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公开(公告)号：US08637018B2
公开(公告)日：2014-01-28
申请号：US13315358
申请日：2011-12-09
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
摘要翻译： 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20120100137A1
公开(公告)日：2012-04-26
申请号：US13315358
申请日：2011-12-09
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
摘要翻译： 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08133978B2
公开(公告)日：2012-03-13
申请号：US11752707
申请日：2007-05-23
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
摘要翻译： 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US20100221260A1
公开(公告)日：2010-09-02
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US09193784B2
公开(公告)日：2015-11-24
申请号：US13491810
申请日：2012-06-08
申请人： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： C07K16/18 , A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要： Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译： 结合人和淀粉样蛋白肽的抗体，以所述抗体为特征的疾病或病症的特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物的方法，包含所述抗体的药物组合物和制备方法。
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公开(公告)号：US08227576B2
公开(公告)日：2012-07-24
申请号：US12294438
申请日：2007-03-27
申请人： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要： Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译： 结合人和淀粉样蛋白肽的抗体，以所述抗体为特征的疾病或病症的特征在于淀粉样蛋白水平升高或淀粉样沉积的方法，包含所述抗体的药物组合物和制造方法。
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公开(公告)号：US20110142824A1
公开(公告)日：2011-06-16
申请号：US12294438
申请日：2007-03-27
申请人： Stephan Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Phillpott , Peter Ernest Soden
发明人： Stephan Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Phillpott , Peter Ernest Soden
IPC分类号： A61K39/395 , C07K16/18 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要： Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译： 结合人和淀粉样蛋白肽的抗体，以所述抗体为特征的疾病或病症的特征在于淀粉样蛋白水平升高或淀粉样沉积的方法，包含所述抗体的药物组合物和制造方法。
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公开(公告)号：US20110064740A1
公开(公告)日：2011-03-17
申请号：US12679917
申请日：2008-09-23
申请人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： A61K39/395 , C07K16/00 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要： The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译： 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US20110014182A1
公开(公告)日：2011-01-20
申请号：US12746837
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61P25/28 , A61K38/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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