公开(公告)号：US07585278B2

公开(公告)日：2009-09-08

申请号：US10722074

申请日：2003-11-24

申请人： John Gregory Aceti ,  Zvi Gerald Lowey ,  Richard Morgan Moroney ,  Christopher Carter Gregory ,  Peter John Zanzucchi

发明人： John Gregory Aceti ,  Zvi Gerald Lowey ,  Richard Morgan Moroney ,  Christopher Carter Gregory ,  Peter John Zanzucchi

IPC分类号： A61B5/00

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150511 ,  A61B5/150755 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  G06F19/00

摘要： Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.

公开(公告)号：US08303518B2

公开(公告)日：2012-11-06

申请号：US11311667

申请日：2005-12-20

申请人： John Gregory Aceti ,  Sterling Eduard Mcbride ,  Richard Morgan Moroney ,  Christopher Carter Gregory ,  Peter John Zanzucchi

发明人： John Gregory Aceti ,  Sterling Eduard Mcbride ,  Richard Morgan Moroney ,  Christopher Carter Gregory ,  Peter John Zanzucchi

IPC分类号： A61B5/00

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150076 ,  A61B5/150213 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150526 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/15109 ,  A61B5/15119 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6833 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2209/088 ,  A61M2230/201 ,  G01N33/491

摘要： The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.

摘要翻译： 本发明涉及分析物监测/药物（药剂）递送装置。 本发明适用于监测各种血液成分如葡萄糖。 该装置具有至少部分地包围设置在载体和电子部分上的多个微针的壳体。 每个微针与相应的微通道流体连通。 每个微针都可单独寻址。 也就是说，每个微针可以通过致动器单独地延伸和缩回。 电子部分包括处理器和相关联的电路（例如，存储器，支持电子设备等），电动机等，传感器，电源（例如电池）和可选的接口。 通常，处理器控制设备的操作，并且与致动器，电动机，传感器和接口进行数据通信。 本发明提供自主操作，即不用户干预。 本发明可以任选地提供校准而不需要用户的干预。 本发明还可以提供昼夜半连续监测。 本发明可以提供多达四个或更多周的操作。 本发明可以提供尺寸相对较小并因此不显眼的装置。 本发明还可以为具有远程控制和交互式电子设备的设备提供。 本发明还可以用于递送包括高效药物在内的各种药剂，以最小化患者干预并使不适程度最小化。