公开(公告)号：US10030242B2

公开(公告)日：2018-07-24

申请号：US13697206

申请日：2011-05-12

申请人： Timothy A. Bertram ,  Roger M. Ilagan ,  Russell W. Kelley ,  Sharon C. Presnell ,  Sumana Choudhury ,  Andrew T. Bruce ,  Christopher W. Genheimer ,  Bryan R. Cox ,  Kelly I. Guthrie ,  Joydeep Basu ,  Shay M. Wallace ,  Eric Werdin ,  Oluwatoyin A. Knight ,  Namrata D. Sangha ,  John W. Ludlow ,  Craig R. Halberstadt ,  Richard Payne ,  Neil F. Robins ,  Darell McCoy ,  Deepak Jain ,  Manuel J. Jayo ,  Elias A. Rivera ,  Thomas Spencer ,  Benjamin Watts

发明人： Timothy A. Bertram ,  Roger M. Ilagan ,  Russell W. Kelley ,  Sharon C. Presnell ,  Sumana Choudhury ,  Andrew T. Bruce ,  Christopher W. Genheimer ,  Bryan R. Cox ,  Kelly I. Guthrie ,  Joydeep Basu ,  Shay M. Wallace ,  Eric Werdin ,  Oluwatoyin A. Knight ,  Namrata D. Sangha ,  John W. Ludlow ,  Craig R. Halberstadt ,  Richard Payne ,  Neil F. Robins ,  Darell McCoy ,  Deepak Jain ,  Manuel J. Jayo ,  Elias A. Rivera ,  Thomas Spencer ,  Benjamin Watts

IPC分类号： C12N15/113 ,  C12N5/071 ,  C12Q1/6883

摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

公开(公告)号：US10077442B2

公开(公告)日：2018-09-18

申请号：US13697206

申请日：2011-05-12

申请人： Timothy A. Bertram ,  Roger M. Ilagan ,  Russell W. Kelley ,  Sharon C. Presnell ,  Sumana Choudhury ,  Andrew T. Bruce ,  Christopher W. Genheimer ,  Bryan R. Cox ,  Kelly I. Guthrie ,  Joydeep Basu ,  Shay M. Wallace ,  Eric Werdin ,  Oluwatoyin A. Knight ,  Namrata D. Sangha ,  John W. Ludlow ,  Craig R. Halberstadt ,  Richard Payne ,  Neil F. Robins ,  Darell McCoy ,  Deepak Jain ,  Manuel J. Jayo ,  Elias A. Rivera ,  Thomas Spencer ,  Benjamin Watts

发明人： Timothy A. Bertram ,  Roger M. Ilagan ,  Russell W. Kelley ,  Sharon C. Presnell ,  Sumana Choudhury ,  Andrew T. Bruce ,  Christopher W. Genheimer ,  Bryan R. Cox ,  Kelly I. Guthrie ,  Joydeep Basu ,  Shay M. Wallace ,  Eric Werdin ,  Oluwatoyin A. Knight ,  Namrata D. Sangha ,  John W. Ludlow ,  Craig R. Halberstadt ,  Richard Payne ,  Neil F. Robins ,  Darell McCoy ,  Deepak Jain ,  Manuel J. Jayo ,  Elias A. Rivera ,  Thomas Spencer ,  Benjamin Watts

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  C12N15/113 ,  C12N5/071 ,  C12Q1/6883

CPC分类号： C12N15/113 ,  C12N5/0686 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/32 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/178

摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

公开(公告)号：US20150030657A1

公开(公告)日：2015-01-29

申请号：US13696051

申请日：2011-05-03

申请人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha ,  Jacob E. Shokes ,  Teresa B. Burnette ,  Sarah A. Boyd ,  Craig R. Halberstadt ,  Dominic M. Justewicz ,  Elias A. Rivera ,  Wendy Sharp ,  Neil F. Robbins

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha ,  Jacob E. Shokes ,  Teresa B. Burnette ,  Sarah A. Boyd ,  Craig R. Halberstadt ,  Dominic M. Justewicz ,  Elias A. Rivera ,  Wendy Sharp ,  Neil F. Robbins

IPC分类号： A61K35/34

CPC分类号： A61K35/34 ,  A61F2/042 ,  A61L27/3826 ,  A61L2430/22

摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.

摘要翻译： 本发明涉及在有需要的受试者中使用自体或非自体细胞群体接种的支架的再生，重建，增加或替代，所述自体或非自体细胞群是衍生自相应器官或组织结构的或不衍生自相应器官或组织结构的支架 重建，重建，增加或更换的主题。

公开(公告)号：US08337485B2

公开(公告)日：2012-12-25

申请号：US12612606

申请日：2009-11-04

申请人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

IPC分类号： A61M27/00 ,  A61F2/04 ,  B05D5/00

CPC分类号： A61F2/042 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3882 ,  A61L2430/22 ,  C08L67/04

摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

摘要翻译： 本发明涉及使用不衍生​​自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。

公开(公告)号：US09271824B2

公开(公告)日：2016-03-01

申请号：US13682614

申请日：2012-11-20

申请人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

IPC分类号： A61F2/04 ,  A61M27/00 ,  A61L27/18 ,  A61L27/38

CPC分类号： A61F2/042 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3882 ,  A61L2430/22 ,  C08L67/04

摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

摘要翻译： 本发明涉及使用不衍生​​自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。

公开(公告)号：US20130173015A1

公开(公告)日：2013-07-04

申请号：US13682614

申请日：2012-11-20

申请人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

IPC分类号： A61F2/04

CPC分类号： A61F2/042 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3882 ,  A61L2430/22 ,  C08L67/04

摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

摘要翻译： 本发明涉及使用不衍生​​自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。

公开(公告)号：US20100131075A1

公开(公告)日：2010-05-27

申请号：US12612606

申请日：2009-11-04

申请人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

发明人： John W. Ludlow ,  Manuel J. Jayo ,  Joydeep Basu ,  Timothy A. Bertram ,  Christopher W. Genheimer ,  Kelly I. Guthrie ,  Roger M. Ilagan ,  Deepak Jain ,  Oluwatoyin A. Knight ,  Richard Payne ,  Sarah F. Quinlan ,  H. Scott Rapoport ,  Namrata D. Sangha

IPC分类号： A61F2/04 ,  B05D5/00

CPC分类号： A61F2/042 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3882 ,  A61L2430/22 ,  C08L67/04

摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

摘要翻译： 本发明涉及使用不衍生​​自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。

公开(公告)号：US20110224800A1

公开(公告)日：2011-09-15

申请号：US13043252

申请日：2011-03-08

申请人： John W. Ludlow ,  Kelly I. Guthrie ,  Andrew T. Bruce ,  Kenny Johnson

发明人： John W. Ludlow ,  Kelly I. Guthrie ,  Andrew T. Bruce ,  Kenny Johnson

IPC分类号： A61F2/04

CPC分类号： A61L27/3804 ,  A61F2/042 ,  A61L27/3882 ,  A61L2430/22

摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of organs or tissue structures using scaffolds and cells derived from peritoneal tissue.

摘要翻译： 本发明涉及使用来自腹膜组织的支架和细胞的器官或组织结构的再生，重建，增强或替代。

公开(公告)号：US07297784B2

公开(公告)日：2007-11-20

申请号：US10351641

申请日：2003-01-24

申请人： Shawn Barney ,  Kelly I. Guthrie ,  Gene Merutka ,  Mohmed K. Anwer ,  Dennis M. Lambert

发明人： Shawn Barney ,  Kelly I. Guthrie ,  Gene Merutka ,  Mohmed K. Anwer ,  Dennis M. Lambert

IPC分类号： C07H21/04 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/62 ,  C07K5/1021 ,  C07K5/1024 ,  C07K14/59 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2760/18522 ,  Y02A50/465

摘要： The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent.

摘要翻译： 本发明涉及最初衍生自增强其所连接的核心多肽的药代动力学性质的各种逆转录病毒包膜（gp41）蛋白质序列的增强子肽序列。 本发明基于以下发现：包含与核心多肽连接的增强子肽序列的杂合多肽具有增强的药代动力学性质，例如增加的半衰期。 本发明还涉及通过将增强子肽序列与核心多肽连接来增强任何核心多肽的药代动力学性质的方法。 用于本发明实践的核心多肽可包括可用于例如治疗或预防试剂的任何药理学上有用的肽。

公开(公告)号：US06562787B1

公开(公告)日：2003-05-13

申请号：US09834784

申请日：2001-04-13

申请人： Shawn Barney ,  Kelly I. Guthrie ,  Gene Merutka ,  Mohmed K. Anwer ,  Dennis M. Lambert

发明人： Shawn Barney ,  Kelly I. Guthrie ,  Gene Merutka ,  Mohmed K. Anwer ,  Dennis M. Lambert

IPC分类号： A61K3816

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/62 ,  C07K5/1021 ,  C07K5/1024 ,  C07K14/59 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2760/18522

摘要： The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent.