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    Pharmaceutical formulations for dry powder inhalers
    4.
    发明申请
    Pharmaceutical formulations for dry powder inhalers 有权
    干粉吸入器的药物制剂

    公开(公告)号：US20090269412A1

    公开(公告)日：2009-10-29

    申请号：US12386758

    申请日：2009-04-21

    申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzo Ferrarini

    发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzo Ferrarini

    IPC分类号： A61K9/16

    CPC分类号： A61K9/16 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1682 ,  A61K31/167 ,  A61K31/58

    摘要： A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

    摘要翻译： 用于干粉吸入器的粉末包括：i）由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的一部分; ii）一部分粗颗粒; 和iii）至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地，本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂，可以以简单的方式产生，物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。

    Mouthpiece for a particulate inhaler
    5.
    发明授权
    Mouthpiece for a particulate inhaler 失效
    颗粒吸入器的口腔

    公开(公告)号：US06810875B2

    公开(公告)日：2004-11-02

    申请号：US10283418

    申请日：2002-11-18

    申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

    发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

    IPC分类号： B65D8306

    CPC分类号： A61M15/0065 ,  A61M11/002 ,  A61M15/0021 ,  A61M2202/064 ,  A61M2206/14

    摘要： Mouthpieces for particulate inhalers typically have either stationary particle deflectors or rotatable devices for changing the flow of particulate material through the mouthpiece. However, these mouthpieces do not prevent the build up of particulate drug on the walls of the mouthpiece. Thus, there is provided a mouthpiece (10) for use in an inhaler for particulate medicament, the mouthpiece having an inlet (12) and an outlet (13) for particulate medicament, a helical member (15) disposed between the inlet and the outlet for, in use, imparting a rotational movement to an air flow which is drawn through the mouthpiece and in which medicament is entrained, wherein the helical member (15) is, in use, axially movable between a first position and a second position such that it restricts the build up of medicament on the inside of the mouthpiece (10).