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1.发明申请Methods and Systems for Treatment of Neurological Diseases of the Central Nervous System 审中-公开中枢神经系统神经疾病治疗方法与系统公开(公告)号：US20110213328A1
公开(公告)日：2011-09-01
申请号：US13104938
申请日：2011-05-10
IPC分类号： A61M25/00
CPC分类号： A61K38/1709
摘要： The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.
摘要翻译： 本发明涉及用于治疗在中枢神经系统的细胞内引起活性酶或蛋白质缺乏的先天遗传错误或其他缺陷的方法和系统。 这样的方法和系统通常包括可植入导管系统，其被设计用于将特殊配制的蛋白质慢性递送至中枢神经系统的鞘内，脑室内和/或实质内区域。 本发明适用于广泛类型的溶酶体贮积病的神经病学方面。 这些基于遗传的疾病是由于酶活性不足而导致特定物质分解代谢的结果，从而在细胞溶酶体中积累。
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公开(公告)号：US20080140056A1
公开(公告)日：2008-06-12
申请号：US11951778
申请日：2007-12-06
IPC分类号： A61M37/00
CPC分类号： A61M27/006 , A61M25/0102 , A61M25/0108 , A61M2025/0059 , A61M2025/0063 , A61M2025/0293
摘要： A method for delivering a large molecule to the brain includes administering the large molecule via an intermittent bolus regimen intrathecally to a subject at a level of C3 or above. A method for delivering a large molecule to the brain includes rostrally advancing a catheter in the intrathecal space of a subject until a delivery region of the catheter is located at a level of C3 or above and delivering the large molecule via the delivery region. Employing aspects of such methods, a method for altering eating behavior is described.
摘要翻译： 将大分子递送到脑的方法包括通过间歇性推注方案，以C3或更高水平鞘内施用大分子给受试者。 将大分子递送到大脑的方法包括在导管的鞘内空间中螺旋地推进导管，直到导管的输送区域位于C3或更高的水平并且经由递送区域输送大分子。 采用这些方法的方面，描述了改变饮食行为的方法。
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公开(公告)号：US20080140048A1
公开(公告)日：2008-06-12
申请号：US11951755
申请日：2007-12-06
IPC分类号： A61M31/00
CPC分类号： A61M27/006 , A61M25/0102 , A61M25/0108 , A61M2025/0059 , A61M2025/0063 , A61M2025/0293
摘要： Methods for delivering first and second fluid compositions to a target location of a subject include delivering the first composition from reservoir of an implantable infusion pump and delivering the second composition through a catheter access port of the implantable infusion device. The access port and reservoir are fluidly coupled to a catheter having a delivery region implanted in the target region. The methods more fully realize the therapeutic potential of infusion devices having both an access port and a reservoir. Strategic use of different agents that compliment the function of each other delivered via either the access port or the reservoir can result in enhanced therapeutic potential.
摘要翻译： 将第一和第二流体组合物递送到受试者的目标位置的方法包括从可植入输注泵的储存器输送第一组合物并且通过可植入输注装置的导管进入口输送第二组合物。 进入口和储存器流体地联接到具有植入目标区域中的输送区域的导管。 所述方法更充分地实现具有进入口和储存器的输注装置的治疗潜力。 不同代理人的战略使用，通过访问端口或储存库交付的功能，可以提高治疗潜力。
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公开(公告)号：US08419710B2
公开(公告)日：2013-04-16
申请号：US11951755
申请日：2007-12-06
CPC分类号： A61M27/006 , A61M25/0102 , A61M25/0108 , A61M2025/0059 , A61M2025/0063 , A61M2025/0293
摘要： Methods for delivering first and second fluid compositions to a target location of a subject include delivering the first composition from reservoir of an implantable infusion pump and delivering the second composition through a catheter access port of the implantable infusion device. The access port and reservoir are fluidly coupled to a catheter having a delivery region implanted in the target region. The methods more fully realize the therapeutic potential of infusion devices having both an access port and a reservoir. Strategic use of different agents that compliment the function of each other delivered via either the access port or the reservoir can result in enhanced therapeutic potential.
摘要翻译： 将第一和第二流体组合物递送到受试者的目标位置的方法包括从可植入输注泵的储存器输送第一组合物并且通过可植入输注装置的导管进入口输送第二组合物。 进入口和储存器流体地联接到具有植入目标区域中的输送区域的导管。 所述方法更充分地实现具有进入口和储存器的输注装置的治疗潜力。 不同代理人的战略使用，通过访问端口或储存库交付的功能，可以提高治疗潜力。
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公开(公告)号：US20080140008A1
公开(公告)日：2008-06-12
申请号：US11951771
申请日：2007-12-06
CPC分类号： A61M27/006 , A61M25/0102 , A61M25/0108 , A61M2025/0059 , A61M2025/0063 , A61M2025/0293
摘要： An intrathecal catheter for delivering fluid to, or withdrawing fluid from, the cerebrospinal fluid compartment of a patient, includes a proximal end and a distal portion. The distal portion has an outer diameter of about 1 mm or less, a bending stiffness of about 0.002 pounds per square inch or less, and a distal end. A delivery region is located between the proximal end and the distal end, and a lumen extends from the proximal end to the delivery region. The catheter may further include a coiled structure region to prevent dislodgement of the catheter from a tissue in which the coiled structure is implanted, for example the cisterna magna. The catheter may also include tines to anchor portions of the catheter, for example to a portion of the spinal canal.
摘要翻译： 用于将流体输送到患者的脑脊液腔室或从患者的脑脊液腔室排出流体的鞘内导管包括近端和远端部分。 远侧部分具有约1mm或更小的外径，约0.002磅/平方英寸或更小的弯曲刚度和远端。 输送区域位于近端和远端之间，并且内腔从近端延伸到输送区域。 导管还可以包括螺旋结构区域，以防止导管从其中植入线圈结构的组织例如大便池移出。 导管还可以包括用于锚定导管的部分的齿，例如到椎管的一部分。
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公开(公告)号：US5716532A
公开(公告)日：1998-02-10
申请号：US661387
申请日：1996-06-11
CPC分类号： H01G4/012 , H01G13/06 , H01G4/30 , Y10T29/417
摘要： A method of improving the breakdown strength of polymer multi-layer (PML) capacitors is provided. The method comprises removing metal, specifically, aluminum, from the cut edge. This is done by either etching back the metal electrode layers in either basic or acidic solution or by anodizing the metal to cover that portion of the metal at the edge with an oxide. Removing the metal from the cut edge increases the breakdown strength of the PML capacitors by a factor of two or more.
摘要翻译： 提供了一种提高聚合物多层（PML）电容器的击穿强度的方法。 该方法包括从切割边缘去除金属，特别是铝。 这是通过在碱性或酸性溶液中蚀刻金属电极层或通过阳极氧化金属来覆盖边缘处的金属部分以用氧化物来完成的。 从切割边缘去除金属会使PML电容器的击穿强度提高2倍以上。
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7.发明授权Apparatus for delivering single and multiple cardioversion and defibrillation pulses 失效用于输送单个和多个心脏复律和除颤脉冲的装置
公开(公告)号：US5163427A
公开(公告)日：1992-11-17
申请号：US612758
申请日：1990-11-14
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3622
摘要： An implantable cardioverter having circuitry for generating high energy cardioversion and defibrillation pulses. The output circuitry is so configured that it may provide simultaneous pulse, multiple electrode; sequential pulse, multiple electrode; or single pulse, two electrode defibrillation and/or cardioversion pulse regimens. The output circuitry is configured to allow delivery of energy sequentially from two capacitor banks during sequential pulse regimens and to deliver the energy stored in both capacitor banks simultaneously during simultaneous pulse, multiple electrode and single pulse, two electrode defibrillation pulse regimens.
摘要翻译： 具有用于产生高能量心脏复律和除颤脉冲的电路的可植入式心律转复器。 输出电路被配置成可以提供同时的脉冲，多个电极; 顺序脉冲，多电极; 或单脉冲，两电极除颤和/或心脏复律脉冲方案。 输出电路被配置为允许在顺序脉冲方案期间从两个电容器组顺序地递送能量，并且在同时脉冲，多个电极和单个脉冲，两个电极除颤脉冲方案期间同时传送存储在两个电容器组中的能量。
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公开(公告)号：US08500720B2
公开(公告)日：2013-08-06
申请号：US11124984
申请日：2005-05-09
申请人： John G. Keimel
发明人： John G. Keimel
CPC分类号： A61K38/47 , A61K31/713 , A61K38/00 , A61M5/14276 , A61M5/172 , A61M39/0208 , A61M39/04 , A61M2210/125
摘要： The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
摘要翻译： 本发明涉及用于递送心脏病症治疗的系统和方法，其中所述系统包含用于提供含有另外缺乏患有心脏病症的患者的心脏细胞的蛋白质的蛋白质制剂的来源，以及具有 近端和远端，用于将蛋白质制剂递送到人心脏的心包囊区域。
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公开(公告)号：US20090240194A1
公开(公告)日：2009-09-24
申请号：US12476893
申请日：2009-06-02
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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公开(公告)号：US07558629B2
公开(公告)日：2009-07-07
申请号：US11414500
申请日：2006-04-28
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/08 , G06F19/00
摘要： Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
摘要翻译： 描述了允许可植入装置感测来自患者的胃数据和活动数据的技术，并且基于感测的数据估计患者的能量消耗量和消耗的能量。 系统向患者，家庭成员或医生提供关于患者的能量消耗，能量消耗和净能量的反馈。 数据可以以表格或图形格式提供，并且可以显示每天或每周的能量平衡数据，或者可以显示每天或每周能量数据的趋势。 患者可以通过植入式警报模块接收反馈信息，该模块提供和音频警报或振动警报。 此外，由系统获取的数据可以用于调整患者的刺激治疗参数。
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