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公开(公告)号：US09101925B2
公开(公告)日：2015-08-11
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的屏障，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US09101926B2
公开(公告)日：2015-08-11
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120065048A1
公开(公告)日：2012-03-15
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01D21/26
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120065047A1
公开(公告)日：2012-03-15
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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5.发明授权Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权从骨髓或脐带血中回收的干细胞和祖细胞组成; 系统及其制备方法公开(公告)号：US08167139B2
公开(公告)日：2012-05-01
申请号：US11825542
申请日：2007-07-06
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
摘要翻译： 本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。 本发明还包括用于制备组合物的系统和方法。 该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。 该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。 处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。
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6.发明授权Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权从骨髓或脐带血中回收的干细胞和祖细胞组成; 系统及其制备方法公开(公告)号：US09050422B2
公开(公告)日：2015-06-09
申请号：US13385951
申请日：2012-03-15
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
摘要翻译： 本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。 本发明还包括用于制备组合物的系统和方法。 该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。 该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。 处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。
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公开(公告)号：US20120171762A1
公开(公告)日：2012-07-05
申请号：US13385951
申请日：2012-03-15
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
IPC分类号： C12N5/0789
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
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公开(公告)号：US20130045852A1
公开(公告)日：2013-02-21
申请号：US13199129
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks
发明人： John R. Chapman , Rodney Sparks
CPC分类号： B01D21/26 , A61M1/3693 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2200/026 , B01L2300/0864 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.
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9.发明授权公开(公告)号：US09095798B2
公开(公告)日：2015-08-04
申请号：US13199129
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks
发明人： John R. Chapman , Rodney Sparks
CPC分类号： B01D21/26 , A61M1/3693 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2200/026 , B01L2300/0864 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。 在容器内使用中密度流体以进一步分离不同密度的成分。
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公开(公告)号：US20120193274A1
公开(公告)日：2012-08-02
申请号：US13506145
申请日：2012-03-30
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
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