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    METHODS AND REAGENTS FOR IN VIVO IMAGING OF CANCER CELL LINES
    3.
    发明申请
    METHODS AND REAGENTS FOR IN VIVO IMAGING OF CANCER CELL LINES 审中-公开
    癌细胞系血管成像的方法和试剂

    公开(公告)号：US20090311193A1

    公开(公告)日：2009-12-17

    申请号：US12293982

    申请日：2007-03-23

    申请人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    发明人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    IPC分类号： A61K49/00 ,  C07K16/18

    CPC分类号： G01N33/57484 ,  A61K49/0021 ,  A61K49/0058 ,  G01N33/532 ,  G01N33/54346

    摘要： Provided are reagents and methods for non-invasive in vivo imaging wherein the reagents comprise targeted carrier molecules conjugated to a NIR reporter molecule. In one aspect the targeted carrier molecule is an antibody, or fragment thereof that has specificity for an antigen in a living body, animal or human. In one embodiment the antibodies are anti-cancer/tumor marker antibodies, organ specific antibodies, tissue specific antibodies, cell type specific antibodies, cell surface specific antibodies, anti-viral antibodies, anti-bacterial antibodies and anti-pathogenic antibodies. The NIR reporter molecules are any fluorescent reporter molecule compatible with in vivo imaging and generally having an excitation wavelength of at least 580 nm.

    摘要翻译： 提供了用于非侵入性体内成像的试剂和方法，其中试剂包含与NIR报告分子缀合的靶载体分子。 一方面，靶向载体分子是对活体，动物或人体中的抗原具有特异性的抗体或其片段。 在一个实施方案中，抗体是抗癌/肿瘤标志物抗体，器官特异性抗体，组织特异性抗体，细胞类型特异性抗体，细胞表面特异性抗体，抗病毒抗体，抗细菌抗体和抗致病性抗体。 NIR报告分子是与体内成像相容的任何荧光报道分子，通常具有至少580nm的激发波长。

    Methods and Reagents for in Vivo Imaging of Cancel Cell Lines
    4.
    发明申请
    Methods and Reagents for in Vivo Imaging of Cancel Cell Lines 审中-公开
    取消细胞系体内成像的方法和试剂

    公开(公告)号：US20120253160A1

    公开(公告)日：2012-10-04

    申请号：US13439279

    申请日：2012-04-04

    申请人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    发明人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    IPC分类号： A61B5/1455

    CPC分类号： G01N33/57484 ,  A61K49/0021 ,  A61K49/0058 ,  G01N33/532 ,  G01N33/54346

    摘要： Provided is reagents and methods for non-invasive in vivo imaging wherein the reagents comprise targeted carrier molecules conjugated to a NIB reporter molecule. In one aspect the targeted carrier molecule is an antibody, or fragment thereof that has specificity for an antigen in a living body, animal or human. In one embodiment the antibodes are anti-cancer/tumor marker antibodies, organ specific antibodies, tissue specific antibodies, cell type specific antibodies, cell surface specific antibodies, anti-viral antibodies, anti-bacterial antibodies and anti-pathogenic antibodies. The NIP reporter molecules are any fluorescent reporter molecule compatible with in vivo imaging and generally having an excitation wavelength of at least 580 nm.

    摘要翻译： 提供了用于非侵入性体内成像的试剂和方法，其中试剂包含与NIB报道分子缀合的靶向载体分子。 一方面，靶向载体分子是对活体，动物或人体中的抗原具有特异性的抗体或其片段。 在一个实施方案中，抗菌剂是抗癌/肿瘤标志物抗体，器官特异性抗体，组织特异性抗体，细胞型特异性抗体，细胞表面特异性抗体，抗病毒抗体，抗细菌抗体和抗致病性抗体。 NIP报告分子是与体内成像相容的任何荧光报道分子，通常具有至少580nm的激发波长。

    STABLE COMPOSITIONS COMPRISING CHROMOGENIC COMPOUNDS AND METHODS OF USE
    5.
    发明申请
    STABLE COMPOSITIONS COMPRISING CHROMOGENIC COMPOUNDS AND METHODS OF USE 审中-公开
    包含色素化合物的稳定组合物和使用方法

    公开(公告)号：US20120077211A1

    公开(公告)日：2012-03-29

    申请号：US13139873

    申请日：2009-12-15

    申请人： Lawrence Greenfield ,  Shawn Starkenburg ,  Matthew Shallice ,  Julie Nyhus ,  Louis Leong

    发明人： Lawrence Greenfield ,  Shawn Starkenburg ,  Matthew Shallice ,  Julie Nyhus ,  Louis Leong

    IPC分类号： G01N33/53 ,  C12Q1/28 ,  C09K3/00 ,  C07C211/54

    CPC分类号： G01N33/532 ,  C01B15/037

    摘要： Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection. The compositions, assays, methods, and kits disclosed herein make use of a novel, stabilized formulation of DAB and a novel, stabilized formulation of hydrogen peroxide.

    摘要翻译： 公开了组合物，测定法，方法和试剂盒，用于利用显色电子给体如二氨基联苯胺（DAB）氧化产生信号的应用中。 应用包括但不限于免疫组化，显色原位杂交，Western印迹，Northern印迹，Southern印迹，ELISA测定和微阵列检测。 本文公开的组合物，测定方法和试剂盒使用DAB的新型稳定制剂和新型稳定的过氧化氢制剂。