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公开(公告)号：US20150030657A1
公开(公告)日：2015-01-29
申请号：US13696051
申请日：2011-05-03
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61F2/042 , A61L27/3826 , A61L2430/22
摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.
摘要翻译： 本发明涉及在有需要的受试者中使用自体或非自体细胞群体接种的支架的再生，重建，增加或替代，所述自体或非自体细胞群是衍生自相应器官或组织结构的或不衍生自相应器官或组织结构的支架 重建，重建，增加或更换的主题。
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公开(公告)号：US08337485B2
公开(公告)日：2012-12-25
申请号：US12612606
申请日：2009-11-04
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US09271824B2
公开(公告)日：2016-03-01
申请号：US13682614
申请日：2012-11-20
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US20130173015A1
公开(公告)日：2013-07-04
申请号：US13682614
申请日：2012-11-20
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US20100131075A1
公开(公告)日：2010-05-27
申请号：US12612606
申请日：2009-11-04
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha
CPC分类号： A61F2/042 , A61L27/18 , A61L27/3804 , A61L27/3826 , A61L27/3882 , A61L2430/22 , C08L67/04
摘要： The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
摘要翻译： 本发明涉及使用不衍生自这些器官或组织的支架和自体细胞进行器官或组织结构的再生，重建，修复，增强或替换。
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公开(公告)号：US10077442B2
公开(公告)日：2018-09-18
申请号：US13697206
申请日：2011-05-12
申请人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
发明人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
IPC分类号： C07H21/02 , C07H21/04 , A61K48/00 , C12N15/113 , C12N5/071 , C12Q1/6883
CPC分类号： C12N15/113 , C12N5/0686 , C12N2310/141 , C12N2320/30 , C12N2320/32 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178
摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
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公开(公告)号：US10030242B2
公开(公告)日：2018-07-24
申请号：US13697206
申请日：2011-05-12
申请人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
发明人： Timothy A. Bertram , Roger M. Ilagan , Russell W. Kelley , Sharon C. Presnell , Sumana Choudhury , Andrew T. Bruce , Christopher W. Genheimer , Bryan R. Cox , Kelly I. Guthrie , Joydeep Basu , Shay M. Wallace , Eric Werdin , Oluwatoyin A. Knight , Namrata D. Sangha , John W. Ludlow , Craig R. Halberstadt , Richard Payne , Neil F. Robins , Darell McCoy , Deepak Jain , Manuel J. Jayo , Elias A. Rivera , Thomas Spencer , Benjamin Watts
IPC分类号： C12N15/113 , C12N5/071 , C12Q1/6883
摘要： The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
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公开(公告)号：US08318484B2
公开(公告)日：2012-11-27
申请号：US12617721
申请日：2009-11-12
申请人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
IPC分类号： C12N5/00
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译： 本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群的方法，以及用细胞群治疗需要的受试者的方法。
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公开(公告)号：US20110117162A1
公开(公告)日：2011-05-19
申请号：US12617721
申请日：2009-11-12
申请人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译： 本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群的方法，以及用细胞群治疗需要的受试者的方法。
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公开(公告)号：US20110123455A1
公开(公告)日：2011-05-26
申请号：US12945436
申请日：2010-11-12
申请人： Sharon C. Presnell , Thomas Spencer , Belinda J. Wagner , Manuel J. Jayo , Timothy Bertram , Roger M. Ilagan , Russell W. Kelly , H. Scott Rapoport , Andrew Bruce
发明人： Sharon C. Presnell , Thomas Spencer , Belinda J. Wagner , Manuel J. Jayo , Timothy Bertram , Roger M. Ilagan , Russell W. Kelly , H. Scott Rapoport , Andrew Bruce
CPC分类号： G01N33/5088 , G01N2333/475 , G01N2333/52 , G01N2800/347
摘要： The present invention concerns a non-biased, combinatorial approach to the identification of components that modulate a regenerative response in a target tissue, thereby restoring or partially restoring homeostasis to the target tissue. The methods of the present invention are based on in vivo testing, with or without prior in vitro predictive functional testing or combinatorial testing.
摘要翻译： 本发明涉及用于鉴定调节靶组织中的再生应答的组分的非偏置组合方法，从而恢复或部分恢复到目标组织的体内平衡。 本发明的方法基于体内测试，具有或不具有先前的体外预测功能测试或组合测试。
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