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    Permeant delivery system and methods for use thereof
    1.
    发明申请
    Permeant delivery system and methods for use thereof 审中-公开
    渗透输送系统及其使用方法

    公开(公告)号：US20070031495A1

    公开(公告)日：2007-02-08

    申请号：US11455899

    申请日：2006-06-19

    Applicant: Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

    Inventor： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

    IPC: A61K9/24

    CPC classification number: A61K9/7053 ,  A61K9/0009

    Abstract: Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

    Abstract translation: 公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。 所述装置包括递送贮存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中，当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触 与至少一个形成的途径。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。

    Transdermal drug delivery patch system, method of making same and method of using same
    2.
    发明授权
    Transdermal drug delivery patch system, method of making same and method of using same 有权
    透皮给药贴剂系统，制备方法及使用方法

    公开(公告)号：US07392080B2

    公开(公告)日：2008-06-24

    申请号：US10384779

    申请日：2003-03-11

    Applicant: Jonathan Eppstein ,  Stuart McRae ,  Alan Smith

    Inventor： Jonathan Eppstein ,  Stuart McRae ,  Alan Smith

    IPC: A61N1/30

    CPC classification number: A61M37/0015 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2210/04 ,  A61M2230/20 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/325 ,  A61N1/326 ,  A61N1/327

    Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for attaching the porator array to a tissue membrane; and iii) an extension tab laterally and removably attached to the bottom surface, the extension tab including an adhesive applied on the bottom thereof, thereby allowing the extension tab to remain on the tissue membrane upon removal of the porator array; and iv) a release liner removably attached to the bottom surface; and c) a reservoir patch attached to the extension tab, the reservoir patch being applied to the microporated area of the tissue membrane after poration. The invention also provides for methods of making and methods of using the same.

    Abstract translation: 本发明提供用于形成药物递送贴片系统的透皮药物递送装置，包括：a）致动器，其包括：i）限定所述致动器的顶部的外体，所述外体包含空腔; ii）控制器板，包括驱动电子器件和电池，所述控制器板定位在所述腔内; 以及iii）用于接收搬运器阵列的接口连接端口，所述接口连接端口包含阳极和阴极; b）所述搬运器阵列包括：i）顶表面，具有附着到所述顶表面的可移除粘合剂，所述顶表面包含两个同心的电接触环，用于在去除所述粘合剂层时接触阳极和阴极处的界面连接端口 ; ii）包含组织界面膜的底部表面，所述组织界面膜还包括具有包含在所述基底上或内部的至少一个穿孔器的基底，所述底表面还包括用于将所述穿孔器阵列附接到组织膜的粘合剂层; 以及iii）横向和可移除地附接到底表面的延伸片，所述延伸片包括施加在其底部上的粘合剂，从而允许延伸片在去除所述穿孔器阵列时保留在所述组织膜上; 以及iv）可移除地附接到所述底表面的释放衬垫; 以及c）附着到所述延伸片的储存器贴片，所述储存器贴片在穿孔之后被施加到所述组织膜的微孔区域。 本发明还提供了制备方法及其使用方法。

    Transdermal integrated actuator device, methods of making and using same
    7.
    发明授权
    Transdermal integrated actuator device, methods of making and using same 有权
    透皮一体化执行机构，制作及使用方法

    公开(公告)号：US09486616B2

    公开(公告)日：2016-11-08

    申请号：US14197995

    申请日：2014-03-05

    Applicant: Jonathan Eppstein ,  Stuart McRae

    Inventor： Jonathan Eppstein ,  Stuart McRae

    IPC: A61M37/00 ,  A61N1/04 ,  A61N1/32

    CPC classification number: A61M37/0015 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2210/04 ,  A61M2230/20 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/325 ,  A61N1/326 ,  A61N1/327

    Abstract: Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

    Abstract translation: 提供用于监测从患者提取的分析物并将渗透物组合物输送给患者的方法。 该方法包括以下步骤：a）使点心装置与患者的组织膜接触，该装置装置包括至少一个穿孔器阵列; b）使用所述定位装置中的所述至少一个穿孔器阵列致动所述组织膜的穿孔; c）通过所述至少一个转子阵列从所述打开的组织膜提取分析物; d）分析分析物以确定组织膜内分析物的浓度; 以及e）通过所述至少一个导向器阵列将渗透物组合物输送到所述组织膜。

    Transdermal Integrated Actuator Device, Methods of Making and Using Same
    8.
    发明申请
    Transdermal Integrated Actuator Device, Methods of Making and Using Same 有权
    透皮整合致动器装置，制作和使用方法

    公开(公告)号：US20140228736A1

    公开(公告)日：2014-08-14

    申请号：US14197995

    申请日：2014-03-05

    Applicant: Jonathan Eppstein ,  Stuart McRae

    Inventor： Jonathan Eppstein ,  Stuart McRae

    IPC: A61M37/00 ,  A61N1/32 ,  A61N1/04

    CPC classification number: A61M37/0015 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2210/04 ,  A61M2230/20 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/325 ,  A61N1/326 ,  A61N1/327

    Abstract: Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

    Abstract translation: 提供用于监测从患者提取的分析物并将渗透物组合物输送给患者的方法。 该方法包括以下步骤：a）将定位装置接触患者的组织膜，该装置装置包括至少一个穿孔器阵列; b）使用所述定位装置中的所述至少一个穿孔器阵列致动所述组织膜的穿孔; c）通过所述至少一个转子阵列从所述打开的组织膜提取分析物; d）分析分析物以确定组织膜内分析物的浓度; 以及e）通过所述至少一个导向器阵列将渗透物组合物输送到所述组织膜。

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