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公开(公告)号：US09386934B2
公开(公告)日：2016-07-12
申请号：US14117144
申请日：2012-05-11
CPC分类号： A61B5/04001 , A61B5/4848 , A61B5/6846 , A61B5/7203 , A61B5/7285 , A61M5/1723 , A61M2230/08 , A61N1/36071 , A61N1/36125 , A61N1/36135 , A61N1/36146
摘要： A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.
摘要翻译： 用于测量刺激的神经反应的方法。 测量电路在激励之前通过将检测电极连接到测量电路来允许测量电路稳定到生物电定义的稳定状态。 通过将刺激电极彼此短路，在刺激电极上恢复电荷。 然后将电刺激从刺激电极施加到神经组织，同时保持感测电极与测量电路断开连接。 在刺激之后，施加延迟，在该延迟期间刺激电极开路，并且感测电极与测量电路和刺激电极断开。 在延迟之后，通过将感测电极连接到测量电路来测量存在于感测电极处的神经反应信号。
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公开(公告)号：US20150164354A1
公开(公告)日：2015-06-18
申请号：US14117144
申请日：2012-05-11
CPC分类号： A61B5/04001 , A61B5/4848 , A61B5/6846 , A61B5/7203 , A61B5/7285 , A61M5/1723 , A61M2230/08 , A61N1/36071 , A61N1/36125 , A61N1/36135 , A61N1/36146
摘要： A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.
摘要翻译： 用于测量刺激的神经反应的方法。 测量电路在激励之前通过将感测电极连接到测量电路来允许测量电路稳定到生物电定义的稳定状态。 通过将刺激电极彼此短路，在刺激电极上恢复电荷。 然后将电刺激从刺激电极施加到神经组织，同时保持感测电极与测量电路断开连接。 在刺激之后，施加延迟，在该延迟期间刺激电极开路，并且感测电极与测量电路和刺激电极断开。 在延迟之后，通过将感测电极连接到测量电路来测量存在于感测电极处的神经反应信号。
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公开(公告)号：US10568559B2
公开(公告)日：2020-02-25
申请号：US14117140
申请日：2012-05-11
摘要： A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.
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公开(公告)号：US09381356B2
公开(公告)日：2016-07-05
申请号：US14117149
申请日：2012-05-11
申请人： John Louis Parker , James Hamilton Laird , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
发明人： John Louis Parker , James Hamilton Laird , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
CPC分类号： A61N1/36071 , A61B5/04001 , A61B5/4041 , A61B5/407 , A61B5/4821 , A61B5/4824 , A61B5/4836 , A61N1/0551 , A61N1/36139 , A61N1/3615
摘要： An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.
摘要翻译： 可植入装置应用和控制神经刺激。 该装置具有多个电极和用于提供从电极传递到神经通路的刺激的刺激源，以便引起诸如脊髓的神经通路上的动作电位。 控制单元控制由一组参数值定义的神经刺激的应用，并通过测量电路测量诱发的神经复合动作电位响应。 控制单元根据所测量的诱发响应确定反馈变量，并将其与治疗图进行比较。 治疗图定义了控制变量与反馈变量的治疗关系。 刺激参数值中的一个或多个被改变以实现控制变量中所需的改变。 迭代地执行该过程以改善反馈变量与治疗映射随时间的对准。
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公开(公告)号：US09974455B2
公开(公告)日：2018-05-22
申请号：US14117152
申请日：2012-05-11
CPC分类号： A61B5/04001 , A61N1/0551 , A61N1/36071 , A61N1/36135
摘要： An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse Width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.
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公开(公告)号：US20140194771A1
公开(公告)日：2014-07-10
申请号：US14117152
申请日：2012-05-11
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61N1/0551 , A61N1/36071 , A61N1/36135
摘要： An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.
摘要翻译： 用于估计由刺激产生的神经募集的可植入装置具有多个电极。 刺激源提供从电极传递到神经组织的刺激物。 测量电路获得在电极处感测的神经信号的测量。 控制单元被配置为使用所述刺激电极来控制对神经组织的所选刺激的应用; 并且在所选择的神经刺激之后，应用具有短脉冲宽度的探针刺激。 测量由探针刺激诱发的残余神经反应; 并且控制单元从遗留神经反应估计由所选择的神经刺激引起的神经募集。
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