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公开(公告)号：US20110027776A1
公开(公告)日：2011-02-03
申请号：US11909678
申请日：2006-03-28
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2). The methods involve assessing occurrence in the human's genome of the NQO1*2 polymorphism of the NQO1 gene. Occurrence of a copy of the polymorphism indicates that the human can benefit from dietary supplementation with CoQH2, and occurrence of two copies (i.e., homozygosity) of the NQO1*2 polymorphism indicates that dietary supplementation with CoQH2 can be especially desirable.
摘要翻译： 本发明涉及用于评估补充还原型辅酶Q（CoQH2）的人的饮食的期望性的试剂盒和方法。 该方法涉及评估人类基因组中NQO1基因NQO1 * 2多态性的发生情况。 多态性拷贝的发生表明，人可以从CoQH2的膳食补充中受益，并且NQO1 * 2多态性的两个拷贝（即，纯合性）的发生表明可以特别需要膳食补充CoQH2。
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公开(公告)号：US20110294126A1
公开(公告)日：2011-12-01
申请号：US13195585
申请日：2011-08-01
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing the susceptibility of a human to oxidative stress or damage. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with oxidative stress and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kit for performing the methods.
摘要翻译： 本发明涉及用于评估人类对氧化应激或损伤的易感性的试剂盒和方法。 所述方法涉及评估人类基因组中发生在与氧化应激相关并与人类疾病相关的一个或多个基因中的一种或多种多态性（例如，单核苷酸多态性）的发生。 公开了优选的评估和评分方法，以及用于执行方法的试剂盒。
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公开(公告)号：US20130011838A1
公开(公告)日：2013-01-10
申请号：US13546883
申请日：2012-07-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing the susceptibility of a human to oxidative stress or damage. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with oxidative stress and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kit for performing the methods.
摘要翻译： 本发明涉及用于评估人类对氧化应激或损伤的易感性的试剂盒和方法。 所述方法涉及评估人类基因组中发生在与氧化应激相关并与人类疾病相关的一个或多个基因中的一种或多种多态性（例如，单核苷酸多态性）的发生。 公开了优选的评估和评分方法，以及用于执行方法的试剂盒。
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公开(公告)号：US08313930B2
公开(公告)日：2012-11-20
申请号：US11731180
申请日：2007-03-30
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing skin health for a human and the human's susceptibility to skin disorders. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated disclosed herein and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kits for performing the methods.
摘要翻译： 本发明涉及用于评估人的皮肤健康和人类对皮肤病的易感性的试剂盒和方法。 所述方法涉及评估在人类基因组中发生在本文公开的一种或多种相关基因并且与人类疾病相关的一个或多个多态性（例如，单核苷酸多态性）中的发生。 公开了优选的评估和评分方法，以及用于执行方法的套件。
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公开(公告)号：US07211383B2
公开(公告)日：2007-05-01
申请号：US10247935
申请日：2002-09-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing skin health for a human and the human's susceptibility to skin disorders. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated disclosed herein and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kits for performing the methods.
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公开(公告)号：US08278342B2
公开(公告)日：2012-10-02
申请号：US12537083
申请日：2009-08-06
申请人： Robert P. Ricciardi
发明人： Robert P. Ricciardi
IPC分类号： A61K31/40
CPC分类号： A61K31/65 , A61K31/095 , A61K31/10 , A61K31/166 , A61K31/198 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/42 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/473 , A61K31/496 , A61K31/519
摘要： This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula XVII which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula XVII can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.
摘要翻译： 本发明提供了通过使痘病毒与具有式XVII的化合物接触来抑制痘病毒复制的方法，其又减少，抑制或消除痘病毒DNA聚合酶活性和/或其与其活性因子的相互作用。 式XVII可用于治疗患有痘病毒感染的人和动物。 还提供了用于治疗痘病毒感染的受试者的药物组合物。
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7.发明申请METHODS FOR ASSESSING THE SUSCEPTIBILITY OF A HUMAN TO DIMINISHED HEALTH AND WELLNESS 审中-公开评估人类对维持健康和健康的不确定性的方法公开(公告)号：US20120164647A1
公开(公告)日：2012-06-28
申请号：US13415530
申请日：2012-03-08
申请人： Robert P. Ricciardi
发明人： Robert P. Ricciardi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： The present invention relates to methods for assessing the advisability that a human should employ a compensatory composition comprised of one or more antioxidant ingredients. The methods involve assessing occurrence in the human's genome of a plurality of certain polymorphisms. Methods for determining the composition of preferred compensatory compositions are also disclosed.
摘要翻译： 本发明涉及用于评估人应该使用由一种或多种抗氧化成分组成的补偿性组合物的可取性的方法。 该方法涉及评估人类基因组中多种某些多态性的发生。 还公开了确定优选补偿组合物组成的方法。
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8.发明申请Methods for Assessing the Susceptibility of a Human to Diminished Health and Wellness 审中-公开评估人类对健康和健康减退的敏感性的方法公开(公告)号：US20100304373A1
公开(公告)日：2010-12-02
申请号：US12541486
申请日：2009-08-14
申请人： Robert P. Ricciardi
发明人： Robert P. Ricciardi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： The present invention relates to methods for assessing the advisability that a human should employ a compensatory composition comprised of one or more antioxidant ingredients. The methods involve assessing occurrence in the human's genome of a plurality of certain polymorphisms. Methods for determining the composition of preferred compensatory compositions are also disclosed.
摘要翻译： 本发明涉及用于评估人应该使用由一种或多种抗氧化成分组成的补偿性组合物的可取性的方法。 该方法涉及评估人类基因组中多种某些多态性的发生。 还公开了确定优选补偿组合物组成的方法。
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公开(公告)号：US20090053343A1
公开(公告)日：2009-02-26
申请号：US12259528
申请日：2008-10-28
申请人： Robert P. Ricciardi
发明人： Robert P. Ricciardi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention relates to kits and methods for assessing susceptibility of a human to abnormal lipid metabolism and disorders associated therewith, such as obesity and diabetes. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with leptin-mediated lipid metabolism and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kits for performing the methods.
摘要翻译： 本发明涉及用于评估人类与异常脂质代谢及其相关疾病如肥胖和糖尿病的易感性的试剂盒和方法。 所述方法涉及评估人类基因组中发生在与瘦蛋白介导的脂质代谢相关并且与人类疾病相关的一个或多个基因中发生的一个或多个多态性（例如，单核苷酸多态性）的发生。 公开了优选的评估和评分方法，以及用于执行方法的套件。
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公开(公告)号：US4562155A
公开(公告)日：1985-12-31
申请号：US496000
申请日：1983-05-19
CPC分类号： C12N15/85 , C12N2710/10322 , C12N2710/16622 , C12N2710/22022 , Y10S435/849
摘要： pML BK is a hybrid plasmid which is constructed of :pML which contains the entire nucleotide sequence of the plasmid pBR322 except for deletion of nucleotide sequences 1120-2490 bp and 0 to 375 bp, and BK which contains the entire nucleotide sequence of the Gardner strain of BK virus except for deletion of nucleotide sequences between bp 5089-5196. Into the pML BK plasmid may be inserted a viral or human gene X to be expressed, an example of which is TK which represents the Bam HI generated 3,600 bp DNA fragment of herpes simplex virus type 1 which contains the herpes simplex virus type 1 TK DNA. The majority of the pML BK X DNA molecules remain in the episomal or free state in the human cells 143B and express the gene X.
摘要翻译： pML BK是由以下构成的杂交质粒：pML，其含有质粒pBR322的全部核苷酸序列，除了缺失1120-2490bp和0至375bp的核苷酸序列，以及含有加德纳菌株的全部核苷酸序列的BK 的BK病毒，除了bp 5089-5196之间的核苷酸序列的缺失。 可以将pMLBK质粒插入待表达的病毒或人基因X，其实例是表示Bam HI的TK，其产生含有单纯疱疹病毒1型TK DNA的3,600bp的单纯疱疹病毒DNA片段 。 大多数pML BK X DNA分子在人类细胞143B中保持在游离状态或自由状态，并表达基因X.
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