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公开(公告)号：US20150030657A1
公开(公告)日：2015-01-29
申请号：US13696051
申请日：2011-05-03
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61F2/042 , A61L27/3826 , A61L2430/22
摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.
摘要翻译： 本发明涉及在有需要的受试者中使用自体或非自体细胞群体接种的支架的再生，重建，增加或替代，所述自体或非自体细胞群是衍生自相应器官或组织结构的或不衍生自相应器官或组织结构的支架 重建，重建，增加或更换的主题。
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公开(公告)号：US08337485B2
公开(公告)日：2012-12-25
申请号：US12612606
申请日：2009-11-04
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US09271824B2
公开(公告)日：2016-03-01
申请号：US13682614
申请日：2012-11-20
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US20130173015A1
公开(公告)日：2013-07-04
申请号：US13682614
申请日：2012-11-20
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US10030242B2
公开(公告)日：2018-07-24
申请号：US13697206
申请日：2011-05-12
申请人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
发明人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
IPC分类号： C12N15/113 , C12N5/071 , C12Q1/6883
摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
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公开(公告)号：US20100131075A1
公开(公告)日：2010-05-27
申请号：US12612606
申请日：2009-11-04
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US10077442B2
公开(公告)日：2018-09-18
申请号：US13697206
申请日：2011-05-12
申请人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
发明人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
IPC分类号： C07H21/02 , C07H21/04 , A61K48/00 , C12N15/113 , C12N5/071 , C12Q1/6883
CPC分类号： C12N15/113 , C12N5/0686 , C12N2310/141 , C12N2320/30 , C12N2320/32 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178
摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
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公开(公告)号：US20130330364A1
公开(公告)日：2013-12-12
申请号：US13883433
申请日：2011-11-10
申请人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
发明人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
CPC分类号： A61K35/22 , A61K45/06 , A61L27/222 , A61L27/54 , A61L2400/06 , A61L2430/26
摘要： The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.
摘要翻译： 本发明涉及含有活性剂，这种生物活性细胞群体的治疗制剂及其制备和使用方法。
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公开(公告)号：US09724367B2
公开(公告)日：2017-08-08
申请号：US13883433
申请日：2011-11-10
申请人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
发明人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
IPC分类号： A61F13/00 , A61K9/14 , A61K31/74 , A61K38/00 , A61K38/16 , A61K47/00 , A61K35/22 , A61L27/22 , A61L27/54 , A61K45/06
CPC分类号： A61K35/22 , A61K45/06 , A61L27/222 , A61L27/54 , A61L2400/06 , A61L2430/26
摘要： The present invention concerns phase changing injectable formulations for organ augmentation containing active agents, such as bioactive cell populations, and methods of making and using the same.
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公开(公告)号：US20200216816A1
公开(公告)日：2020-07-09
申请号：US16624523
申请日：2018-06-21
申请人： Timothy A. BERTRAM , Deepak JAIN
发明人： Timothy A. Bertram , Deepak Jain , Joydeep Basu , John W. Ludlow
摘要： Provided herein are, inter alia, compositions and methods for using genetically modified bioactive renal cell populations to provide regenerative effects to a native kidney for the treatment of chronic kidney disease. In certain embodiments, the aim is to effectively provide a “universal donor” immune-privileged renal cell population where gene editing is used to generate a modified allogeneic renal cell population to be administered to patients without immunosuppression.
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