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    Human growth hormone conjugated with biocompatible polymer
    1.
    发明申请
    Human growth hormone conjugated with biocompatible polymer 审中-公开
    与生物相容性聚合物结合的人生长激素

    公开(公告)号：US20060134736A1

    公开(公告)日：2006-06-22

    申请号：US11314926

    申请日：2005-12-20

    申请人： John Jacobs ,  Shiliang Qin ,  Mingyu Zhang ,  Huaina Li ,  Myung-Ok Park

    发明人： John Jacobs ,  Shiliang Qin ,  Mingyu Zhang ,  Huaina Li ,  Myung-Ok Park

    IPC分类号： C12P21/06 ,  A61K38/27 ,  C07K14/61

    CPC分类号： A61K38/27 ,  A61K47/60 ,  C07K14/61

    摘要： The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 2:1 or less, preferably 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in vivo half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.

    摘要翻译： 本发明涉及生物相容性聚合物和hGH，特别是PEG-hGH的缀合物，其中活化的生物相容性聚合物以2:1或更低，优选1：1的摩尔比与hGH的羧基缀合，制备方法， 和相关的药物组合物。 PEG-hGH缀合物具有高达天然hGH活性的20％，而体内半衰期增加10倍。 PEG-hGH缀合物可用于治疗生长迟缓或生长衰竭，特别是儿童身材矮小以及与老化有关的病症。

    Human growth hormone conjugated with biocompatible polymer
    2.
    发明申请
    Human growth hormone conjugated with biocompatible polymer 审中-公开
    与生物相容性聚合物结合的人生长激素

    公开(公告)号：US20050281778A1

    公开(公告)日：2005-12-22

    申请号：US11187522

    申请日：2005-07-22

    申请人： Myung-Ok Park ,  John Jacobs

    发明人： Myung-Ok Park ,  John Jacobs

    IPC分类号： A61K47/48 ,  A61K38/22

    CPC分类号： C07K14/61 ,  A61K47/60

    摘要： The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in vivo half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.

    摘要翻译： 本发明涉及生物相容性聚合物和hGH，特别是PEG-hGH的缀合物，其中活化的生物相容性聚合物以1：1的摩尔比与hGH的羧基缀合，制备方法和相关药物组合物。 PEG-hGH缀合物具有高达天然hGH活性的20％，而体内半衰期增加10倍。 PEG-hGH缀合物可用于治疗生长迟缓或生长衰竭，特别是儿童身材矮小以及与老化有关的病症。

    Adjustable fastener
    3.
    发明授权
    Adjustable fastener 有权

    公开(公告)号：US10070740B2

    公开(公告)日：2018-09-11

    申请号：US14932188

    申请日：2015-11-04

    申请人： John Jacobs

    发明人： John Jacobs

    IPC分类号： A47G1/16 ,  A47G1/20

    CPC分类号： A47G1/164 ,  A47G1/202 ,  F16B21/073 ,  F16B45/00 ,  F16M11/046 ,  F16M13/02

    摘要： An adjustable fastener is provided. The adjustable fastener includes an elongated main body and a mounting bracket for receiving the main body therein. The elongated main body includes a plurality of teeth along the length of the main body. The mounting bracket includes a latching mechanism disposed on a front face thereof, the latching mechanism having a first end including a release lever and a second end including a plurality of ribs extending into an interior volume of the mounting bracket. The ribs on the second end of the latching mechanism engage with the teeth on the main body to slidably secure the main body within the mounting bracket, thereby providing a vertically adjustable fastener.

    Method, system, and product for data integration through a dynamic common model
    5.
    发明授权
    Method, system, and product for data integration through a dynamic common model 有权
    通过动态共同模型进行数据集成的方法，系统和产品

    公开(公告)号：US07257594B2

    公开(公告)日：2007-08-14

    申请号：US10818618

    申请日：2004-04-06

    申请人： Aderbad Tamboli ,  John Jacobs

    发明人： Aderbad Tamboli ,  John Jacobs

    IPC分类号： G06F17/00

    CPC分类号： G06F17/30569 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99942 ,  Y10S707/99943 ,  Y10S707/99944 ,  Y10S707/99952 ,  Y10S707/99953

    摘要： Data integration including extracting a first native record having a first native format from a first native repository through a first adapter, the first adapter loosely coupled for data integration to a data integration application, the first native format having a datatype; transforming the first native record having first native format to a first native record having dynamic common format, the dynamic common format being a subset of a dynamic common model, the dynamic common model comprising mappings to and from the dynamic common format for all native records in all datatypes; transforming the format of the first native record having dynamic common format to a first native record having second native format; and inserting through a second adapter, also loosely coupled to the application, the first native record the second native format into a second native repository.

    摘要翻译： 数据集成包括通过第一适配器从第一本地存储库提取具有第一原始格式的第一本地记录，第一适配器松散地耦合用于数据集成到数据集成应用，第一本机格式具有数据类型; 将具有第一本机格式的第一原生记录转换为具有动态通用格式的第一原生记录，所述动态通用格式是动态公共模型的子集，所述动态公共模型包括与所有本机记录的动态通用格式的映射 所有数据类型 将具有动态通用格式的第一原生记录的格式转换为具有第二原生格式的第一原生记录; 并且通过也松散地耦合到应用的第二适配器插入第二原生格式到第二本地存储库。

    Tungsten plug corrosion prevention method using gas sparged water
    6.
    发明申请
    Tungsten plug corrosion prevention method using gas sparged water 审中-公开
    钨丝塞防腐方法采用气体喷淋水

    公开(公告)号：US20060048801A1

    公开(公告)日：2006-03-09

    申请号：US11267557

    申请日：2005-11-04

    申请人： John Jacobs ,  Elizabeth Dauch

    发明人： John Jacobs ,  Elizabeth Dauch

    IPC分类号： B08B3/00

    CPC分类号： H01L21/02071 ,  H01L21/6708 ,  H01L21/76838

    摘要： Disclosed herein is a method of making integrated circuits. In one embodiment the method includes forming tungsten plugs in a integrated circuit and forming electrically conductive interconnect lines after formation of the tungsten plugs, wherein at least one tungsten plug is electrically connected to at least one electrically conductive interconnect line. Separate from the formation of the tungsten plugs and electrically conductive interconnect lines, a gas is introduced into a liquid. At least one electrically conductive interconnect line is then contacted with the gas introduced liquid.

    摘要翻译： 本文公开了一种制造集成电路的方法。 在一个实施例中，该方法包括在集成电路中形成钨插塞并且在形成钨插塞之后形成导电互连线，其中至少一个钨插头电连接到至少一个导电互连线。 与钨塞和导电互连线的形成分开，将气体引入液体。 然后至少一个导电互连线与引入气体的液体接触。

    Tungsten plug corrosion prevention method using ionized air
    7.
    发明申请
    Tungsten plug corrosion prevention method using ionized air 失效
    钨丝塞防腐方法采用电离空气

    公开(公告)号：US20050090112A1

    公开(公告)日：2005-04-28

    申请号：US10695528

    申请日：2003-10-28

    申请人： John Jacobs ,  Elizabeth Dauch

    发明人： John Jacobs ,  Elizabeth Dauch

    IPC分类号： H01L21/311 ,  H01L21/768

    CPC分类号： H01L21/76838

    摘要： Disclosed herein is a method of making integrated circuits. In one embodiment the method includes forming tungsten plugs in the integrated circuit and forming electrically conductive interconnect lines in the integrated circuit after formation of the tungsten plugs. At least one tungsten plug is electrically connected to at least one electrically conductive interconnect line. Thereafter at least one electrically conductive interconnect line is exposed to ionized air.

    摘要翻译： 本文公开了一种制造集成电路的方法。 在一个实施例中，该方法包括在集成电路中形成钨插塞并在形成钨插塞之后在集成电路中形成导电互连线。 至少一个钨插塞电连接到至少一个导电互连线。 此后，至少一个导电互连线暴露于电离空气。

    Method of manufacturing composite parts
    9.
    发明申请
    Method of manufacturing composite parts 有权
    复合零件的制造方法

    公开(公告)号：US20120000597A1

    公开(公告)日：2012-01-05

    申请号：US13138551

    申请日：2010-03-01

    申请人： Simon Astwood ,  John Jacobs ,  Matthew Hocking ,  Jago Pridie

    发明人： Simon Astwood ,  John Jacobs ,  Matthew Hocking ,  Jago Pridie

    IPC分类号： B65H81/06

    CPC分类号： B29C70/32 ,  B29C70/44 ,  B29C70/446

    摘要： A method of manufacturing two or more composite parts, the method comprising: assembling the composite parts on a mandrel by laying a series of layers of bands of composite material onto the mandrel with a placement machine,—rotating the mandrel as the bands are laid onto the mandrel; attaching two or more debulk frames (10, 11) to the mandrel between opposed edges of the composite parts after the composite parts have been assembled; wrapping the mandrel, debulk frames (10, 11) and composite parts in a debulk bag; heating the composite parts,—forming a vacuum between the mandrel and the debulk bag so that the debulk bag is sucked into voids between the debulk frames and the heated composite parts and progressively presses against the heated composite parts whereby excess material is squeezed by the debulk bag towards their opposed edges; and removing the debulk bag and the composite parts from the mandrel.

    摘要翻译： 一种制造两个或多个复合部件的方法，所述方法包括：通过将放置机器的一系列复合材料带放置在所述心轴上来将所述复合部件组装在心轴上，当将所述带放置在所述带上时旋转所述心轴 心轴 在复合部件组装之后，在复合部件的相对边缘之间将两个或更多个去磁框架（10,11）连接到心轴上; 将心轴，减压框架（10,11）和复合部件包裹在减压袋中; 加热复合部件，在心轴和去毛刺袋之间形成真空，使得去毛刺袋被吸入脱泡框架和被加热的复合部件之间的空隙中，并逐渐地压靠加热的复合部件，由此多余的材料被除垢剂挤压 袋子朝向相对的边缘; 并从芯棒上去除去毛刺袋和复合部件。