公开(公告)号：US09381356B2

公开(公告)日：2016-07-05

申请号：US14117149

申请日：2012-05-11

Applicant: John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis ,  Milan Obradovic ,  Robert Bruce Gorman

Inventor： John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis ,  Milan Obradovic ,  Robert Bruce Gorman

IPC: A61N1/00 ,  A61N1/36 ,  A61B5/04 ,  A61B5/00 ,  A61N1/05

CPC classification number: A61N1/36071 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/407 ,  A61B5/4821 ,  A61B5/4824 ,  A61B5/4836 ,  A61N1/0551 ,  A61N1/36139 ,  A61N1/3615

Abstract: An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.

Abstract translation: 可植入装置应用和控制神经刺激。 该装置具有多个电极和用于提供从电极传递到神经通路的刺激的刺激源，以便引起诸如脊髓的神经通路上的动作电位。 控制单元控制由一组参数值定义的神经刺激的应用，并通过测量电路测量诱发的神经复合动作电位响应。 控制单元根据所测量的诱发响应确定反馈变量，并将其与治疗图进行比较。 治疗图定义了控制变量与反馈变量的治疗关系。 刺激参数值中的一个或多个被改变以实现控制变量中所需的改变。 迭代地执行该过程以改善反馈变量与治疗映射随时间的对准。

公开(公告)号：US20140194772A1

公开(公告)日：2014-07-10

申请号：US14117153

申请日：2012-05-11

Applicant: Peter Scott Vallack Single ,  James Hamilton Laird

Inventor： Peter Scott Vallack Single ,  James Hamilton Laird

IPC: A61B5/04

Abstract: A device for measuring a neural response evoked by a stimulus. First and second sense electrodes are positioned at distinct locations along a neural pathway. A neural stimulus is applied and first and second recordings of a neural response evoked by the stimulus are obtained from the respective sense electrodes. The first recording and the second recording are compared to determine propagation properties of the evoked neural response.

Abstract translation: 用于测量由刺激诱发的神经反应的装置。 第一和第二感测电极沿着神经通路定位在不同的位置。 应用神经刺激，从相应的感测电极获得由刺激引起的神经反应的第一和第二记录。 比较第一记录和第二记录以确定诱发神经反应的传播特性。

公开(公告)号：US09974455B2

公开(公告)日：2018-05-22

申请号：US14117152

申请日：2012-05-11

Applicant: John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis

Inventor： John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis

IPC: A61B5/04 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B5/04001 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36135

Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse Width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.

公开(公告)号：US09155892B2

公开(公告)日：2015-10-13

申请号：US14117586

申请日：2012-05-11

Applicant: John Louis Parker ,  James Hamilton Laird

Inventor： John Louis Parker ,  James Hamilton Laird

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36139 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36175

Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fiber population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fiber population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronized or desynchronized to give directional control over responses evoked.

Abstract translation: 施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。 刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。 使用电极阵列和刺激的合适的相对定时，诱发反​​应的上升或下降的波段可以被选择性地同步或去同步，以对诱发的响应进行方向控制。

公开(公告)号：US20140243931A1

公开(公告)日：2014-08-28

申请号：US14117586

申请日：2012-05-11

Applicant: John Louis Parker ,  James Hamilton Laird

Inventor： John Louis Parker ,  James Hamilton Laird

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36175

Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.

Abstract translation: 施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。 刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。 使用电极阵列和刺激的合适的相对定时，诱发反​​应的上升或下降的波浪可以被选择性地同步或去同步，以对诱发的响应进行方向控制。

公开(公告)号：US10588524B2

公开(公告)日：2020-03-17

申请号：US14117153

申请日：2012-05-11

Applicant: Peter Scott Vallack Single ,  James Hamilton Laird

Inventor： Peter Scott Vallack Single ,  James Hamilton Laird

IPC: A61B5/04 ,  A61B5/00 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36

Abstract: A device for measuring a neural response evoked by a stimulus. First and second sense electrodes are positioned at distinct locations along a neural pathway. A neural stimulus is applied and first and second recordings of a neural response evoked by the stimulus are obtained from the respective sense electrodes. The first recording and the second recording are compared to determine propagation properties of the evoked neural response.

公开(公告)号：US20140194771A1

公开(公告)日：2014-07-10

申请号：US14117152

申请日：2012-05-11

Applicant: John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis

Inventor： John Louis Parker ,  James Hamilton Laird ,  Dean Michael Karantonis

IPC: A61B5/04

CPC classification number: A61B5/04001 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36135

Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.

Abstract translation: 用于估计由刺激产生的神经募集的可植入装置具有多个电极。 刺激源提供从电极传递到神经组织的刺激物。 测量电路获得在电极处感测的神经信号的测量。 控制单元被配置为使用所述刺激电极来控制对神经组织的所选刺激的应用; 并且在所选择的神经刺激之后，应用具有短脉冲宽度的探针刺激。 测量由探针刺激诱发的残余神经反应; 并且控制单元从遗留神经反应估计由所选择的神经刺激引起的神经募集。