公开(公告)号：US20070275442A1

公开(公告)日：2007-11-29

申请号：US10574967

申请日：2004-10-07

申请人： Jonathan Brown ,  Steven Homans ,  Michael Chaykovsky ,  Jenny Murray

发明人： Jonathan Brown ,  Steven Homans ,  Michael Chaykovsky ,  Jenny Murray

IPC分类号： G01N33/53 ,  C07C211/01 ,  G01N24/08 ,  C12P21/06

CPC分类号： C07B59/001 ,  C07B59/008 ,  C07B2200/05

摘要： Protein structural determination using NMR techniques is improved through use of proteins in which one or more amino acids in the peptidic sequence are isotopically enriched in the sidechain with 2H and are isotopically enriched on the backbone with 13C, 15N, 2H or any combination thereof. This invention provides amino acids isotopically enriched as above, which can be used to synthesize isotopically labeled proteins and peptides for protein structural determinations by NMR, and methods for their synthesis. Other embodiments of the invention include peptidic molecules, media for peptidic molecule expression, methods of making isotopically labeled peptidic molecules and methods of determining structural information of a peptidic molecule.

摘要翻译： 通过使用蛋白质来改进使用NMR技术的蛋白质结构测定，其中肽序列中的一个或多个氨基酸与侧链同时富含2H，并且在13C，15N，2H或其任何组合的骨架上同时富集。 本发明提供如上同位素富集的氨基酸，其可用于通过NMR合成用于蛋白质结构测定的同位素标记的蛋白质和肽及其合成方法。 本发明的其它实施方案包括肽分子，用于肽分子表达的培养基，制备同位素标记的肽分子的方法和确定肽分子的结构信息的方法。

公开(公告)号：US20060154323A1

公开(公告)日：2006-07-13

申请号：US10517380

申请日：2003-06-10

申请人： Jonathan Brown ,  Steven Homans ,  Minn-Chang Cheng ,  Michael Chaykovsky ,  Jenny Murray

发明人： Jonathan Brown ,  Steven Homans ,  Minn-Chang Cheng ,  Michael Chaykovsky ,  Jenny Murray

IPC分类号： C12Q1/37 ,  C12Q1/04 ,  G01N33/00 ,  C07C229/02

CPC分类号： C07B59/008 ,  C07B59/001 ,  C07B2200/05 ,  C07C229/08 ,  C07K14/4702 ,  C07K2299/00 ,  G01N33/6803

摘要： This invention provides an NMR method for obtaining both entropic and enthalpic data on proteins and protein/ligand complexes which can be used to obtain accurate structural and dynamic data of proteins and protein complexes having a wide range of molecular weights. An embodiment of the invention provides proteins which contain at least one bond vector whose dynamics are to be measured and which is surrounded by NMR inactive nuclei, and amino acids for synthesis of the proteins via chemical means or biological expression. The NMR methods using specifically labeled proteins for analysis result in maximization of the sensitivity and resolution of the NMR experiments, and minimization of the loss of signal due to diffusion.

摘要翻译： 本发明提供了一种用于获得蛋白质和蛋白质/配体配合物的熵和焓数据的NMR方法，其可用于获得具有宽范围分子量的蛋白质和蛋白质复合物的精确结构和动态数据。 本发明的一个实施方案提供了蛋白质，其含有至少一种键合载体，其动力学将被测量并被NMR无活性核包围，以及用于通过化学方法或生物表达合成蛋白质的氨基酸。 使用特异性标记的蛋白质进行分析的NMR方法导致NMR实验的灵敏度和分辨率的最大化，以及由于扩散引起的信号损失的最小化。

公开(公告)号：US20200234376A1

公开(公告)日：2020-07-23

申请号：US16253734

申请日：2019-01-22

申请人： Erik R. Lord ,  Thomas F. Morgan ,  Brian L. Fresher ,  Armand J. Minutillo ,  Cynthia D. Finley ,  Marie C. Norcia ,  Jonathan Brown ,  Willis D. Schmidt, JR.

发明人： Erik R. Lord ,  Thomas F. Morgan ,  Brian L. Fresher ,  Armand J. Minutillo ,  Cynthia D. Finley ,  Marie C. Norcia ,  Jonathan Brown ,  Willis D. Schmidt, JR.

IPC分类号： G06Q40/08 ,  G06Q10/06

摘要： A system may receive a first resource allocation request (associated with a first company) from a first entity. The system may determine that the first request is not associated with a risk relationship and arrange for it to be processed via a claim servicing entity. Information about the first request may then be routed to a request handler device for processing and a communication with a first graphical indication may be generated. The system may also receive a second resource allocation request (associated with the first company) from a second entity and determine that it is to be processed via a risk. The system may then route information about the second request to a request handler device for processing and generate a communication with a second graphical indication. Note that the request handler device may be the same device that received the information about the first request.

公开(公告)号：US20050213306A1

公开(公告)日：2005-09-29

申请号：US11089673

申请日：2005-03-25

申请人： David Vos ,  Douglas Bendzel ,  David Bittler ,  Jonathan Brown

发明人： David Vos ,  Douglas Bendzel ,  David Bittler ,  Jonathan Brown

IPC分类号： H05K7/20

CPC分类号： H05K7/20609

摘要： A method and apparatus for housing electronic components, such as commercial-off-the-shelf (COTS) electronics, in a chamber, or cocoon, so as to protect the components from environmental conditions outside the chamber. In one embodiment, a heat exchanger used to transfer heat between the chamber and its exterior may be incorporated into a wall of the chamber, e.g., located at a sidewall of the chamber. The heat exchanger may use a liquid to transfer heat between the heat exchanger and air in the chamber.

摘要翻译： 一种用于将诸如商业现货（COTS）电子器件的电子部件放置在腔室或茧中的电子部件的方法和装置，以便保护部件免受室外的环境条件的影响。 在一个实施例中，用于在室和其外部之间传递热量的热交换器可以结合到室的壁中，例如位于室的侧壁处。 热交换器可以使用液体来在热交换器和腔室中的空气之间传递热量。

公开(公告)号：US06659177B2

公开(公告)日：2003-12-09

申请号：US09960570

申请日：2001-09-20

申请人： Victor M. Bolze ,  Jonathan Brown ,  Andrew Kurkjian

发明人： Victor M. Bolze ,  Jonathan Brown ,  Andrew Kurkjian

IPC分类号： E21B4908

CPC分类号： E21B49/082 ,  E21B49/081

摘要： A sample module for use in a downhole tool includes a sample chamber for receiving and storing pressurized fluid. A piston is slidably disposed in the chamber to define a sample cavity and a buffer cavity, and the cavities have variable volumes determined by movement of the piston. A first flowline is provided for communicating fluid obtained from a subsurface formation through the sample module. A second flowline connects the first flowline to the sample cavity, and a third flowline connects the first flowline to the buffer cavity for communicating buffer fluid out of the buffer cavity. A first valve capable of moving between a closed position and an open position is disposed in the second flowline for communicating flow of fluid from the first flowline to the sample cavity. When the first valve is in the open position, the sample cavity and the buffer cavity are in fluid communication with the first flowline and therefore have equivalent pressures.

公开(公告)号：US20070058335A1

公开(公告)日：2007-03-15

申请号：US11491296

申请日：2006-07-22

申请人： Jonathan Brown ,  Gary Deaton ,  Ryan Riegle

发明人： Jonathan Brown ,  Gary Deaton ,  Ryan Riegle

IPC分类号： G06F1/16

CPC分类号： G11B33/08 ,  G06F1/187

摘要： A rugged hard disk drive storage assembly is disclosed. The rugged hard disk drive storage assembly includes an enclosure capable of containing multiple hard disk drives. The enclosure also contains multiple shock and vibration absorbers that are configured to elastically support all the hard disk drives contained within the enclosure. The multiple shock absorbers protect the delicate electronic hard disk drives and their sensitive information from shock and vibration damage, even when the enclosure has been removed from the drive container, and is being carried away by personal in a harsh combat environment. In addition, the enclosure is hermetically sealed such that the hard disk drives are isolated from external environment.

摘要翻译： 公开了一种坚固的硬盘驱动器存储组件。 坚固的硬盘驱动器存储组件包括能够容纳多个硬盘驱动器的机箱。 外壳还包含多个冲击和振动吸收器，其配置为弹性地支撑包含在外壳内的所有硬盘驱动器。 多个减震器可保护精密的电子硬盘驱动器及其敏感信息免受冲击和振动损坏，即使外壳已从驱动器容器中取出，并在恶劣的作战环境中被个人携带。 此外，外壳是密封的，使得硬盘驱动器与外部环境隔离。

公开(公告)号：US20060179463A1

公开(公告)日：2006-08-10

申请号：US11052393

申请日：2005-02-07

申请人： Alpin Chisholm ,  Phillip Gregory ,  Jonathan Brown ,  Paul Vanslette

发明人： Alpin Chisholm ,  Phillip Gregory ,  Jonathan Brown ,  Paul Vanslette

IPC分类号： H04N7/173

CPC分类号： G08B13/1968 ,  G08B13/19656 ,  G08B13/19667 ,  G08B13/19673 ,  G08B13/19682 ,  H04N7/181

摘要： At a remote location, audio-visual data is received and processed to produce processed audio-visual data. The processed audio-visual data is communicated to a central location using a programmable logic controller communication protocol.

摘要翻译： 在远程位置，接收和处理视听数据以产生经处理的视听数据。 处理的视听数据使用可编程逻辑控制器通信协议传送到中心位置。

公开(公告)号：US06467544B1

公开(公告)日：2002-10-22

申请号：US09712373

申请日：2000-11-14

申请人： Jonathan Brown ,  Victor Bolze

发明人： Jonathan Brown ,  Victor Bolze

IPC分类号： E21B4908

CPC分类号： E21B49/082

摘要： A sample module for use in a downhole tool includes a sample chamber for receiving and storing pressurized fluid. A piston is slidably disposed in the chamber to define a sample cavity and a buffer cavity, and the cavities have variable volumes determined by movement of the piston. A first flowline is provided for communicating fluid obtained from a subsurface formation through the sample module. A second flowline connects the first flowline to the sample cavity, and a third flowline connects the sample cavity to one of the first flowline and an outlet port. A first valve is disposed in the second flowline for controlling the flow of fluid from the first flowline to the sample cavity, and a second valve is disposed in the third flowline for controlling the flow of fluid out of the sample cavity, whereby any fluid preloaded in the sample cavity may be flushed therefrom using the formation fluid in the first flowline and the first and second valves.

摘要翻译： 用于井下工具的样品模块包括用于接收和储存加压流体的样品室。 活塞可滑动地设置在腔室中以限定样品腔和缓冲腔，并且空腔具有由活塞运动确定的可变容积。 第一流线被提供用于将从地下地层获得的流体通过样品模块。 第二流线将第一流线连接到样品腔，并且第三流线将样品腔连接到第一流线和出口之一。 第一阀设置在第二流线中，用于控制从第一流线到样品腔的流体流动，第二阀设置在第三流线中，用于控制流体流出样品腔，由此预先加载任何流体 可以使用第一流线中的地层流体和第一和第二阀从样品腔中冲洗样品腔。

公开(公告)号：US09926738B1

公开(公告)日：2018-03-27

申请号：US15626957

申请日：2017-06-19

申请人： Jonathan Brown ,  Amber Brown

发明人： Jonathan Brown ,  Amber Brown

IPC分类号： E06B3/68 ,  E06B9/04 ,  E06B3/46 ,  E06B9/00

CPC分类号： E06B9/04 ,  E06B2009/002

摘要： A safety gate for enclosing a passageway includes first and second gate members situated in an overlapping arrangement for slidable movement horizontally so that a width defined collectively by the gate members is selectable. The second gate member is essentially received by the first gate member. Each gate member includes an upstanding proximal end panel and spaced apart upper and lower panels extending away from the respective proximal end panel, the upper and lower panels having terminal ends, respectively, that together define a void therebetween. Each gate member includes an upper rail member extending horizontally along an upper edge of the first gate member that is perpendicular to respective upper panels. The first and the second rail members are situated one atop the other and share a singular vertical axis extending through them.

公开(公告)号：US20130252331A1

公开(公告)日：2013-09-26

申请号：US13697963

申请日：2011-05-16

申请人： James Elliott Bradner ,  Jonathan Brown ,  Jorge Plutzky

发明人： James Elliott Bradner ,  Jonathan Brown ,  Jorge Plutzky

IPC分类号： C07D495/14 ,  A61K31/7088

CPC分类号： C07D495/14 ,  A61K31/00 ,  A61K31/551 ,  A61K31/5517 ,  A61K31/69 ,  A61K31/7088

摘要： The invention provides compositions comprising an effective amount of an agent that inhibits a BET protein (e.g., Brd2, Brd3, Brd4), and methods of using such compositions for treating or preventing metabolic syndrome, obesity, type II diabetes, insulin resistance, and related disorders characterized by undesirable alterations in metabolism or fat accumulation.

摘要翻译： 本发明提供了包含有效量的抑制BET蛋白质的试剂（例如Brd2，Brd3，Brd4）的组合物，以及使用这些组合物治疗或预防代谢综合征，肥胖症，II型糖尿病，胰岛素抵抗和相关 特征在于代谢或脂肪积累的不良变化的疾病。