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公开(公告)号：US20130045852A1
公开(公告)日：2013-02-21
申请号：US13199129
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks
发明人： John R. Chapman , Rodney Sparks
CPC分类号： B01D21/26 , A61M1/3693 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2200/026 , B01L2300/0864 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.
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2.发明授权公开(公告)号：US09095798B2
公开(公告)日：2015-08-04
申请号：US13199129
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks
发明人： John R. Chapman , Rodney Sparks
CPC分类号： B01D21/26 , A61M1/3693 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2200/026 , B01L2300/0864 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。 在容器内使用中密度流体以进一步分离不同密度的成分。
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公开(公告)号：US09101926B2
公开(公告)日：2015-08-11
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120065048A1
公开(公告)日：2012-03-15
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01D21/26
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120065047A1
公开(公告)日：2012-03-15
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US09101925B2
公开(公告)日：2015-08-11
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的屏障，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120193274A1
公开(公告)日：2012-08-02
申请号：US13506145
申请日：2012-03-30
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
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公开(公告)号：US20120122649A1
公开(公告)日：2012-05-17
申请号：US13374983
申请日：2012-01-26
IPC分类号： B01D43/00
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
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9.发明授权Mass spectrometer system including an ion source operable under high pressure conditions, and a two-stage pumping arrangement 失效包括在高压条件下可操作的离子源的质谱仪系统和两级泵送装置
公开(公告)号：US5164593A
公开(公告)日：1992-11-17
申请号：US662468
申请日：1991-02-28
摘要： A mass spectrometer system includes an ion source effective to produce ions within a viscous flow region. A pumping arrangement is effective to produce a further viscous flow region of lower pressure than the first region, ions passing through the further region into a molecular flow region. The energy of the ions is defined as they enter the molecular flow region.
摘要翻译： 质谱仪系统包括有效地在粘性流动区域内产生离子的离子源。 泵送装置有效地产生比第一区域更低的压力的另外的粘性流动区域，离子通过另外的区域进入分子流动区域。 离子的能量定义为它们进入分子流动区域。
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公开(公告)号：US20120213754A1
公开(公告)日：2012-08-23
申请号：US13398739
申请日：2012-02-16
申请人： John R. Chapman
发明人： John R. Chapman
CPC分类号： C12N5/0653 , A61J1/10 , A61K35/12 , A61K35/14 , A61K35/15 , A61K35/16 , A61K35/18 , A61K35/19 , B65D81/266 , C12N5/0647 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02
摘要： An apparatus for the preparation of cells for implantation into a living body is disclosed. The apparatus comprises a vessel substantially impermeable to gaseous oxygen; and fluid within said vessel, the fluid having a maximal dissolved oxygen capacity substantially equivalent to normal saline yet having a hypoxic oxygen concentration between about 0% to about 5% of said maximal dissolved oxygen capacity. The bag oxygen concentration level remains low when the apparatus is stored at 22°-25° C. in normal atmospheric conditions for a period of at least 30 days. The present invention simplifies the process of achieving donor cell hypoxic preconditioning for cell implantation, and may be used to bathe said cells to be transplanted for a sufficient time to activate the hypoxic metabolic pathway.
摘要翻译： 公开了一种用于制备用于植入生物体的细胞的装置。 该装置包括基本上不透气态的容器; 和所述容器内的流体，所述流体具有基本上等于生理盐水的最大溶解氧能力，但是具有在所述最大溶解氧容量的约0％至约5％之间的缺氧氧浓度。 当装置在正常大气条件下在22°-25℃下储存至少30天时，袋氧浓度水平保持较低。 本发明简化了用于细胞植入的供体细胞缺氧预处理的过程，并且可以用于洗涤待移植的细胞足够的时间以激活缺氧代谢途径。
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