of vacuum pressure to draw tissue into the vacuum cavity, an electrode that is movable into the vacuum cavity of the device housing to contact at least a portion of the tissue drawn into the vacuum cavity, and a lead comprising at least one conductor coupled to the electrode.
摘要翻译： 本发明涉及刺激所选择的组织层。 通过将真空压力施加到装置的真空腔并将针推进到真空腔内的组织中，将装置附接到目标组织。 选择真空腔上的深度以允许在选定的组织层处展开。 在一个实施例中，本发明涉及可植入医疗装置，其包括限定真空腔的装置壳体和用于施加真空压力以将组织拉入真空腔的真空端口，可移动到真空腔的真空腔中的电极 装置外壳以接触被抽吸到真空腔中的组织的至少一部分，以及包括至少一个连接到电极的导体的引线。
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公开(公告)号：US20100228349A1
公开(公告)日：2010-09-09
申请号：US12785076
申请日：2010-05-21
申请人： Warren L. Starkebaum
发明人： Warren L. Starkebaum
IPC分类号： A61F2/08
CPC分类号： A61B17/12
摘要： A method for treatment of obesity involves implantation of bulking devices within the upper esophageal sphincter (UES) to inhibit swallowing, thereby limiting food intake and treating obesity. One or more bulking devices are implanted within or near the UES to create a partial obstruction, partially impair UES muscle function, or both. The bulking devices make swallowing difficult, limiting the rate of food intake by a patient, and discouraging the patient from quickly consuming an excessive amount of food at one time.
摘要翻译： 用于治疗肥胖症的方法包括在上食管括约肌（UES）内植入膨胀装置以抑制吞咽，从而限制食物摄取和治疗肥胖。 在UES内或附近植入一个或多个膨胀装置以产生部分阻塞，部分损害UES肌肉功能或两者。 膨胀装置使吞食困难，限制了患者的食物摄取速率，并且阻止患者一次快速消耗过量的食物。
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公开(公告)号：US07585271B2
公开(公告)日：2009-09-08
申请号：US10698131
申请日：2003-11-01
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06109 , A61B17/3478 , A61B90/39 , A61B2017/00805 , A61B2017/00898 , A61B2017/306 , A61F2/0036 , A61L31/145
摘要： In general, the invention is directed to treatment of urinary incontinence by the implantation of one or more bulking prostheses proximate to a urethral sphincter. These bulking prostheses, which may include biocompatible hydrogel, are implanted into the tissue outside the urethra, proximate to a urethral sphincter. When implanted, the bulking prostheses are in a miniature state. Upon introduction into the body, the devices enter an enlarged state. In their enlarged state, the bulking prostheses supply extra bulk to the tissues proximate to the external urethral sphincter. With the extra bulk, the patient can exercise voluntary control over the external urethral sphincter to close or maintain closure of the urethra and maintain urinary continence.
摘要翻译： 通常，本发明涉及通过植入靠近尿道括约肌的一个或多个膨胀假体来治疗尿失禁。 这些可能包括生物相容性水凝胶的膨胀假体植入尿道外侧的组织中，靠近尿道括约肌。 当植入时，膨胀假体处于微型状态。 引入身体后，设备进入放大状态。 在扩大的状态下，膨胀假体对靠近外部尿道括约肌的组织提供额外的体积。 随着额外的体积，患者可以对外部尿道括约肌进行自愿控制，以关闭或保持尿道闭合并维持尿路。
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公开(公告)号：US07141016B2
公开(公告)日：2006-11-28
申请号：US10423594
申请日：2003-04-25
IPC分类号： A61B5/00
CPC分类号： A61B5/14539 , A61B5/062 , A61B5/07 , A61B5/14532 , A61B5/4238
摘要： In general, the invention is directed to systems and methods for monitoring the gastrointestinal system of a patient. In one embodiment, the invention includes techniques for monitoring the emptying of the patient's stomach. The techniques may employ glucose monitoring, pH monitoring with a consumable sensor, of monitoring the position of a consumable sensor as it exits the stomach. Consumable sensors may be employed to sense conditions, such as temperature or bile concentration, in other segments of the gastrointestinal system. The invention also includes systems for tracking the position of one or more consumable sensors as the sensors transit the gastrointestinal system, and monitoring the conditions sensed by the sensors.
摘要翻译： 通常，本发明涉及用于监测患者的胃肠系统的系统和方法。 在一个实施例中，本发明包括用于监测患者胃排空的技术。 这些技术可以采用葡萄糖监测，用可消耗传感器进行pH监测，监测消耗型传感器在离开胃时的位置。 可以使用消耗性传感器来检测胃肠系统的其它部分中的条件，例如温度或胆汁浓度。 本发明还包括用于跟踪一个或多个消耗性传感器的位置的系统，因为传感器传送胃肠系统，并监测传感器感测到的状况。
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6.发明申请公开(公告)号：US20100228313A1
公开(公告)日：2010-09-09
申请号：US12715993
申请日：2010-03-02
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61N1/36007
摘要： The disclosure is directed to techniques for delivering electrical stimulation therapy to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.
摘要翻译： 本公开涉及用于递送电刺激治疗以支持肥胖症管理的技术。 电刺激治疗被配置为引起至少部分胃膨胀。 胃膨胀往往会引起丰满感，从而阻止患者摄取过量食物。 电刺激治疗可以通过由耦合到电刺激器的一个或多个可植入引线部署的电极递送到患者的胃肠道。 电刺激器传送刺激脉冲，其脉冲宽度在发现有效引起胃膨胀的范围内。
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公开(公告)号：US20090240194A1
公开(公告)日：2009-09-24
申请号：US12476893
申请日：2009-06-02
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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公开(公告)号：US07558629B2
公开(公告)日：2009-07-07
申请号：US11414500
申请日：2006-04-28
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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公开(公告)号：US20090069803A1
公开(公告)日：2009-03-12
申请号：US11852766
申请日：2007-09-10
申请人： Warren L. Starkebaum
发明人： Warren L. Starkebaum
IPC分类号： A61B18/14
CPC分类号： A61N1/0551 , A61N1/0502 , A61N1/0509 , A61N1/0558 , A61N1/36007 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： The invention is directed toward stimulation of a selected tissue layer. A device is attached to a target tissue by applying vacuum pressure to a vacuum cavity of the device and advancing a needle into tissue within the vacuum cavity. The depth on the vacuum cavity is selected to permit deployment at the selected tissue layer. In one embodiment, the invention is directed toward an implantable medical device comprising a device housing defining a vacuum cavity, and a vacuum port for application of vacuum pressure to draw tissue into the vacuum cavity, an electrode that is movable into the vacuum cavity of the device housing to contact at least a portion of the tissue drawn into the vacuum cavity, and a lead comprising at least one conductor coupled to the electrode.
摘要翻译： 本发明涉及刺激所选择的组织层。 通过将真空压力施加到装置的真空腔并将针推进到真空腔内的组织中，将装置附接到目标组织。 选择真空腔上的深度以允许在选定的组织层处展开。 在一个实施例中，本发明涉及可植入医疗装置，其包括限定真空腔的装置壳体和用于施加真空压力以将组织拉入真空腔的真空端口，可移动到真空腔的真空腔中的电极 装置外壳以接触抽吸到真空腔中的组织的至少一部分，以及引线，包括耦合到电极的至少一个导体。
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公开(公告)号：US07381180B2
公开(公告)日：2008-06-03
申请号：US10698216
申请日：2003-10-31
IPC分类号： A61F2/02
CPC分类号： A61F2/0036 , A61L31/145
摘要： In general, the invention is directed to treatment of fecal incontinence by the implantation of one or more bulking prostheses proximate to an anal sphincter. These bulking prostheses, which may include biocompatible hydrogel, are inserted into the tissue near the anus through a small opening in the mucosa. When inserted, the bulking prostheses are in a miniature state. Upon introduction into the body, the devices enter an enlarged state. In their enlarged state, the bulking prostheses supply extra bulk to the tissues proximate to the anal sphincters. With the extra bulk, the patient can exercise voluntary control over the external sphincter to close the anus and maintain fecal continence.
摘要翻译： 通常，本发明涉及通过植入靠近肛门括约肌的一个或多个膨胀假体来治疗大便失禁。 这些膨胀假体可以包括生物相容的水凝胶，通过粘膜中的小开口插入到肛门附近的组织中。 当插入时，膨胀假体处于微型状态。 引入身体后，设备进入放大状态。 在扩大的状态下，膨胀假体向靠近肛门括约肌的组织提供额外的体积。 随着额外的体积，患者可以对外括约肌进行自愿控制以闭合肛门并维持粪便的排列。
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