Pharmaceutical formulations for dry powder inhalers
    2.
    发明申请
    Pharmaceutical formulations for dry powder inhalers 有权
    干粉吸入器的药物制剂

    公开(公告)号:US20090269412A1

    公开(公告)日:2009-10-29

    申请号:US12386758

    申请日:2009-04-21

    IPC分类号: A61K9/16

    摘要: A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

    摘要翻译: 用于干粉吸入器的粉末包括:i)由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的一部分; ii)一部分粗颗粒; 和iii)至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地,本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂,可以以简单的方式产生,物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。

    Pharmaceutical formulations for dry powder inhalers
    7.
    发明授权
    Pharmaceutical formulations for dry powder inhalers 有权
    干粉吸入器的药物制剂

    公开(公告)号:US07541022B2

    公开(公告)日:2009-06-02

    申请号:US10257886

    申请日:2001-04-17

    IPC分类号: A61K9/14 A61K9/16

    摘要: A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

    摘要翻译: 用于干粉吸入器的粉末包括:i)由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的分数n; ii)一部分粗颗粒; 和iii)至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地,本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂,可以以简单的方式产生,物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。

    METERED-DOSE INHALER AND METHOD OF USING THE SAME
    9.
    发明申请
    METERED-DOSE INHALER AND METHOD OF USING THE SAME 审中-公开
    计量吸入器及其使用方法

    公开(公告)号:US20120055467A1

    公开(公告)日:2012-03-08

    申请号:US13226017

    申请日:2011-09-06

    IPC分类号: A61M11/00 A61M16/14

    摘要: A metered-dose inhaler includes at least one vessel and an actuator for receiving the at least one vessel. The at least one vessel includes a first reservoir containing a first formulation and a second reservoir containing a second formulation. The metered-dose inhaler is actuable when the at least one vessel is received by the actuator. The metered-dose inhaler is configured to simultaneously deliver a first metered dose of the first formulation and a second metered dose of the second formulation upon actuation.

    摘要翻译: 计量吸入器包括至少一个容器和用于容纳至少一个容器的致动器。 所述至少一个容器包括含有第一制剂的第一储存器和含有第二制剂的第二储存器。 当至少一个容器被致动器接收时,计量吸入器是致动的。 计量吸入器构造成在致动时同时递送第一制剂的第一计量剂量和第二制剂的第二计量剂量。

    Aerosol inhaler
    10.
    发明申请
    Aerosol inhaler 审中-公开
    气溶胶吸入器

    公开(公告)号:US20050034720A1

    公开(公告)日:2005-02-17

    申请号:US10168546

    申请日:2001-01-02

    IPC分类号: A61K9/00 A61M15/00 A61M11/00

    摘要: A device for delivering metered aerosols g an active ingredient in solution in a propellant consisting of a hydrofluoroalkane (HFA), selected from 1,1,1,2-tetrafluoroethane (HFA 134a), 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) or mixtures thereof, a co-solvent such as ethanol and optionally a low-volatility component preferably selected from glycerol, propylene glycol polyethylene glycol, oleic acid and isopropyl myristate, said device comprising a flat body with a seat for housing the can, an inhalation mouthpiece and an expansion chamber shaped to create a vortex flow of the aerosol particles expelled by the actuator, wherein the actuator orifice diameter is in the range between 0.30 and 0.50 mm.

    摘要翻译: 一种用于递送计量气溶胶的装置,其是在由选自1,1,1,2-四氟乙烷(HFA 134a),1,1,1,2,3,3(3))中的氢氟烷烃(HFA)组成的推进剂的溶液中的活性成分 ,3-七氟丙烷(HFA 227)或其混合物,共溶剂如乙醇和任选的低挥发性组分,优选选自甘油,丙二醇聚乙二醇,油酸和肉豆蔻酸异丙酯,所述装置包括具有 用于容纳罐的吸入口和膨胀室,其形成为产生由致动器排出的气溶胶颗粒的涡流,其中致动器孔直径在0.30和0.50mm之间的范围内。