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16 条记录 (耗时 0.026 秒)

    Fast contact measuring machine
    4.
    发明授权
    Fast contact measuring machine 失效
    快速接触测量机

    公开(公告)号：US5129152A

    公开(公告)日：1992-07-14

    申请号：US630577

    申请日：1990-12-20

    申请人： John R. Barr

    发明人： John R. Barr

    IPC分类号： G01B5/02

    CPC分类号： G01B5/02 ,  Y10S707/99952 ,  Y10S707/99954

    摘要： A pair of anvils (50,54) are respectively fixed to and movable with respect to a base (12). Each anvil has a surface (52,56) of given topography, preferably a flat surface. The surfaces are spaced in parallel from one another at an initial gap so that the anvil surfaces do not contact one another. The movable anvil (50) can be moved away from the fixed anvil (54), such as by a cam (44) and follower (38), and the surfaces are maintained in parallel preferably by a parallelogram constant force flexure assembly (26). The cam is set to maintain a minimum space between the surfaces and to protect them from damage, in the event the movable anvil were accidently dropped towards the non-movable anvil. Parallelism between the surfaces is initially established preferably by an adjustment mechanism comprising a trivet/turnbuckle assembly (58). A displacement transducer (22) is coupled to the movable anvil for measuring the gap as determined by the thickness of a gage or product placed between the surfaces of the anvils. By orienting the movable anvil above the stationary anvil, gravity can be used to urge the movable anvil into contact with the gage or product.

    摘要翻译： 一对砧座（50,54）分别固定到基座（12）上并可相对于基座（12）移动。 每个砧具有给定形貌的表面（52,56），优选地是平坦表面。 表面在初始间隙处彼此平行地间隔开，使得砧座表面不彼此接触。 可移动砧座（50）可以例如由凸轮（44）和从动件（38）移动远离固定砧座（54），并且这些表面优选地由平行四边形的恒力弯曲组件（26）保持平行， 。 凸轮被设置为在表面之间保持最小的空间，并且在可动砧被意外地向不可动砧移动的情况下保护它们免受损坏。 最初通过包括三角/螺丝扣组件（58）的调节机构来建立表面之间的平行度。 位移传感器（22）联接到可移动砧座上，用于测量由砧座或砧座表面之间的产品的厚度确定的间隙。 通过将可动砧定位在固定砧座上方，可以使用重力来推动活动砧与量规或产品接触。

    DETECTION OF ANTHRAX PATHOGENICITY FACTORS
    5.
    发明申请
    DETECTION OF ANTHRAX PATHOGENICITY FACTORS 有权
    检测ANTHRAX致病因子

    公开(公告)号：US20120122123A1

    公开(公告)日：2012-05-17

    申请号：US11675233

    申请日：2007-02-15

    申请人： ANNE E. BOYER ,  Conrad P. Quinn ,  John R. Barr

    发明人： ANNE E. BOYER ,  Conrad P. Quinn ,  John R. Barr

    IPC分类号： G01N33/566 ,  G01N21/64 ,  C12M1/34

    CPC分类号： G01N33/56911 ,  G01N2333/32 ,  G01N2500/00

    摘要： One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, a patient may be days beyond the time when treatment would be effective by the time a diagnosis is made. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax lethal factor activity exhibited by the instant invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines and lethal factor inhibitors. The instant invention isolates and concentrates lethal factor and lethal toxin from nearly any biological sample. By capitalizing on the endopeptidase activity of lethal factor the present invention amplifies output signals producing reliable detection of picomolar concentrations of lethal factor. The instant invention involves novel purification and detection techniques and substrates for rapid, reproducible, and quantitative measurements of anthrax lethal factor in biological samples.

    摘要翻译： 目前可用于炭疽的诊断方法的一个主要问题是这些方法需要几天才能产生结果。 炭疽病唯一现有的治疗方法需要在感染后立即进行治疗，当时患者只出现轻微的流感样症状。 因此，患者可能是在诊断时治疗有效的时间。 本发明将诊断时间缩短至少于4小时，同时提供炭疽的同一天鉴定，从而大大增加了提供适当治疗和患者恢复的几率。 本发明显示的炭疽致死因子活性的快速鉴定也适用于发现和发展炭疽疫苗和致死因子抑制剂的体内筛选方案。 本发明从几乎任何生物样品中分离和浓缩致死因子和致死毒素。 通过利用致死因子的内肽酶活性，本发明扩增了产生对皮摩尔浓度致死因子的可靠检测的输出信号。 本发明涉及用于生物样品中炭疽致死因子的快速，可重复和定量测量的新颖的纯化和检测技术和底物。

    Priority-based admission control in a network with variable channel data rates
    6.
    发明授权
    Priority-based admission control in a network with variable channel data rates 有权
    具有可变信道数据速率的网络中基于优先级的接纳控制

    公开(公告)号：US07860002B2

    公开(公告)日：2010-12-28

    申请号：US12173804

    申请日：2008-07-15

    申请人： Whay Chiou Lee ,  John R. Barr ,  Stephen P. Emeott ,  Ravishankar Ramamirtham ,  S. David Silk

    发明人： Whay Chiou Lee ,  John R. Barr ,  Stephen P. Emeott ,  Ravishankar Ramamirtham ,  S. David Silk

    IPC分类号： H04L1/00

    CPC分类号： H04W74/0875 ,  H04L47/14 ,  H04L47/24 ,  H04W28/22

    摘要： A method for priority-based admission control in a network, comprises receiving an admission request for transmitting an information flow to a network through a communication channel and determining an admissible region within a range of a channel data rate of a communication channel for an information flow in response to a priority of the information flow, where the priority of the information flow is one of a plurality of priorities of information flow. The admissible region is one of a plurality of admissible regions within the channel data rate range that correspond to different ones of the plurality of priorities of information flow, respectively, and each of the plurality of admissible regions within the channel data rate range is useable for transmitting information flow with a respective one of the plurality of priorities. Further included in the method is determining an available channel data rate of the communication channel for receiving the information flow by the network, and granting the admission request for the information flow after determining that the available channel data rate of the communication channel is within the admissible region of the channel data rate range.

    摘要翻译： 一种用于网络中基于优先权的接纳控制的方法，包括：通过通信信道接收用于向网络发送信息流的准入请求，并且确定用于信息流的通信信道的信道数据速率范围内的允许区域 响应于信息流的优先级，其中信息流的优先级是信息流的多个优先级之一。 允许区域是信道数据速率范围内的多个允许区域之一，其对应于信息流的多个优先级中的不同优先级，并且信道数据速率范围内的多个允许区域中的每一个可用于 以所述多个优先级中的相应一个发送信息流。 该方法还包括：确定用于由网络接收信息流的通信信道的可用信道数据速率，以及在确定通信信道的可用信道数据速率在可允许的范围之内之前授予信息流的准入请求 区域的通道数据速率范围。

    DETECTION OF ADENYLATE CYCLASE
    8.
    发明申请
    DETECTION OF ADENYLATE CYCLASE 审中-公开
    检测腺苷酸环化酶

    公开(公告)号：US20130210031A1

    公开(公告)日：2013-08-15

    申请号：US13878378

    申请日：2011-11-08

    申请人： Anne E. Boyer ,  Renato C. Lins ,  Zsuzsanna Kuklenyik ,  Maribel Gallegos-Candela ,  Conrad P. Quinn ,  John R. Barr

    发明人： Anne E. Boyer ,  Renato C. Lins ,  Zsuzsanna Kuklenyik ,  Maribel Gallegos-Candela ,  Conrad P. Quinn ,  John R. Barr

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56911 ,  C12Q1/527 ,  G01N2333/32 ,  G01N2333/988

    摘要： One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result, are rendered unusable after antibiotic use, or are not quantifiable. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, by the time a diagnosis is made a patient may be days beyond the time when treatment would be effective. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax edema factor activity exhibited by the invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines, anti-toxins and edema factor inhibitors. The invention isolates and concentrates edema factor and edema toxin from nearly any sample. By capitalizing on the adenylate cyclase activity of edema factor the invention amplifies output signals producing reliable detection of low concentrations of edema factor previously unachievable. The invention involves novel purification and detection techniques and substrates for rapid, reproducible, and quantitative measurements of anthrax edema factor, and other adenylate cyclases in biological samples.

    摘要翻译： 目前可用于炭疽的诊断方法中的一个主要问题是这些方法需要几天才能产生结果，在使用抗生素后不能使用，或不能量化。 炭疽病唯一现有的治疗方法需要在感染后立即进行治疗，当时患者只出现轻微的流感样症状。 因此，在进行诊断的时候，患者可以是治疗有效的时间。 本发明将诊断时间缩短至少于4小时，同时提供炭疽的同一天鉴定，从而大大增加了提供适当治疗和患者恢复的几率。 本发明显示的炭疽水肿因子活性的快速鉴定也适用于发现和发展炭疽疫苗，抗毒素和水肿因子抑制剂的体内筛选方案。 本发明从几乎任何样品中分离并浓缩水肿因子和水肿毒素。 通过利用水肿因子的腺苷酸环化酶活性，本发明放大了产生可靠检测低浓度水肿因子的输出信号，这是先前无法实现的。 本发明涉及用于快速，可重复和定量测量生物样品中炭疽水肿因子和其他腺苷酸环化酶的新型纯化和检测技术和底物。

    COLLABORATIVE SEARCHING
    9.
    发明申请
    COLLABORATIVE SEARCHING 有权
    协同搜索

    公开(公告)号：US20100153413A1

    公开(公告)日：2010-06-17

    申请号：US12335885

    申请日：2008-12-16

    申请人： Swee M. Mok ,  William P. Alberth ,  John R. Barr ,  Jonathan R. Engelsma ,  Steven F. Gillig ,  Xiang Xu

    发明人： Swee M. Mok ,  William P. Alberth ,  John R. Barr ,  Jonathan R. Engelsma ,  Steven F. Gillig ,  Xiang Xu

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30867 ,  G06F17/30678 ,  G06F17/30702

    摘要： Disclosed are techniques that allow users to collaborate in a search. Each user can contribute to an original search and to refining the results of the search. Preferences of all of the users are considered in the search even while those preferences can be kept private. In some embodiments of the present invention, at least two users each submit a search query. The multiple search queries are logically combined to produce one set of search results. The results can be reviewed by the users and refined if necessary. In some embodiments, a search query can be specified by a single user, but the search engine takes into consideration the stored preferences of multiple users (in addition to the search query itself, of course).

    摘要翻译： 公开了允许用户在搜索中协作的技术。 每个用户可以对原始搜索做出贡献，并提炼搜索结果。 即使这些偏好可以保持私密，所有用户的偏好都在搜索中被考虑。 在本发明的一些实施例中，至少两个用户每个提交搜索查询。 多个搜索查询被逻辑组合以产生一组搜索结果。 结果可以由用户审查，如有必要，进行细化。 在一些实施例中，搜索查询可以由单个用户指定，但是搜索引擎考虑到存储的多个用户的偏好（当然，除了搜索查询本身之外）。

    Collaborative searching
    10.
    发明授权
    Collaborative searching 有权
    协同搜索

    公开(公告)号：US08090732B2

    公开(公告)日：2012-01-03

    申请号：US12335885

    申请日：2008-12-16

    申请人： Swee M. Mok ,  William P. Alberth ,  John R. Barr ,  Jonathan R. Engelsma ,  Steven F. Gillig ,  Xiang Xu

    发明人： Swee M. Mok ,  William P. Alberth ,  John R. Barr ,  Jonathan R. Engelsma ,  Steven F. Gillig ,  Xiang Xu

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/30867 ,  G06F17/30678 ,  G06F17/30702

    摘要： Each user can contribute to an original search and to refining the results of the search. Preferences of all of the users are considered in the search even while those preferences can be kept private. In some embodiments of the present invention, at least two users each submit a search query. The multiple search queries are logically combined to produce one set of search results. The results can be reviewed by the users and refined if necessary. In some embodiments, a search query can be specified by a single user, but the search engine takes into consideration the stored preferences of multiple users (in addition to the search query itself, of course).

    摘要翻译： 每个用户可以对原始搜索做出贡献，并提炼搜索结果。 即使这些偏好可以保持私密，所有用户的偏好都在搜索中被考虑。 在本发明的一些实施例中，至少两个用户每个提交搜索查询。 多个搜索查询被逻辑组合以产生一组搜索结果。 结果可以由用户审查，如有必要，进行细化。 在一些实施例中，搜索查询可以由单个用户指定，但是搜索引擎考虑到存储的多个用户的偏好（当然，除了搜索查询本身之外）。