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    METHODS AND REAGENTS FOR IN VIVO IMAGING OF CANCER CELL LINES
    3.
    发明申请
    METHODS AND REAGENTS FOR IN VIVO IMAGING OF CANCER CELL LINES 审中-公开
    癌细胞系血管成像的方法和试剂

    公开(公告)号：US20090311193A1

    公开(公告)日：2009-12-17

    申请号：US12293982

    申请日：2007-03-23

    申请人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    发明人： John Mauro ,  Thomas Steinberg ,  Julie Nyhus

    IPC分类号： A61K49/00 ,  C07K16/18

    CPC分类号： G01N33/57484 ,  A61K49/0021 ,  A61K49/0058 ,  G01N33/532 ,  G01N33/54346

    摘要： Provided are reagents and methods for non-invasive in vivo imaging wherein the reagents comprise targeted carrier molecules conjugated to a NIR reporter molecule. In one aspect the targeted carrier molecule is an antibody, or fragment thereof that has specificity for an antigen in a living body, animal or human. In one embodiment the antibodies are anti-cancer/tumor marker antibodies, organ specific antibodies, tissue specific antibodies, cell type specific antibodies, cell surface specific antibodies, anti-viral antibodies, anti-bacterial antibodies and anti-pathogenic antibodies. The NIR reporter molecules are any fluorescent reporter molecule compatible with in vivo imaging and generally having an excitation wavelength of at least 580 nm.

    摘要翻译： 提供了用于非侵入性体内成像的试剂和方法，其中试剂包含与NIR报告分子缀合的靶载体分子。 一方面，靶向载体分子是对活体，动物或人体中的抗原具有特异性的抗体或其片段。 在一个实施方案中，抗体是抗癌/肿瘤标志物抗体，器官特异性抗体，组织特异性抗体，细胞类型特异性抗体，细胞表面特异性抗体，抗病毒抗体，抗细菌抗体和抗致病性抗体。 NIR报告分子是与体内成像相容的任何荧光报道分子，通常具有至少580nm的激发波长。

    Optical transmitter with enhanced SBS threshold power capability
    4.
    发明申请
    Optical transmitter with enhanced SBS threshold power capability 审中-公开
    具有增强SBS阈值功率能力的光发射机

    公开(公告)号：US20070140704A1

    公开(公告)日：2007-06-21

    申请号：US11314106

    申请日：2005-12-20

    申请人： John Mauro ,  Srikanth Raghavan

    发明人： John Mauro ,  Srikanth Raghavan

    IPC分类号： H04B10/04

    CPC分类号： H04B10/2575 ,  H04B10/2537

    摘要： An optical transmitter (8) having enhanced stimulated Brillouin scattering (SBS) threshold power (PSBS) capability is disclosed. The transmitter includes a light source (12) adapted to emit a continuous-wave (CW) light beam (16). A phase modulator (20) is optically coupled to the light source and to a plurality n of radio-frequency (RF) signal drivers (22) adapted to generate a corresponding plurality of sinusoidal RF drive signals having respective modulation amplitudes An, modulation frequencies fn, and modulation phases φn. The phase modulator phase modulates the light beam based on the plurality of sinusoidal RF drive signals to form a phase-modulated carrier light beam (16′). The modulation phases φn are chosen to increase the SBS threshold power relative to a baseline threshold power when the phase-modulated carrier light beam travels over an optical fiber (50). Modulation frequencies fn are also chosen to suppress combined second-order (CSO) distortion.

    摘要翻译： 公开了具有增强的受激布里渊散射（SBS）阈值功率（PSBS）能力的光发射机（8）。 发射机包括适于发射连续波（CW）光束（16）的光源（12）。 相位调制器（20）光耦合到光源和多个n个射频（RF）信号驱动器（22），其适于产生具有相应调制幅度A N的对应的多个正弦RF驱动信号 调制频率f n n n和调制相位φn n。 相位调制器基于多个正弦RF驱动信号调制光束，以形成相位调制载波光束（16'）。 当相位调制的载波光束在光纤（50）上行进时，选择调制相位phi N以提高相对于基线阈值功率的SBS阈值功率。 还选择调制频率f N n N以抑制组合二阶（CSO）失真。

    Continuous, real time monitor for airborne depleted uranium particles in the respiratory range and corresponding method of use
    7.
    发明授权
    Continuous, real time monitor for airborne depleted uranium particles in the respiratory range and corresponding method of use 有权

    公开(公告)号：US10031060B2

    公开(公告)日：2018-07-24

    申请号：US15649626

    申请日：2017-07-13

    申请人： John Mauro & Associates, LLC

    发明人： John Mauro

    IPC分类号： G01N15/06 ,  G01N15/02 ,  G01N23/20

    摘要： A continuous alpha monitor includes an air intake mechanism, which in turn includes an air mover, an air intake prefilter that limits particulates in the air intake mechanism to an aerodynamic diameter of 10 microns or less, and a particle detector mounted downstream of the air intake prefilter, the air particle detector providing a first airborne dust concentration and a first distribution of aerodynamic diameters of particulates in air passing the prefilter, the particulates including depleted uranium particulates. The monitor further includes a movable sample filter web that collects the particulates; a solid state detector that detects alpha radiation emitted by the collected particulates; a processor that executes machine instructions embodied on a non-transient computer-readable storage medium to compute a dust loading on the sample filter web; and the processor computes an indication of alpha concentration detected by the solid state detector.

    Optical fiber with low second order distortion
    10.
    发明申请
    Optical fiber with low second order distortion 失效
    具有低二阶失真的光纤

    公开(公告)号：US20070189769A1

    公开(公告)日：2007-08-16

    申请号：US11357277

    申请日：2006-02-16

    申请人： John Mauro ,  Srikanth Raghavan

    发明人： John Mauro ,  Srikanth Raghavan

    IPC分类号： H04J14/00

    CPC分类号： H04J14/0298 ,  H04B10/2525 ,  H04B10/272 ,  H04N7/22

    摘要： An optical fiber system comprising: (i) a dispersion pre-compensator including dispersion compensating fiber DCF characterized by the overall dispersion value DDCF at the operating wavelength λ; and (ii) a passive optical network (PON) including a plurality of transmission paths provided by a plurality of optical fibers, said plurality of transmission paths having a minimum and maximum dispersion value DMIN and DMAX; wherein the dispersion pre-compensator includes an output port operatively coupled to an input port of the a passive optical network and −DMAX

    摘要翻译： 一种光纤系统，包括：（i）色散预补偿器，包括以工作波长λ为特征的色散补偿光纤DCF，其特征在于总色散值D DCF < 和（ii）包括由多根光纤提供的多个传输路径的无源光网络（PON），所述多个传输路径具有最小和最大色散值D MIN和D MAX ; 其中所述色散预补偿器包括可操作地耦合到所述无源光网络的输入端口的输出端口，并且具有D＆lt; MAX＆lt; D＆gt; 。