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    SILICONE COATED IMPLANT
    2.
    发明申请
    SILICONE COATED IMPLANT 审中-公开
    硅胶涂层

    公开(公告)号：US20130236524A1

    公开(公告)日：2013-09-12

    申请号：US13606795

    申请日：2012-09-07

    申请人： Richard J. HOLL ,  Katherine HARTMAN ,  Stuart A. Grossman ,  Wayne C. Pollock

    发明人： Richard J. HOLL ,  Katherine HARTMAN ,  Stuart A. Grossman ,  Wayne C. Pollock

    IPC分类号： A61K9/00 ,  A61K31/485

    CPC分类号： A61K9/0002 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34

    摘要： Implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants are provided. In particular, subcutaneous drug delivery systems having a biocompatible thermoplastic elastomeric polymer matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible drug impermeable cross-linked silicone polymer coating said matrix and methods of making the same are provided.

    摘要翻译： 提供用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。 特别地，提供了具有生物相容性热塑性弹性体聚合物基质，均匀地嵌入所述基质中的治疗剂和涂覆所述基质的生物相容性药物不可渗透交联的硅氧烷聚合物的皮下药物递送系统及其制备方法。

    TREATMENT SIMULATOR FOR BRAIN DISEASES AND METHOD OF USE THEREOF
    5.
    发明申请
    TREATMENT SIMULATOR FOR BRAIN DISEASES AND METHOD OF USE THEREOF 有权
    脑疾病治疗模拟器及其使用方法

    公开(公告)号：US20090024181A1

    公开(公告)日：2009-01-22

    申请号：US12116765

    申请日：2008-05-07

    申请人： Raghu Raghavan ,  Stuart A. Grossman

    发明人： Raghu Raghavan ,  Stuart A. Grossman

    IPC分类号： A61N1/00 ,  A61B19/00 ,  A61B5/05 ,  G06G7/48

    CPC分类号： A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

    摘要： A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

    摘要翻译： 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

    Methods and systems for providing planning and dispensation of research and/or treatment for brain disease
    7.
    发明授权
    Methods and systems for providing planning and dispensation of research and/or treatment for brain disease 有权
    提供脑部疾病的研究和/或治疗的规划和分配的方法和系统

    公开(公告)号：US09265577B2

    公开(公告)日：2016-02-23

    申请号：US12116765

    申请日：2008-05-07

    申请人： Raghu Raghavan ,  Stuart A. Grossman

    发明人： Raghu Raghavan ,  Stuart A. Grossman

    IPC分类号： A61B19/00 ,  G06T7/00 ,  G06F19/00

    CPC分类号： A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

    摘要： Methods and systems for providing planning and dispensation of research and/or treatment for brain disease. Radiological information is generated in a region of interest in an area of the a brain of an individual using a radiological imaging system. A physiological states model is constructed which assesses physiological states of the region of interest. Locations of sources of interstitial fluid flow, fluid conductivities of paths, and anatomical information in the region of interest are obtained using the radiological imaging information. Velocities of the interstitial fluid flow in the region of interest are computed using the physiological states model, the locations of sources of interstitial flow, the fluid conductivities, and the anatomic information. A model of the area of the brain is created, the model including the region of interest.

    摘要翻译： 提供脑部疾病的研究和/或治疗的规划和分配的方法和系统。 使用放射线成像系统在个体的大脑的区域中的感兴趣区域中产生放射线信息。 构建了一个生理状态模型，评估感兴趣区域的生理状态。 使用放射成像信息获得组织液流的来源的位置，路径的流体电导率和感兴趣区域中的解剖信息。 使用生理状态模型，间质流源，流体电导率和解剖信息来计算感兴趣区域中的间质液流的速度。 创建大脑区域的模型，该模型包括感兴趣的区域。