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公开(公告)号：US07749555B2
公开(公告)日：2010-07-06
申请号：US11339781
申请日：2006-01-25
CPC分类号： A61L27/50 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2821 , A61F2002/2835 , A61L2430/02 , Y10S623/919
摘要： The present invention relates to a method for enhancing ingrowth of host bone comprising: modifying a bone graft structure to provide an ionic gradient to produce a modified bone graft structure; and implanting the modified bone graft structure. The present invention also relates to a method of enhancing the binding of growth factors and cell cultures to a bone graft structure comprising: applying ex vivo an effective quantity of an ionic force change agent to the surface of a bone graft structure to produce a binding-sensitized bone graft structure; implanting the binding-sensitized bone graft structure into a host bone; and administering to the binding-sensitized bone graft structure a molecule, a cell culture or a combination thereof.
摘要翻译： 本发明涉及一种用于增强宿主骨向内生长的方法，包括：修饰骨移植结构以提供离子梯度以产生修饰的骨移植结构; 并植入修饰的骨移植结构。 本发明还涉及增强生长因子和细胞培养物与骨移植结构的结合的方法，其包括：将有效量的离子力变化剂离体施加到骨移植结构的表面以产生结合 - 敏化骨移植结构; 将结合敏化的骨移植结构植入宿主骨中; 以及向结合敏化的骨移植结构施用分子，细胞培养物或其组合。
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公开(公告)号：US08029562B2
公开(公告)日：2011-10-04
申请号：US12946585
申请日：2010-11-15
IPC分类号： A61F2/06
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
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公开(公告)号：US20110060402A1
公开(公告)日：2011-03-10
申请号：US12946585
申请日：2010-11-15
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译： 提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体 依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。
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公开(公告)号：US20080234811A1
公开(公告)日：2008-09-25
申请号：US11742433
申请日：2007-04-30
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译： 提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体 依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。
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公开(公告)号：US07923053B2
公开(公告)日：2011-04-12
申请号：US11742433
申请日：2007-04-30
IPC分类号： A61L33/00
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译： 提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体 依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。
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