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    PRIMATE T-LYMPHOTROPIC VIRUSES
    1.
    发明申请
    PRIMATE T-LYMPHOTROPIC VIRUSES 有权
    主要的T淋巴细菌病毒

    公开(公告)号：US20140080121A1

    公开(公告)日：2014-03-20

    申请号：US14032914

    申请日：2013-09-20

    申请人： Johns Hopkins University ,  The Government of the United States of America as represented by the Secretary of the Department of

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  Eitel Mpoudi Ngole

    IPC分类号： C12Q1/70

    CPC分类号： C12Q1/701 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12Q1/70

    摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

    摘要翻译： 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

    NOVEL SIMIAN T-CELL LYMPHOTROPIC VIRUS
    3.
    发明申请
    NOVEL SIMIAN T-CELL LYMPHOTROPIC VIRUS 审中-公开
    新颖的SIMIAN T细胞淋巴瘤病毒

    公开(公告)号：US20140186383A1

    公开(公告)日：2014-07-03

    申请号：US14013947

    申请日：2013-08-29

    申请人： Johns Hopkins University ,  The Government of the U.S.A. as Represented by the Secretary of the Department of He

    发明人： William M. Switzer ,  Walid Heneine ,  Thomas M. Folks ,  Nathan D. Wolfe ,  Donald S. Burke ,  David M. Sintasath

    IPC分类号： C07K14/005 ,  G01N33/569 ,  C07K16/10

    CPC分类号： C07K14/005 ,  C07K16/1036 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/14021 ,  C12N2740/14022 ,  C12N2740/14043 ,  G01N33/56983

    摘要： Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which include isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed.

    摘要翻译： 公开了3型亚型T型细胞淋巴细胞病毒（STLV-3亚型D），编码STLV-3亚型D多肽的分离的核酸分子，例如STLV-3亚型D包膜，蛋白酶，聚合酶，tax，rex， 和衣壳多肽，由这种核酸编码的分离的多肽。 还公开了用于检测STLV-3亚型D的方法，例如通过检测样品中的STLV-3亚型D核酸或多肽。 因此，公开了用于检测STLV-3亚型D核酸或多肽的探针，引物和抗体。 还公开了包含编码STLV-3亚型D多肽的分离的核酸分子或由这种核酸分子编码的分离的多肽的治疗组合物。