公开(公告)号：US09744038B2

公开(公告)日：2017-08-29

申请号：US12899407

申请日：2010-10-06

申请人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

发明人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

IPC分类号： A61M31/00 ,  A61F2/24 ,  A61B17/04 ,  A61B17/00 ,  A61B17/22

CPC分类号： A61F2/2445 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0485 ,  A61B2017/00331 ,  A61B2017/0409 ,  A61B2017/0437 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/22038 ,  A61F2/2454

摘要： A medical apparatus positionable in a cavity of a bodily organ (e.g., a heart) may constrict a bodily orifice (e.g., a mitral valve). The medical apparatus may include tissue anchors that are implanted in the annulus of the orifice. The tissue anchors may be guided into position by an intravascularly or percutaneously deployed anchor guiding frame. Constriction of the orifice may be accomplished by cinching a flexible cable attached to implanted tissue anchors. The medical device may be used to approximate the septal and lateral (clinically referred to as anterior and posterior) annulus of the mitral valve in order to move the posterior leaflet anteriorly and the anterior leaflet posteriorly and thereby improve leaflet coaptation and eliminate mitral regurgitation.

公开(公告)号：US20110022166A1

公开(公告)日：2011-01-27

申请号：US12899407

申请日：2010-10-06

申请人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

发明人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0485 ,  A61B2017/00331 ,  A61B2017/0409 ,  A61B2017/0437 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/22038 ,  A61F2/2454

摘要： A medical apparatus positionable in a cavity of a bodily organ (e.g., a heart) may constrict a bodily orifice (e.g., a mitral valve). The medical apparatus may include tissue anchors that are implanted in the annulus of the orifice. The tissue anchors may be guided into position by an intravascularly or percutaneously deployed anchor guiding frame. Constriction of the orifice may be accomplished by cinching a flexible cable attached to implanted tissue anchors. The medical device may be used to approximate the septal and lateral (clinically referred to as anterior and posterior) annulus of the mitral valve in order to move the posterior leaflet anteriorly and the anterior leaflet posteriorly and thereby improve leaflet coaptation and eliminate mitral regurgitation.

摘要翻译： 可以定位在身体器官（例如心脏）的空腔中的医疗器械可以收缩身体孔口（例如二尖瓣）。 医疗设备可以包括植入孔口的环空中的组织锚。 组织锚固件可以通过血管内或经皮部署的锚定引导框架被引导到位置。 孔的收缩可以通过将附接到植入的组织锚的柔性电缆束紧来实现。 可以使用医疗装置来近似二尖瓣的间隔和侧向（临床称为前后）环，以便向前移动后叶和前叶，从而改善小叶接合并消除二尖瓣反流。

公开(公告)号：US20090287304A1

公开(公告)日：2009-11-19

申请号：US12120195

申请日：2008-05-13

申请人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

发明人： Jon Dahlgren ,  Doug Goertzen ,  Daniel Gelbart

IPC分类号： A61B17/12 ,  A61F2/24

CPC分类号： A61F2/2445 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0485 ,  A61B2017/00331 ,  A61B2017/0409 ,  A61B2017/0437 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/22038 ,  A61F2/2454

摘要： A medical apparatus positionable in a cavity of a bodily organ (e.g., a heart) may constrict a bodily orifice (e.g., a mitral valve). The medical apparatus may include tissue anchors that are implanted in the annulus of the orifice. The tissue anchors may be guided into position by an intravascularly or percutaneously deployed anchor guiding frame. Constriction of the orifice may be accomplished by cinching a flexible cable attached to implanted tissue anchors. The medical device may be used to approximate the septal and lateral (clinically referred to as anterior and posterior) annulus of the mitral valve in order to move the posterior leaflet anteriorly and the anterior leaflet posteriorly and thereby improve leaflet coaptation and eliminate mitral regurgitation.

摘要翻译： 可以定位在身体器官（例如心脏）的空腔中的医疗器械可以收缩身体孔口（例如二尖瓣）。 医疗设备可以包括植入孔口的环空中的组织锚。 组织锚固件可以通过血管内或经皮部署的锚定引导框架被引导到位置。 孔的收缩可以通过将附接到植入的组织锚的柔性电缆束紧来实现。 可以使用医疗装置来近似二尖瓣的间隔和侧向（临床称为前后）环，以便向前移动后叶和前叶，从而改善小叶接合并消除二尖瓣反流。

公开(公告)号：US20090131930A1

公开(公告)日：2009-05-21

申请号：US11941819

申请日：2007-11-16

申请人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

发明人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

IPC分类号： A61B18/04

CPC分类号： A61B18/1492 ,  A61B5/06 ,  A61B5/065 ,  A61B5/4875 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/025

摘要： A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

摘要翻译： 可以在身体器官（例如心脏）的空腔中定位的装置可以区分流体（例如血液）和非流体组织（例如，心脏壁），以提供信息或指示位置和/或 器件在腔中的取向。 歧视可以基于流量或其他一些特性，例如电容率或力。 该装置可以基于信息或映射来选择性地烧蚀非流体组织的部分。 该装置可以检测指示消融是否成功的特征（例如，电位）。 该装置可以包括多个换能器，以未膨胀的构造血管内引导并且以扩张构型定位在非流体组织附近。 膨胀机构可以包括螺旋构件或可膨胀构件。

公开(公告)号：US09023058B2

公开(公告)日：2015-05-05

申请号：US12246614

申请日：2008-10-07

申请人： Jorge Jaramillo ,  Doug Goertzen ,  Kevin Chaplin ,  Daniel Gelbart

发明人： Jorge Jaramillo ,  Doug Goertzen ,  Kevin Chaplin ,  Daniel Gelbart

IPC分类号： A61B17/10 ,  A61B17/88 ,  A61B17/04 ,  A61B17/82 ,  A61B19/00

CPC分类号： A61B17/8869 ,  A61B17/04 ,  A61B17/0467 ,  A61B17/823 ,  A61B17/8861 ,  A61B2017/0496 ,  A61B2090/064 ,  A61B2090/0807

摘要： A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place and maintain the tension previously achieved. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed.

摘要翻译： 可以使用外科器械将张力施加到柔性缝合线上以闭合并固定破碎或切割的骨（例如在胸骨切开后的胸骨）。 该装置优选地将可调节的张力施加到柔性缝合线上，以将骨头固定在一起。 多个器械可以一起使用以确保用柔性缝合线固定的整个骨结构施加期望的张力。 一旦实现所需的张力，该装置优选地提供一种机制，以将均匀的扭转施加到柔性缝合线以将柔性缝线锁定在适当位置并保持先前​​实现的张力。 该装置可以自动切割柔性缝合线，或者一旦执行了扭转动作，则可以由外科医生切割柔性缝合线。

公开(公告)号：US20100087836A1

公开(公告)日：2010-04-08

申请号：US12246614

申请日：2008-10-07

申请人： Jorge Jaramillo ,  Doug Goertzen ,  Kevin Chaplin ,  Daniel Gelbart

发明人： Jorge Jaramillo ,  Doug Goertzen ,  Kevin Chaplin ,  Daniel Gelbart

IPC分类号： A61B17/12 ,  A61B17/10

CPC分类号： A61B17/8869 ,  A61B17/04 ,  A61B17/0467 ,  A61B17/823 ,  A61B17/8861 ,  A61B2017/0496 ,  A61B2090/064 ,  A61B2090/0807

摘要： A surgical instrument may be used to apply tension to a flexible suture to close and secure a broken or cut bone (e.g. a sternum following a sternotomy). The device preferably applies an adjustable tension to the flexible suture in order to secure the bone together. Multiple instruments may be used together to ensure the desired tension is applied to the entire bone structure being secured with the flexible sutures. Once the desired tension is achieved, the device preferably provides a mechanism to apply a uniform twist to the flexible suture to lock the flexible suture in place and maintain the tension previously achieved. The device may automatically cut the flexible suture, or the flexible suture may be cut by the surgeon once the twisting action has been performed.

摘要翻译： 可以使用外科器械将张力施加到柔性缝合线上以闭合并固定破碎或切割的骨（例如在胸骨切开后的胸骨）。 该装置优选地将可调节的张力施加到柔性缝合线上，以将骨头固定在一起。 多个器械可以一起使用以确保用柔性缝合线固定的整个骨结构施加期望的张力。 一旦实现所需的张力，该装置优选地提供一种机制，以将均匀的扭转施加到柔性缝合线以将柔性缝合线锁定在适当位置并保持先前​​实现的张力。 该装置可以自动切割柔性缝合线，或者一旦执行了扭转动作，则可以由外科医生切割柔性缝合线。

公开(公告)号：US08932287B2

公开(公告)日：2015-01-13

申请号：US13070215

申请日：2011-03-23

申请人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

发明人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

IPC分类号： A61B18/14 ,  A61B5/06 ,  A61B18/18 ,  A61B18/20 ,  A61B18/00 ,  A61B18/02

CPC分类号： A61B18/1492 ,  A61B5/06 ,  A61B5/065 ,  A61B5/4875 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/025

摘要： A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

摘要翻译： 可以在身体器官（例如心脏）的空腔中定位的装置可以区分流体（例如血液）和非流体组织（例如，心脏壁），以提供信息或指示位置和/或 器件在腔中的取向。 歧视可以基于流量或其他一些特性，例如电容率或力。 该装置可以基于信息或映射来选择性地烧蚀非流体组织的部分。 该装置可以检测指示消融是否成功的特征（例如，电位）。 该装置可以包括多个换能器，以未膨胀的构造血管内引导并且以扩张构型定位在非流体组织附近。 膨胀机构可以包括螺旋构件或可膨胀构件。

公开(公告)号：US20110172658A1

公开(公告)日：2011-07-14

申请号：US13070215

申请日：2011-03-23

申请人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

发明人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B5/06 ,  A61B5/065 ,  A61B5/4875 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/025

摘要： A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

摘要翻译： 可以在身体器官（例如心脏）的空腔中定位的装置可以区分流体（例如血液）和非流体组织（例如，心脏壁），以提供信息或指示位置和/或 器件在腔中的取向。 歧视可以基于流量或其他一些特性，例如电容率或力。 该装置可以基于信息或映射来选择性地烧蚀非流体组织的部分。 该装置可以检测指示消融是否成功的特征（例如，电位）。 该装置可以包括多个换能器，以未膨胀的构造血管内引导并且以扩张构型定位在非流体组织附近。 膨胀机构可以包括螺旋构件或可膨胀构件。

公开(公告)号：US08906011B2

公开(公告)日：2014-12-09

申请号：US11941819

申请日：2007-11-16

申请人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

发明人： Daniel Gelbart ,  Doug Goertzen ,  Fernando Lopes

IPC分类号： A61B18/14 ,  A61B5/06 ,  A61B18/18 ,  A61B18/02 ,  A61B18/20 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B5/06 ,  A61B5/065 ,  A61B5/4875 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/025

摘要： A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

摘要翻译： 可以在身体器官（例如心脏）的空腔中定位的装置可以区分流体（例如血液）和非流体组织（例如，心脏壁），以提供信息或指示位置和/或 器件在腔中的取向。 歧视可以基于流量或其他一些特性，例如电容率或力。 该装置可以基于信息或映射来选择性地烧蚀非流体组织的部分。 该装置可以检测指示消融是否成功的特征（例如，电位）。 该装置可以包括多个换能器，以未膨胀的构造血管内引导并且以扩张构型定位在非流体组织附近。 膨胀机构可以包括螺旋构件或可膨胀构件。

公开(公告)号：US10980737B1

公开(公告)日：2021-04-20

申请号：US15452712

申请日：2017-03-07

申请人： Samuel Victor Lichtenstein ,  Daniel Gelbart

发明人： Samuel Victor Lichtenstein ,  Daniel Gelbart

IPC分类号： A61K9/00 ,  A61M31/00 ,  A61M16/14 ,  A61B18/14 ,  A61K45/06 ,  A61B18/00

摘要： The invention can selectively heat a diseased area in the lung while minimizing heating to the healthy area and surrounding tissue. This is done by exposing the lung to an electromagnetic field causing dielectric or eddy current heating. The invention is particularly useful for treating emphysema as the diseased areas have reduced blood flow. The diseased area will heat up rapidly while the healthy tissue will be cooled by the blood flow. This is particularly effective for treating emphysema because of the low mass of the lungs and the high blood flow. To avoid heating of surrounding organs the direction of the electromagnetic energy is switched in a way it always passes through lungs but only intermittently passes through adjacent organs. If heat activated drugs are present in the lungs, they are selectively released in the heated tissue.