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    MR imaging compositions and methods
    7.
    发明授权
    MR imaging compositions and methods 失效
    MR成像组合物和方法

    公开(公告)号：US5817292A

    公开(公告)日：1998-10-06

    申请号：US960746

    申请日：1992-10-14

    申请人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    发明人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    IPC分类号： A61K49/06 ,  A61K49/12 ,  A61K49/00

    CPC分类号： A61K49/128

    摘要： This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.

    摘要翻译： 本发明提供了可用于MR成像的组合物，其包含包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物，所述聚合物具有与其相关的参与性金属离子。

    Segmented chelating polymers as imaging and therapeutic agents
    8.
    发明授权
    Segmented chelating polymers as imaging and therapeutic agents 失效
    分段螯合聚合物作为成像和治疗剂

    公开(公告)号：US5730968A

    公开(公告)日：1998-03-24

    申请号：US221714

    申请日：1994-03-31

    申请人： Dennis E. Butterfield ,  Dennis K. Fujii ,  David L. Ladd ,  Robert A. Snow ,  Julia S. Tan ,  John L. Toner

    发明人： Dennis E. Butterfield ,  Dennis K. Fujii ,  David L. Ladd ,  Robert A. Snow ,  Julia S. Tan ,  John L. Toner

    IPC分类号： A61K47/48 ,  A61K51/00 ,  C08G65/32 ,  C08G65/329 ,  A61K31/77 ,  A61K49/00 ,  C08G65/48

    CPC分类号： C08G65/329 ,  Y10S530/815 ,  Y10S530/816

    摘要： A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue; Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L; L represents an amide linkage; E.sup.(b) is one or more counterions each having a charge of b; b is an integer from 1, 2 and 3; n is an integer selected from the group 1, 2, 3 and 4; w is zero or an integer from 1 to 5; M.sup.(+a) is a cation, having a charge of +a; a is an integer from 1 to 4; r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation; d is the total charge on the chelating residue and is an integer from 0 to 10; d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; and R is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.4 alkyl, aryl containing 6 to 24 carbon atoms, C.sub.2 -C.sub.5 alkanoyloxyl and C.sub.1 -C.sub.4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group.

    摘要翻译： 适用于诊断成像或细胞杀伤剂的组合物，其包含通过酰胺键与聚（环氧烷）部分连接的螯合残基，所述组合物的分子量至少为4,500; 其中：Z是螯合残基; Q是在R和L具有碳末端的二价聚（亚烷基亚氧烷基）部分; L表示酰胺键; E（b）是一个或多个各自具有b的电荷的抗衡离子; b是1,2和3的整数; n是选自1,2,3,4组的整数; w为0或1〜5的整数; M（+ a）为阳离子，电荷为+ a; a是从1到4的整数; r为0或1〜3的整数，条件是当r为2-3时，每个M（+ a）可以是相同或不同的阳离子; d是螯合残基上的总电荷，为0至10的整数; d + SIGMA（bxw）+ SIGMA（axr）= O; 并且R是选自氢，羟基，C 1 -C 4烷基，含有6至24个碳原子的芳基，C 2 -C 5烷酰氧基和C 1 -C 4烷氧基的封端部分，或R是免疫反应性基团或与 Q通过化学键或连接基团。

    Segmented chelating polymers as imaging and therapeutic agents
    9.
    发明授权
    Segmented chelating polymers as imaging and therapeutic agents 失效
    分段螯合聚合物作为成像和治疗剂

    公开(公告)号：US6017522A

    公开(公告)日：2000-01-25

    申请号：US845421

    申请日：1997-04-25

    申请人： Dennis E. Butterfield ,  Dennis K. Fujii ,  David L. Ladd ,  Robert A. Snow ,  Julia S. Tan ,  John L. Toner

    发明人： Dennis E. Butterfield ,  Dennis K. Fujii ,  David L. Ladd ,  Robert A. Snow ,  Julia S. Tan ,  John L. Toner

    IPC分类号： A61K47/48 ,  A61K51/00 ,  C08G65/32 ,  C08G65/329 ,  A61K31/77 ,  A61K49/00 ,  C08G65/48

    CPC分类号： C08G65/329 ,  Y10S530/815 ,  Y10S530/816

    摘要： A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said compisition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue;Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L;L represents an amide linkage;E.sup.(b) is one or more counterions each having a charge of b;b is an integer from 1, 2 and 3;n is an integer selected from the group 1, 2, 3 and 4;w is zero or an integer from 1 to 5;M.sup.(+a) is a cation, having a charge of +a;a is an integer from 1 to 4;r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation;d is the total charge on the chelating residue and is an integer from 0 to 10;d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; andR is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.4 alkyl, aryl containing 6 to 24 carbon atoms, C.sub.2 -C.sub.5 alkanoyloxyl and C.sub.1 -C.sub.4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group.

    摘要翻译： 适合用于诊断成像的组合物或作为细胞杀伤剂的组合物，其包含通过酰胺键与聚（环氧烷）部分连接的螯合残基，所述制剂具有至少4,500的分子量; 其中：Z是螯合残基; Q是在R和L具有碳末端的二价聚（亚烷基亚氧烷基）部分; L表示酰胺键; E（b）是一个或多个各自具有b的电荷的抗衡离子; b是1,2和3的整数; n是选自1,2,3,4组的整数; w为0或1〜5的整数; M（+ a）为阳离子，电荷为+ a; a是从1到4的整数; r为0或1〜3的整数，条件是当r为2-3时，每个M（+ a）可以是相同或不同的阳离子; d是螯合残基上的总电荷，为0至10的整数; d + SIGMA（bxw）+ SIGMA（axr）= O; 并且R是选自氢，羟基，C 1 -C 4烷基，含有6至24个碳原子的芳基，C 2 -C 5烷酰氧基和C 1 -C 4烷氧基的封端部分，或R是免疫反应性基团或与 Q通过化学键或连接基团。